ChemicalBook >> CAS DataBase List >>7,8-Dihydroxycoumarin

7,8-Dihydroxycoumarin

CAS No.
486-35-1
Chemical Name:
7,8-Dihydroxycoumarin
Synonyms
Daphetin;DAPHNETIN;Daphnetol;Daphenetin;AKOS 213-37;DAPHNETIN(P);Daphnetin>Daphnetin, 97%+;Daphnetin,HPLC≥98%;Daphnetin, ≥ 90.0%
CBNumber:
CB0410069
Molecular Formula:
C9H6O4
Molecular Weight:
178.14
MDL Number:
MFCD00016977
MOL File:
486-35-1.mol
MSDS File:
SDS
Last updated:2024-04-22 15:07:34

7,8-Dihydroxycoumarin Properties

Melting point 265-268°C (dec.)
Boiling point 270.35°C (rough estimate)
Density 1.3431 (rough estimate)
refractive index 1.4500 (estimate)
storage temp. room temp
solubility soluble in Methanol
form solid
pka 7.61±0.20(Predicted)
color White to Light yellow to Light red
Merck 14,2817
InChIKey ATEFPOUAMCWAQS-UHFFFAOYSA-N
LogP 0.884 (est)
CAS DataBase Reference 486-35-1(CAS DataBase Reference)
FDA UNII XC84571RD2

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi
Risk Statements  25-36/37/38-20/21
Safety Statements  22-24/25-36-26-36/37/39
WGK Germany  2
RTECS  GN6382600
HS Code  29322090
NFPA 704
0
2 0

7,8-Dihydroxycoumarin price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D5564 7,8-Dihydroxycoumarin ≥97%, powder 486-35-1 5mg $111 2024-03-01 Buy
Sigma-Aldrich D5564 7,8-Dihydroxycoumarin ≥97%, powder 486-35-1 25mg $428 2024-03-01 Buy
TCI Chemical D4001 Daphnetin >90.0%(HPLC) 486-35-1 1g $170 2024-03-01 Buy
TCI Chemical D4001 Daphnetin >90.0%(HPLC) 486-35-1 5g $512 2024-03-01 Buy
Cayman Chemical 20826 Daphnetin ≥90% 486-35-1 10mg $57 2024-03-01 Buy
Product number Packaging Price Buy
D5564 5mg $111 Buy
D5564 25mg $428 Buy
D4001 1g $170 Buy
D4001 5g $512 Buy
20826 10mg $57 Buy

7,8-Dihydroxycoumarin Chemical Properties,Uses,Production

Description

Daphnetin, mainly extracted from Yu Ruixiang Changbai Daphne (Daphne Korean Nakai), Daphne giraldii Nitsche bark, and root bark, is the main efficacy component of the plants D.tangutica Maxim and D.retttsa Hemsl. Changbai daphnes has the pharmacological effects of warming the spleen and stomach, relaxing the muscles and joints, and promoting circulation. In TCM, it’s commonly used as medicines for treatment of injuries. Because Changbai daphne is a pungent and warm natured herbal medicine, it was used to warm the spleen and stomach by dispelling cold.

Physical properties

Appearance: white or off-white powder, odorless, and tasteless; Solubility: slightly soluble in methanol (equilibrium solubility of 485.4? μg/mL), slightly soluble in ethanol (equilibrium solubility of 230.06?μg/mL), and insoluble in water (equilibrium solubility of 176.7?μg/mL) ; Melting point: 262–264?°C.

History

Changbai daphne, a Chinese traditional medicine in clinic, is mainly used for treatment of coronary heart disease, rheumatoid arthritis, thromboangiitis obliterans, etc. Changbai daphne belongs to the first-class protective plants in Jilin province in China, and the rarity restricted the drug development. Scientists tried to find the effective components of Changbai daphne. In 1977, scientists of phytochemistry research group in the Traditional Chinese Medicine research laboratory from Jilin institute of Chinese medicine first successfully isolated the crystalline monomer?– daphnetin?– from the plant. Pharmacological results show that the pharmacological activities of this crystal are equal to Changbai daphne, which suggested the crystal is the main active ingredient . Through the condensation reaction experiment using equimolecular pyrogallic acid, malic acid, and twice the amount of sulfuric acid, under heating reaction, scientists successfully got pale yellow needle daphnetin crystals. From then on artificially synthesized daphnetin has been successfully implemented . A large-scale industrial production can be acquired. The followup researches on the metabolism and pharmacological activity of daphnetin were carried out. In 2009, the State Food and Drug Administration of China approved daphnetin capsule to be used in the clinical.

Uses

Daphnetin is a natural coumarin derivative providing anti-inflammatory and protective properties to those suffering from lung injury.

Indications

This product is contained in national standards for chemical drugs, mainly used in Buerger’s disease, occlusive vascular disease, and coronary heart disease.

Definition

ChEBI: 7,8-dihydroxycoumarin is a hydroxycoumarin.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

7,8-Dihydroxycoumarinan is an inhibitor of protein kinases. It is an active lactone present in plants such as Daphne Korean Nakai, and Thymelaeaceae Daphne. It serves as as analgesic, antiviral and antibacterial agent. 7,8-Dihydroxycoumarinan is found to induce tumor apoptosis via a number of signalling pathways. Thus, it is believed to exhibit antitumor effects. 7,8-Dihydroxycoumarinan might also be useful in treating lung carcinoma. It is also known to be used in treating coagulation disorders and rheumatoid arthritis. 7,8-Dihydroxycoumarinan is known to induce neurite growth and lengthen neuronal survival. It helps in clearing substances inducing necrosis, maintains water-electrolytes balance and energy metabolism. 7,8-Dihydroxycoumarinan is involved in the generation of neurotrophic factor and helps in restoring neuron function.

