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Tris Base

Chemical Properties Uses of Biology Uses
Tris Base
Tris Base
Chemical Name:
Tris Base
TRIS;THAM;Tham-E;Trizma;riladyl;thamset;TRISMAT;8VTE 1L;Pehanorm;Talatrol
Molecular Formula:
Formula Weight:
MOL File:

Tris Base Properties

Melting point:
167-172 °C(lit.)
Boiling point:
219-220 °C10 mm Hg(lit.)
1,353 g/cm3
Flash point:
storage temp. 
H2O: 4 M at 20 °C, clear, colorless
10.5-12.0(4 m in water, 25 °C)
8.1(at 25℃)
Water Solubility 
550 g/L (25 ºC)
Stable. Incompatible with bases, strong oxidizing agents. Protect from moisture.
CAS DataBase Reference
77-86-1(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Propanediol, 2-amino-2-(hydroxymethyl)-(77-86-1)
EPA Substance Registry System
1,3-Propanediol, 2-amino-2-(hydroxymethyl)- (77-86-1)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39-24/25-23
WGK Germany  2
RTECS  TY2900000
HazardClass  IRRITANT
HS Code  29221980
Hazardous Substances Data 77-86-1(Hazardous Substances Data)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P405 Store locked up.

Tris Base price More Price(73)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1.02408 Tris(hydroxymethyl)aminomethane 77-86-1 1EA $90 2017-11-08 Buy
Sigma-Aldrich 04577 Trizma? base aminopeptidase substrate 77-86-1 250g-f $517 2017-11-08 Buy
TCI Chemical A0321 Tris(hydroxymethyl)aminomethane >99.0%(T) 77-86-1 25g $10 2017-11-08 Buy
TCI Chemical A0321 Tris(hydroxymethyl)aminomethane >99.0%(T) 77-86-1 500g $52 2017-11-08 Buy
Alfa Aesar A18494 Tris(hydroxymethyl)aminomethane, 99% 77-86-1 500g $72.9 2017-11-08 Buy

Tris Base Chemical Properties,Uses,Production

Chemical Properties

White crystal or powder. Melting point 171-172℃, boiling point 219-220℃/1.3kPa, soluble in ethanol and water, slightly soluble in ethyl acetate, benzene, insoluble in ether, carbon tetrachloride,copper,aluminum corrosion effects,irritant.

Uses of Biology

Tris base, also known as THAM, is widely used as a biological buffer or as a component of buffer formulations such as TAE and TBE buffers. Tris has a pKa of 8.06 and is very useful in the biology and biochemistry lab because it has buffering capabilities in the range of the typical physiological pH of most living organisms (pH 7.0-9.0). Tris has been reported to interfere with the activity of a number of enzymes, it should therefore be used carefully when studying proteins.


1, Tris buffer, only nucleic acids and proteins are widely used as solvents.
2, Tris is used for protein crystal growth under different pH conditions.
3, Tris buffer having a low ionic strength can be used nematode (C. elegans) is formed lamin (lamin) intermediate fibers.
4, Tris is a major component of protein electrophoresis buffer.
5, Tris for the preparation of a surfactant, a vulcanization accelerator, and some drug intermediates.
6, Tris titrated also used as standard.

Chemical Properties

White crystalline powder


In the synthesis of surface-active agents, vulcanization accelerators, pharmaceuticals. As emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, leather dressings, textile specialties, polishes, cleaning Compounds, so-called soluble oils. Absorbent for acidic gases. Biological buffer.

Biological Activity

Commonly used laboratory reagent

Tris Base Preparation Products And Raw materials

Raw materials

Preparation Products

Tris Base Suppliers

Global( 413)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 China 19953 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 9974 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 CHINA 1372 55
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37127788 CHINA 497 55
Henan DaKen Chemical CO.,LTD.
+86-371-55541817 CHINA 2900 58
Suzhou yacoo science co.,Ltd 0512-81665519 81667796
0512-87182056 China 100 60
Spectrum Chemical Manufacturing Corp. 021-67601398-808
021-57711696 China 9330 60
Beijing Xinsavi Chemical Technology Co., Ltd. 13717722232
010-56218800 China 4825 56
Codow Chemical Co.,Ltd. +86-20-38056109 / 3892 1903
+86-20-6261 9665 China 18455 55
Zhejiang Haiqiang Chemical Co.,Ltd 0571-86050367 0571-86960370 0571-86050387
0571-86940780 China 469 55

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