4-Amino-3-chlorophenol
- CAS No.
- 17609-80-2
- Chemical Name:
- 4-Amino-3-chlorophenol
- Synonyms
- 4-amino-3-chloro-pheno;3-chloro-4-aminophenol;lenvaint-G;Brn 2802558;synthesis-023;synthesis-1-013;Einecs 241-583-3;4-AMINO-3-CHLOROPHENOL;lenvatinib intermediate;AMINO(4-)-3-CHLOROPHENOL
- CBNumber:
- CB1266045
- Molecular Formula:
- C6H6ClNO
- Molecular Weight:
- 143.57
- MDL Number:
- MFCD00801116
- MOL File:
- 17609-80-2.mol
- MSDS File:
- SDS
Melting point | 159-160℃ |
---|---|
Boiling point | 287.3±25.0 °C(Predicted) |
Density | 1.406±0.06 g/cm3(Predicted) |
RTECS | SJ5710000 |
storage temp. | 2-8°C(protect from light) |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Crystalline Powder |
pka | 9.26±0.18(Predicted) |
color | White |
Stability | Hygroscopic |
InChI | InChI=1S/C6H6ClNO/c7-5-3-4(9)1-2-6(5)8/h1-3,9H,8H2 |
InChIKey | PNLPXABQLXSICH-UHFFFAOYSA-N |
SMILES | C1(O)=CC=C(N)C(Cl)=C1 |
CAS DataBase Reference | 17609-80-2(CAS DataBase Reference) |
EWG's Food Scores | 1 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H312-H315-H319-H332-H335 | |||||||||
Precautionary statements | P261-P280-P304+P340-P305+P351+P338-P405-P501a | |||||||||
HazardClass | 6.1 | |||||||||
HS Code | 2922290090 | |||||||||
NFPA 704 |
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4-Amino-3-chlorophenol price More Price(23)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Alfa Aesar | H66310 | 4-Amino-3-chlorophenol, 95% | 17609-80-2 | 1g | $293 | 2023-06-20 | Buy |
Alfa Aesar | H66310 | 4-Amino-3-chlorophenol, 95% | 17609-80-2 | 250mg | $88.9 | 2021-12-16 | Buy |
TRC | A601735 | 4-Amino-3-chlorophenol | 17609-80-2 | 250mg | $45 | 2021-12-16 | Buy |
TRC | A601735 | 4-Amino-3-chlorophenol | 17609-80-2 | 1g | $55 | 2021-12-16 | Buy |
SynQuest Laboratories | 4656-5-1F | 4-Amino-3-chlorophenol | 17609-80-2 | 5G | $114 | 2021-12-16 | Buy |
4-Amino-3-chlorophenol Chemical Properties,Uses,Production
Chemical Properties
Light yellow solid
Uses
4-Amino-3-Chlorophenol acts as a synthetic reagent for the preparation of Benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer''s disease treatment.
Application
The 4-amino-3-chlorophenol is a crucial intermediate for preparing a tyrosine kinase inhibitor, tivozanib, and a late liver cancer drug, lenvatinib. As a crucial pharmaceutical chemical intermediate, 4-amino-3-chlorophenol is widely applied to the design and synthesis of medicaments for resisting tumors, cardiovascular diseases, neurological diseases, and the like.
Synthesis
Starting from o-chloronitrobenzene with introducing hydroxyl groups in the presence of strong acids and molybdenum salts as catalysts could synthesize 4-amino-3-chlorophenol. Besides, using m-chlorophenol as a starting material and introducing hydroxyl on a benzene ring through diazotization and coupling also could synthesize 4-Amino-3-chlorophenol.
4-Amino-3-chlorophenol Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hangzhou Qiwei Pharmatech Co.,Ltd | 13282840061 | mw@qwpharmatech.com | China | 109 | 58 |
Cangzhou Kangrui Pharma Tech Co. Ltd., | +8618632776803 | cangzhoukangrui@126.com | China | 733 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3878 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5895 | 58 |
Jinan Million Pharmaceutical Co., Ltd | 0531-68659554 +8613031714605 | info@millionpharm.com | China | 207 | 58 |
Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 885 | 50 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 | bj1@bj-chem.com | China | 299 | 55 |
View Lastest Price from 4-Amino-3-chlorophenol manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-26 | 4-Amino-3-Chlorophenol
17609-80-2
|
US $11.00 / KG | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | ||
2024-09-26 | 4-Amino-3-chlorophenol
17609-80-2
|
US $1.00-0.50 / kg | 1kg | 99% | 200 | Jinan Million Pharmaceutical Co., Ltd | ||
2024-09-23 | 4-Amino-3-chlorophenol
17609-80-2
|
US $0.00-0.00 / kg | 1kg | ≥98% by HPLC | 100kg | Zison Pharmaceutical (Shandong) Co., Ltd. |
- 4-Amino-3-Chlorophenol
17609-80-2
- US $11.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
- 4-Amino-3-chlorophenol
17609-80-2
- US $1.00-0.50 / kg
- 99%
- Jinan Million Pharmaceutical Co., Ltd
- 4-Amino-3-chlorophenol
17609-80-2
- US $0.00-0.00 / kg
- ≥98% by HPLC
- Zison Pharmaceutical (Shandong) Co., Ltd.
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