Pharmacology

Daphnetin pharmacological effect mainly includes: 1. Improvement of the cardiovascular system function; 2. Effects on the central nervous system. Daphnetin also acts on the NF-k B and NFAT signal pathway and results in immune inhibition; it is also used for the treatment of malaria parasite and Pneumocystis carinii infection by chelating to Fe2 + or by acting on ribonucleotide reductase; daphnetin shows bacteriostatic effects on gold grapes, Escherichia coli, Shigella’s blessing, and Pseudomonas aeruginosa by inhibiting succinic acid oxidase in mitochondria in bacteria; daphnetin reduces the incidences of diarrhea in model mice by inhibiting mice gastrointestinal propulsive movement and has a stronger toxic effect on several important aphids .
Plasma protein binding of Daphetin is low. The urinary excretion is higher. The distribution volume is relatively larger. Both of metabolism and excretion are rapid. Drug elimination is mainly through the kidney with a half-life of only 15 min. The tissue distributions after intravenous injection and oral administration are equal. Daphnetin may distribute in the brain through the blood-brain barrier. The metabolites have poor stability and low oral bioavailability. People have studied the metabolic pathways and metabolic product. Daphnetin may be the substrates of MRP2 and BCRP transporters, and thus intestinal absorption is affected; in the plasma of rats, the main metabolite are 7-O and 8-O glucoside substitution products which are mediated by UT1A6 and UT1A9. The anti-inflammatory activity of the metabolites is dependent on daphnetin-7-methyl ether.

Clinical Use

It has been verified by a large number of clinical cases that oral daphnetin capsule can significantly improve thromboangiitis obliterans; oral daphnetin has a better curative effect than intramuscular injection of Changbai daphne in patients with angina pectoris due to coronary heart disease. Daphnetin shows an obvious analgesic sedative effect on surgical and nonsurgical pain-relieved patients after intravenous drip or injection of daphnetin; oral daphnetin capsule shows significant therapeutic effects on rheumatoid arthritis.
There are no reports about serious adverse reactions. Two cases of whole-body red itch were reported. It sometimes has mild gastrointestinal reaction when continuously used.

storage

Room temperature

Purification Methods

Crystallise it from aqueous EtOH. It can be sublimed. [Beilstein 18/3 V 202.].

471-25-0
87-66-1
486-35-1
Synthesis of 7,8-Dihydroxycoumarin from Propiolic Acid and Pyrogallol
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View Lastest Price from 7,8-Dihydroxycoumarin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Daphnetin pictures 2024-04-22 Daphnetin
486-35-1
US $10.00 / kg 1kg 99.912% 10ton Ouhuang Engineering Materials (Hubei) Co., Ltd
7,8-Dihydroxycoumarin pictures 2023-07-01 7,8-Dihydroxycoumarin
486-35-1
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
Daphnetin pictures 2023-02-24 Daphnetin
486-35-1
US $0.00 / mg 20mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
  • Daphnetin pictures
  • Daphnetin
    486-35-1
  • US $10.00 / kg
  • 99.912%
  • Ouhuang Engineering Materials (Hubei) Co., Ltd
  • Daphnetin pictures
  • Daphnetin
    486-35-1
  • US $0.00 / mg
  • ≥98%(HPLC)
  • Shanghai Standard Technology Co., Ltd.
7,8-DIHYDROXY-2H-1-BENZOPYRAN-2-ONE 7,8-DIHYDROXY-CHROMEN-2-ONE 7,8-DIHYDROXYCOUMARIN AKOS 213-37 7,8-dihydroxy-2h-1-benzopyran-2-on 7,8-dihydroxy-coumari DAPHNETIN 7,8-Diydroxycoumarin Daphenetin Daphetin Daphnetin, froM Daphne koreana DAPHNETIN(P) 7,8-DIHYDROXYCOUMARIN (DAPHNETIN) 2H-1-Benzopyran-2-one, 4,8-dihydroxy- Daphnetin,7,8-Dihydroxycoumarin Daphnetol 7,8-dihydroxy-2H-benzopyr... 7,8-dihydroxy-2H-benzopyran-2-one 7,8-dihydroxy-2H-chroMen-2-one 7,8-dihydroxy-1-benzopyran-2-one Daphnetin, 98%, from Daphne koreana Daphnetin> 2H-1-Benzopyran-2-one, 7,8-dihydroxy- Daphnetin,HPLC≥98% 7,8-Dihydroxycoumarin ISO 9001:2015 REACH Daphnetin, 97%+ 7,8-Dihydroxycumarin Daphnetin, ≥ 90.0% 486-35-1 207-632-8 Biochemicals and Reagents BioChemical Cell Biology Cell Signaling and Neuroscience Fluorescent Probes, Labels, Particles and Stains Fluorescent Labels Serine/Threonine Kinase Inhibitors Kinase/Phosphatase Biology Other Fluorescent Labels Protein Kinases (PK) Inhibitors Coumarins DNA/RNA Synthesis chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Pharmaceutical Raw Materials