Helicid
- CAS No.
- 80154-34-3
- Chemical Name:
- Helicid
- Synonyms
- HELICID;Hiliedum;HELICIDE;HELICIDUM;HILICIDUM;Gynostemma;2-formylphenyl;Tofu glycoside;Helicid/Helicide;Helicid USP/EP/BP
- CBNumber:
- CB0178132
- Molecular Formula:
- C13H16O7
- Molecular Weight:
- 284.26
- MDL Number:
- MFCD00210992
- MOL File:
- 80154-34-3.mol
| Melting point | 199-200°C |
|---|---|
| alpha | -27 º (c=3.2, MeOH) |
| Boiling point | 559.9±50.0 °C(Predicted) |
| Density | 1.510±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMF: 1 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml |
| form | Powder |
| pka | 12.72±0.70(Predicted) |
| color | White to Off-white |
| Water Solubility | Soluble in hot water. Slightly soluble in water, ethanol or carbinol. Insoluble in aether or chloroform. |
| InChIKey | OLZAGZCCJJBKNZ-VLJOUNFMSA-N |
| CAS DataBase Reference | 80154-34-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P261-P271 | |||||||||
| HS Code | 29389090 | |||||||||
| NFPA 704 |
|
Helicid price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL82556 | Helicid phyproof? Reference Substance | 80154-34-3 | 25mg | $286 | 2024-03-01 | Buy |
| TCI Chemical | F0542 | 4-Formylphenyl beta-D-Allopyranoside >98.0%(HPLC) | 80154-34-3 | 5g | $126 | 2024-03-01 | Buy |
| Alfa Aesar | J66102 | 4-Formylphenyl beta-D-allopyranoside, 98% | 80154-34-3 | 5g | $56.65 | 2024-03-01 | Buy |
| Alfa Aesar | J66102 | 4-Formylphenyl beta-D-allopyranoside, 98% | 80154-34-3 | 1g | $25.9 | 2021-12-16 | Buy |
| Usbiological | 300409 | Helicide | 80154-34-3 | 20mg | $320 | 2021-12-16 | Buy |
Helicid Chemical Properties,Uses,Production
Brief description
Helicid is the active ingredient isolated from the fruit of proteaceae plant Helicia nilagirica, with its chemical structure being similar to gastrodin (hydroxymethyl benzene - O-β-D-glucopyranoside). Pharmacological and clinical studies have shown that helicid has similar effects on the central nervous system with gastrodin, but its sedative, euthanasia and analgesic effect is stronger than gastrodin. The efficacy on the treatment of neurosis efficacy is definite without rebound insomnia and drug dependence. Therefore, it has excellent clinical value. Its fruit tablets have been used in clinical.
Extraction and Separation
Figure 1 the process of purification of helicid from the fruit of proteaceae plant Helicia nilagirica
Determination of content
HPLC method
(1) Chromatographic conditions
Column: YWCT-C18 (25cm × 2.6mm, 10μm) high pressure grouting method. Flowing phase: methanol-water (20:80); flow rate: 0.7 ml / min; column temperature: room temperature; UV detection wavelength: 270 nm; paper speed: 2.5 mm / min.
(2) Reference solution preparation
Precisely weigh control reference substance of helicid; prepare 1 mg/mL solution using 20% methanol. Precise weigh Bergenin; dissolve in 20% methanol; apply ultrasonic solubilization, dub bergenin into about 2mg / ml internal standard solution.
(3) Preparation of sample solution
Accurately weighed dried helicid powder of about 1g, and put it into 25ml volumetric flask; add 20 mL methanol for soak of 0.5 h; ultrasonic extraction 80min, cool, set volume into 25 mL with methanol; filter and filtrate will become the sample solution.
(4) Determination
Take helicid reference solution in 5ml volumetric flask, add bergenin internal standard solution of 1.5ml; diluted with 20% methanol to the mark, mix; take 5 mL sample solution, volatilize; add 1. 5mL the internal standard solution; dilute with 20% methanol to the mark, mix well. Take 5μl of both reference substance and sample solution, inject, determine according to the chromatographic conditions; calculate the content with peak area ratio.
(5) Measurement results
Use the above internal standard method to measure the content of helicid in Samples I and II, and the results were 0.963% and 0.928%.
Its chemical structure is similar to Gastrodia; have a strong analgesic, sedation and euthanasia effect. It is used for the treatment of neurasthenia, neurasthenic syndrome, functional disorders, vascular headache and trigeminal neuralgia. It has remarkable effect on neurasthenic headache, dizziness and sleep disorders.
Chemical Properties
It appears as white needle-like crystals, mp.190 °C ~ 193 °C, [α] D20-100 ° ~ -108 ° (water).
Uses
It is used in the treatment of ischemic cardiovascular and cerebrovascular diseases. Also used in Chinese medicine in the treatment of headache and insomnia.
Definition
ChEBI: Helicid is a glycoside.
Helicid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 | Sara@xmwonderfulbio.com | China | 305 | 58 |
| Shanghai Affida new material science and technology center | +undefined15081010295 | 2691956269@qq.com | China | 359 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
View Lastest Price from Helicid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-28 | Helicid; Helicia nilagirica extract
80154-34-3
|
US $0.00 / KG | 1KG | ≥98% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2024-03-13 | Helicide
80154-34-3
|
US $0.00-0.00 / KG | 1KG | 99 | 8000 | Shanghai Affida new material science and technology center | |
 |
2024-01-18 | Helicid
80154-34-3
|
US $88.00 / kg | 1kg | 99.98% | 8000 | Xiamen Wonderful Bio Technology Co., Ltd. |
-
- Helicid; Helicia nilagirica extract
80154-34-3
- US $0.00 / KG
- ≥98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Helicide
80154-34-3
- US $0.00-0.00 / KG
- 99
- Shanghai Affida new material science and technology center
-
- Helicid
80154-34-3
- US $88.00 / kg
- 99.98%
- Xiamen Wonderful Bio Technology Co., Ltd.