TYRPHOSTIN A25
- CAS No.
- 118409-58-8
- Chemical Name:
- TYRPHOSTIN A25
- Synonyms
- AG 82;RG-50875;TYRPHOSTIN 25;TYRPHOSTIN A25;TYROPHOSTIN A25;TYRPHOSTIN AG 82;TYRPHOSTIN RG 50875;RARECHEM AL BX 0070;TYRPHOSTIN A25 99+%;TYRPHOSTIN A25 USP/EP/BP
- CBNumber:
- CB1178038
- Molecular Formula:
- C10H6N2O3
- Molecular Weight:
- 202.17
- MDL Number:
- MFCD00133900
- MOL File:
- 118409-58-8.mol
| Melting point | ~220°C dec. |
|---|---|
| Boiling point | 500.8±50.0 °C(Predicted) |
| Density | 1.569±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >50 mg/mL, clear, yellow to orange |
| pka | 7.10±0.23(Predicted) |
| form | Dark yellow solid |
| color | Yellow Green |
| Stability | Light Sensitive |
| CAS DataBase Reference | 118409-58-8 |
| FDA UNII | C878BF87UY |
TYRPHOSTIN A25 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10010312 | AG 82 ≥95% | 118409-58-8 | 5mg | $28 | 2024-03-01 | Buy |
| Cayman Chemical | 10010312 | AG 82 ≥95% | 118409-58-8 | 10mg | $50 | 2024-03-01 | Buy |
| Cayman Chemical | 10010312 | AG 82 ≥95% | 118409-58-8 | 25mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 10010312 | AG 82 ≥95% | 118409-58-8 | 50mg | $207 | 2024-03-01 | Buy |
| TRC | T925000 | Tyrphostin25 | 118409-58-8 | 5mg | $50 | 2021-12-16 | Buy |
TYRPHOSTIN A25 Chemical Properties,Uses,Production
Chemical Properties
Yellow Green Powder
Uses
An inhibitor of epidermal growth factor receptor tyrosine kinase activity and has a reported IC50 of 15 μM for the autophosphorylation of the EGF-receptor.
Uses
An inhibitor of epidermal growth factor receptor tyrosine kinase activity and has a reported IC50 of 15 for the autophosphorylation of the EGF-receptor
Definition
ChEBI: 2-[(3,4,5-trihydroxyphenyl)methylidene]propanedinitrile is a benzenetriol.
General Description
A cell-permeable, reversible, and competitive inhibitor of substrate binding on protein tyrosine kinases. Inhibits epidermal growth factor receptor tyrosine kinase (IC50 = 3 μM) and the GTPase activity of transducin (IC50 = 7 μM). Blocks the induction of inducible nitric oxide synthase in glial cells. Induces apoptosis in human leukemic cell lines. Also reported to inhibit guanylyl cyclase.
Biological Activity
ag-82 is a cell-permeable, reversible, and competitive inhibitor of tyrosine kinase and epidermal growth factor (egf) receptor.protein tyrosine kinases (ptks) have been involved in regulating cell proliferation, cell differentiation, and signaling processes in the immune system. dysfunction of protein tyrosine kinases result in inflammatory responses and diseases including cancer, atherosclerosis, and psoriasis [2]. the epidermal growth factor receptor (egfr) is a transmembrane glycoprotein. activation of egfr results in autophosphorylation of receptor tyrosine kinase and has been involved in regulating cellular proliferation, differentiation, and survival. overexpression of egfr has been identified in a variety of tumor cell lines and has been associated with poor prognosis and decreased survival [3].in the human epidermoid carcinoma cell line a431, ag-82 inhibited the activity of epidermal growth factor receptor kinase with an ic50 value of 3 μm [1]. ag-82 inhibited the gtpase activity of transducin with an ic50 of 7 μm. ag-82 inhibited neuromedin b-induced phosphorylation of p125fak (focal adhesion kinase). ag-82 blocked the induction of inducible nitric oxide synthase in glial cells and induced apoptosis in human leukemic cell lines.
Biochem/physiol Actions
Cell permeable: yes
References
[1] gazit a, yaish p, gilon c, et al. tyrphostins i: synthesis and biological activity of protein tyrosine kinase inhibitors[j]. journal of medicinal chemistry, 1989, 32(10): 2344-2352.
[2] levitzki a, gazit a. tyrosine kinase inhibition: an approach to drug development[j]. science, 1995, 267(5205): 1782.
[3] herbst r s. review of epidermal growth factor receptor biology[j]. international journal of radiation oncology biology physics, 2004, 59(2): s21-s26.
TYRPHOSTIN A25 Preparation Products And Raw materials
Raw materials
Preparation Products
TYRPHOSTIN A25 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29016 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9664 | 60 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9445 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55827 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |