(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
- CAS No.
- 915095-94-2
- Chemical Name:
- (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
- Synonyms
- EMpagliflozin iMpurity C;(S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene;]phenoxy}oxoL;oro-5-iodophenyL;(3S)-3-{4-[(2-chL;Englitin Impurity 28;Empagliflozin Impurity 110;Empagliflozin Intermediate1;(3S)-3-[4-[(2-Chloro-5-iodophenyl) methyl] phenc;1-chloro-2-(4-(cyclopentyloxy)benzyl)-4-iodobenzene
- CBNumber:
- CB12657939
- Molecular Formula:
- C17H16ClIO2
- Molecular Weight:
- 414.67
- MDL Number:
- MFCD28098707
- MOL File:
- 915095-94-2.mol
- MSDS File:
- SDS
Boiling point | 476.0±45.0 °C(Predicted) |
---|---|
Density | 1.578±0.06 g/cm3 (20 ºC 760 Torr) |
storage temp. | 2-8°C(protect from light) |
solubility | DMSO, Methanol (Slightly, Sonicated) |
form | Solid |
color | White to Off-White |
InChI | InChI=1S/C17H16ClIO2/c18-17-6-3-14(19)10-13(17)9-12-1-4-15(5-2-12)21-16-7-8-20-11-16/h1-6,10,16H,7-9,11H2/t16-/m0/s1 |
InChIKey | YLUHNGIWRCCQMQ-INIZCTEOSA-N |
SMILES | O1CC[C@H](OC2=CC=C(CC3=CC(I)=CC=C3Cl)C=C2)C1 |
CAS DataBase Reference | 915095-94-2 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
AK Scientific | 9598AF | (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan | 915095-94-2 | 1g | $39 | 2021-12-16 | Buy |
AK Scientific | J95043 | (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan | 915095-94-2 | 5g | $88 | 2021-12-16 | Buy |
SynQuest Laboratories | 2H10-M-S0 | (3S)-3-{4-[(2-Chloro-5-iodophenyl)methyl]phenoxy}oxolane 97.0% | 915095-94-2 | 250mg | $115 | 2021-12-16 | Buy |
AK Scientific | 9598AF | (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan | 915095-94-2 | 5g | $118 | 2021-12-16 | Buy |
AK Scientific | 9598AF | (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan | 915095-94-2 | 10g | $189 | 2021-12-16 | Buy |
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Chemical Properties,Uses,Production
Physical Form
Solid
Uses
(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran(915095-94-2) can be used as reactant/reagent in preparation of C-?aryl D-?glurofuranoside compounds useful as reference compounds in the quality control of gliflozin type medicine.
Description
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran is a pharmaceutical intermediate compound that is used in the preparation of empagliflozin. Empagliflozin is an inhibitor of sodium-glucose co-transporter protein-2 (SGLT2), which is used in the treatment of type 2 diabetes.
Preparation
0.5 mol of raw material and 0.6 mol of aluminum chloride were added to 2 mol of methanol at a temperature of 20° C, and then 0.6 mol of triethylsilane was added to the mixed solution. The mixture was stirred at 25° C for 1 h.The conversion is determined by HPLC analysis. After the reaction is complete, it is extracted and distilled under reduced pressure.Finally, (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan was obtained through purification.
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Preparation Products And Raw materials
Raw materials
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Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
SyncoZymes (Shanghai) Co., Ltd., | +86-021-68187180-811 +86-13681683526 | lchen@syncozymes.com | China | 188 | 58 |
Shanghai Rochi Pharmaceutical Co.,Ltd. | 21-38751876 +8615000076078 | info@rochipharma.com | China | 431 | 58 |
Porton Pharma Solutions Ltd. | China | 56 | 58 | ||
Jinan Dexinjia Bio&Tech Co., Ltd | +86-0531-82375893 +86-15064117275 | sales@jndxj.com | China | 1265 | 58 |
Suzhou Nordica Biopharma CO.,LTD | +8618136148818 | anna.ran@nordicabio.com | China | 298 | 58 |
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 988 | 58 |
Shanghai Joiny Pharmaceutical Co.,LTD | +8613681955282 | gyd@joiny-pharma.com | China | 253 | 58 |
HangZhou RunYan Pharma Technology Co.,LTD. | +8618882027439 | sales2@runyanpharma.com | China | 304 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 990 | 58 |
View Lastest Price from (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-20 | Empagliflozin Intermediate
915095-94-2
|
US $0.00-0.00 / g | 10000g | 99.0%min. HPLC | 1000kg | HangZhou RunYan Pharma Technology Co.,LTD. | ||
2024-09-20 | (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
915095-94-2
|
US $0.00-0.00 / kg | 1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd | ||
2024-09-20 | (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
915095-94-2
|
US $0.00 / Kg/Drum | 10g | 99% | 50mt | Jinan Finer Chemical Co., Ltd |
- Empagliflozin Intermediate
915095-94-2
- US $0.00-0.00 / g
- 99.0%min. HPLC
- HangZhou RunYan Pharma Technology Co.,LTD.
- (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
915095-94-2
- US $0.00-0.00 / kg
- 98%
- Nanjing Fred Technology Co., Ltd
- (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
915095-94-2
- US $0.00 / Kg/Drum
- 99%
- Jinan Finer Chemical Co., Ltd
915095-94-2((S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran)Related Search:
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