GALANIN (2-11) PORCINE, RAT
- CAS No.
- 367518-31-8
- Chemical Name:
- GALANIN (2-11) PORCINE, RAT
- Synonyms
- AR-M 1896;GALANIN (2-11);Galanin (2-11) (AR-M 1896);GALANIN (2-11) PORCINE, RAT;TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-NH2;H-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-NH2;L-Leucinamide, L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-
- CBNumber:
- CB1205136
- Molecular Formula:
- C54H81N13O14
- Molecular Weight:
- 1136.3
- MDL Number:
- MFCD05664726
- MOL File:
- 367518-31-8.mol
- MSDS File:
- SDS
GALANIN (2-11) PORCINE, RAT price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G8293 | Galanin (2-11) porcine, rat ≥97% (HPLC), lyophilized powder | 367518-31-8 | 500μG | $564 | 2024-03-01 | Buy |
| Alfa Aesar | J66796 | Galanin (2-11) | 367518-31-8 | 0.5mg | $79.9 | 2021-12-16 | Buy |
| Alfa Aesar | J66796 | Galanin (2-11) | 367518-31-8 | 1mg | $131 | 2021-12-16 | Buy |
| Usbiological | 254662 | AR-M 1896 | 367518-31-8 | 1mg | $602 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PEP0003903 | GALANIN (2-11) (PORCINE, RAT) 95.00% | 367518-31-8 | 1MG | $774.95 | 2021-12-16 | Buy |
GALANIN (2-11) PORCINE, RAT Chemical Properties,Uses,Production
Biological Activity
binding ic50: 1.76 nm for rgalr2; 879 nm for hgalr1galanin is a 29-aa neuropeptide with a complex role in pain processing. galanin receptor subtypes are present in dorsal root ganglia and spinal cord with a differential distribution. three galanin receptors, galr1, galr2 and galr3, have been identified and cloned. ar-m1896 is a specific galanin r2 (galr2) agonist.
in vitro
additional removal of the glycine residue in position 1 resulted in ar-m1896 with almost unchanged galr2 affinity and functional activity, and 500-fold selectivity for galr2-rs over galr1-rs. this compound represents a truly galr2-selective galanin analog and, thus, could be used as a pharmacological tool to differentiate between these two receptors [1].
in vivo
in normal rats mechanical and cold allodynia of the hindpaw are induced by intrathecal infusion of low-dose galanin. the same effect is seen with equimolar doses of ar-m1896 or ar-m961 (an agonist both at galr1 and galr2 receptors). in allodynic bennett model rats, the mechanical threshold dose-dependently increased after intrathecal injection of a high ar-m961dose, whereas no effect was observed in the control or ar-m1896 group. no effect of either compounds was observed in nonallodynic bennett model rats [1].
References
[1] liu hx, brumovsky p, schmidt r, brown w, payza k, hodzic l, pou c, godbout c, hökfelt t. receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via galr1 and galr2 receptors. proc natl acad sci u s a. 2001 aug 14;98(17):9960-4.
GALANIN (2-11) PORCINE, RAT Preparation Products And Raw materials
Raw materials
Preparation Products
GALANIN (2-11) PORCINE, RAT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Hangzhou Go Top Peptide Biotech | 0571-88211921 | sales1@gotopbio.com | CHINA | 2609 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | kathy@hbyinsheng.com | China | 3582 | 58 |
| Nanjing TGpeptide | +86-13347807150 +86-13347807150 | support@tgpeptide.com | China | 3279 | 58 |
| Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2944 | 58 |
View Lastest Price from GALANIN (2-11) PORCINE, RAT manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-23 | Galanin (2-11)
367518-31-8
|
US $1.00 / KG | 1g | Min98% HPLC | g/kg /ton | Career Henan Chemical Co |
-
- Galanin (2-11)
367518-31-8
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co
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