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Tris Base

Chemical Properties Uses of Biology Uses

CAS No. 77-86-1
Chemical Name: Tris Base
Synonyms: TRIS;THAM;Tham-E;Trizma;riladyl;thamset;TRISMAT;8VTE 1L;Pehanorm;Talatrol
CBNumber: CB8336488
Molecular Formula: C4H11NO3
Formula Weight: 121.14
MOL File: 77-86-1.mol
Tris Base Property
Melting point : 167-172 °C(lit.)
Boiling point : 219-220 °C10 mm Hg(lit.)
density : 1,353 g/cm3
Fp : 219-220°C/10mm
storage temp. : 2-8°C
solubility : H2O: 4 M at 20 °C, clear, colorless
form : crystalline
color : white
PH: 10.5-12.0(4 m in water, 25 °C)
pka: 8.1(at 25℃)
Water Solubility : 550 g/L (25 ºC)
Sensitive : Hygroscopic
Merck : 14,9772
BRN : 741883
Stability:: Stable. Incompatible with bases, strong oxidizing agents. Protect from moisture.
CAS DataBase Reference: 77-86-1(CAS DataBase Reference)
NIST Chemistry Reference: 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-(77-86-1)
EPA Substance Registry System: 1,3-Propanediol, 2-amino-2-(hydroxymethyl)- (77-86-1)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : Xi
Risk Statements : 36/37/38
Safety Statements : 26-36-37/39-24/25-23
WGK Germany : 2
RTECS : TY2900000
F : 3
TSCA : Yes
HazardClass : IRRITANT
HS Code : 29221980
Hazardous Substances Data: 77-86-1(Hazardous Substances Data)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P405 Store locked up.

Tris Base Chemical Properties,Usage,Production

Chemical Properties
White crystal or powder. Melting point 171-172℃, boiling point 219-220℃/1.3kPa, soluble in ethanol and water, slightly soluble in ethyl acetate, benzene, insoluble in ether, carbon tetrachloride,copper,aluminum corrosion effects,irritant.
Uses of Biology
Tris base, also known as THAM, is widely used as a biological buffer or as a component of buffer formulations such as TAE and TBE buffers. Tris has a pKa of 8.06 and is very useful in the biology and biochemistry lab because it has buffering capabilities in the range of the typical physiological pH of most living organisms (pH 7.0-9.0). Tris has been reported to interfere with the activity of a number of enzymes, it should therefore be used carefully when studying proteins.
Uses
1, Tris buffer, only nucleic acids and proteins are widely used as solvents.
2, Tris is used for protein crystal growth under different pH conditions.
3, Tris buffer having a low ionic strength can be used nematode (C. elegans) is formed lamin (lamin) intermediate fibers.
4, Tris is a major component of protein electrophoresis buffer.
5, Tris for the preparation of a surfactant, a vulcanization accelerator, and some drug intermediates.
6, Tris titrated also used as standard.
Chemical Properties
White crystalline powder
Biological Activity
Commonly used laboratory reagent
Tris Base Preparation Products And Raw materials
Raw materials
Nitromethane Potassium carbonate Paraformaldehyde Palladium Methanol Tris(hydroxymethyl)nitromethane
Preparation Products
Tris Base Suppliers      Global( 395)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd. +86 (0)571-855 867 18
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inquiry@dakenchem.com CHINA 1977 58
Suzhou yacoo science co.,Ltd 0512-81665519(生物医药);0512-816677969(电化学材料)
0512-87182056 service2@yacoo.com.cn China 100 60
Spectrum Chemical Manufacturing Corp. 021-67601398-808
021-57711696 gduan@spectrumchina.net China 9334 60
Beijing Xinsavi Chemical Technology Co., Ltd. 13717722232
010-56218800 xinsavichem@163.com China 4825 56
Codow Chemical Co.,Ltd. +86-20-38056109 / 3892 1903
+86-20-6261 9665 sales@hwhg.com.cn China 18462 55
Zhejiang Haiqiang Chemical Co.,Ltd 0571-86050367 0571-86960370 0571-86050387
0571-86940780 info@chinahaiqiangchem.com China 470 55
Hefei TNJ Chemical Industry Co.,Ltd. +86 (551) 65418684 65418696
+86 (551) 65418697 info@tnjchem.com China 1944 62
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 sale@aladdin-e.com China 28587 65
Nanjing Search Biotech Co., Ltd +86-25-85860978,81682922,13515111588,18905151602
+86-25-85860962 sales@searchbio.com.cn China 176 68
 
77-86-1(Tris Base)Related Search:
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