(1S,2S)-(+)-Pseudoephedrine hydrochloride
- CAS No.
- 345-78-8
- Chemical Name:
- (1S,2S)-(+)-Pseudoephedrine hydrochloride
- Synonyms
- PSEUDOEPHEDRINE HYDROCHLORIDE;PSEUDOEPHEDRINE HCL;sudafed;novafed;a)]-;GRCA;GPR162;sinufed;Otrinol;symptom2
- CBNumber:
- CB1399716
- Molecular Formula:
- C10H16ClNO
- Molecular Weight:
- 201.69
- MDL Number:
- MFCD00058088
- MOL File:
- 345-78-8.mol
| Melting point | 185-188 °C(lit.) |
|---|---|
| alpha | 61 º (c=5, H2O,2dm tube) |
| storage temp. | Refrigerator (+4°C) |
| solubility | Freely soluble in water and in ethanol (96 per cent), sparingly soluble in methylene chloride. |
| pka | 9.22(at 25℃) |
| Merck | 13,8007 |
| BRN | 3915112 |
| LogP | -1.74 at 23℃ and pH7 |
| CAS DataBase Reference | 345-78-8(CAS DataBase Reference) |
| FDA 21 CFR | 310.545; 341.20 |
| EWG's Food Scores | 1 |
| FDA UNII | 6V9V2RYJ8N |
| EPA Substance Registry System | Benzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, hydrochloride, (.alpha.S)- (345-78-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H336 |
| Precautionary statements | P261-P264-P270-P271-P301+P312-P304+P340+P312 |
| Hazard Codes | Xn,T,F |
| Risk Statements | 22-36/37/38-36/38-39/23/24/25-23/24/25-11 |
| Safety Statements | 26-36-24/25-45-36/37-16-7 |
| RIDADR | 1544 |
| WGK Germany | 3 |
| RTECS | UL5950000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29394200 |
| Toxicity | LD50 i.p. in mice: 1.0 mmole/kg (Fairchild, Alles) |
(1S,2S)-(+)-Pseudoephedrine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
white powder
Uses
Non-selective adrenergic agonist; decongestant (nasal). Controlled precursor.
Definition
ChEBI: A hydrochloride that is the monohydrochloride salt of pseudoephedrine.
brand name
Efidac (ALZA); Novafed (Sanofi Aventis); Sudafed (GlaxoSmithKline); Sudafed (Warner Lambert).
Contact allergens
This sympathomimetic a-adrenergic agonist is found in plants of the genus Ephedra (Ephedraceae) and is systemically used as a nasal decongestant. It can induce drug skin reactions such as acute generalized exanthematic pustulosis or generalized eczema.
Clinical Use
Nasal decongestant
Drug interactions
Potentially hazardous interactions with other drugs
Adrenergic neurone blockers: antagonise hypotensive
effect of adrenergic neurone blockers.
Anaesthetics: increased risk of ventricular
arrhythmias with isoflurane.
Antibacterials: risk of hypertensive crisis with
linezolid.
Antidepressants: risk of hypertensive crisis with
MAOIs and moclobemide.
Dopaminergics: avoid concomitant use with
selegiline and rasagiline.
Metabolism
A small amount of pseudoephedrine is hepatically
metabolised by N-demethylation.
It is excreted largely unchanged in the urine with small
amounts of its hepatic metabolite.
Purification Methods
1S,2S-Pseudoephedrine hydrochloride [345-78-8] M 210.7, m 181-182o, 185-188o, [ + 6 1o (c 1 H2O). Crystallise the salt from EtOH. [Beilstein 13 IV 1878.]
(1S,2S)-(+)-Pseudoephedrine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
345-78-8((1S,2S)-(+)-Pseudoephedrine hydrochloride)Related Search:
1of4