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Sulfanilic acid

CAS No.
121-57-3
Chemical Name:
Sulfanilic acid
Synonyms
SULPHANILIC ACID;4-AMINOBENZENESULFONIC ACID;sulfanilic;P-AMINOBENZENESULFONIC ACID;4-aminobenzenesulfonate;SULFANILLIC ACID;Sulphanillic Acid;ANILINE-4-SULFONIC ACID;SULFANILIC ACID ANHYD PWD;4-AMINOBENZENESULPHONIC ACID
CBNumber:
CB1489237
Molecular Formula:
C6H7NO3S
Molecular Weight:
173.19
MDL Number:
MFCD00007886
MOL File:
121-57-3.mol
MSDS File:
SDS
Last updated:2023-09-08 21:17:32

Sulfanilic acid Properties

Melting point >300 °C(lit.)
Boiling point 288 ℃
Density 1.485
vapor pressure 0Pa at 25℃
refractive index 1.5500 (estimate)
storage temp. Store below +30°C.
solubility 10g/l
form solid
pka 3.24(at 25℃)
color White to Off-White
PH 2.5 (10g/l, H2O, 20℃)
Water Solubility 0.1 g/100 mL (20 ºC)
Merck 14,8926
BRN 908765
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey HVBSAKJJOYLTQU-UHFFFAOYSA-N
LogP -2.3 at 25℃
Indirect Additives used in Food Contact Substances SULFANILIC ACID
FDA 21 CFR 176.180
CAS DataBase Reference 121-57-3(CAS DataBase Reference)
FDA UNII 434Z8C2635
NIST Chemistry Reference Benzenesulfonic acid, 4-amino-(121-57-3)
EPA Substance Registry System Sulfanilic acid (121-57-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H317-H319
Precautionary statements  P261-P264-P272-P280-P302+P352-P305+P351+P338
Hazard Codes  C,Xi
Risk Statements  36/38-43-34
Safety Statements  26-36/37/39-45-37-24-36/37
RIDADR  UN 2790 8/PG 3
WGK Germany  1
RTECS  WP3895500
Autoignition Temperature >400 °C
TSCA  Yes
HS Code  29214210
Toxicity LD50 orally in Rabbit: 12300 mg/kg
NFPA 704
0
2 0

Sulfanilic acid price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.22338 Sulfanilic acid for synthesis 121-57-3 100g $34 2024-03-01 Buy
Sigma-Aldrich 8.22338 Sulfanilic acid for synthesis 121-57-3 1kg $91.4 2024-03-01 Buy
Sigma-Aldrich 8.22338 Sulfanilic acid for synthesis 121-57-3 50kg $1040 2024-03-01 Buy
Sigma-Aldrich 251917 Sulfanilic acid ACS reagent, 99% 121-57-3 25g $33.5 2024-03-01 Buy
Sigma-Aldrich 39441 Nitrate Reagent B suitable for microbiology 121-57-3 100mL $45.7 2024-03-01 Buy
Product number Packaging Price Buy
8.22338 100g $34 Buy
8.22338 1kg $91.4 Buy
8.22338 50kg $1040 Buy
251917 25g $33.5 Buy
39441 100mL $45.7 Buy

Sulfanilic acid Chemical Properties,Uses,Production

Synthesize

Sulfanilic acid can be used for the determination of nitrite. Biochemical Research. Organic Synthesis. Sulfanilic acid is an important intermediate of sulfonamide drugs. This product has strong antibacterial effect on hemolytic streptococcus, meningitis and coccus, but due to poor efficacy and high toxicity, it is rarely used for oral administration. It is also rarely used. It is used as an intermediate for the synthesis of other sulfonamides, and is also used as a raw material for the synthesis of agricultural "Huangcaoling" abroad. Sulfanilic acid can also be used as an analytical reagent, such as a reagent for the photometric determination of nitrite and sodium nitroferricyanide. For biochemical research, organic synthesis and pharmaceutical industry. Sulfanilic acid is the main raw material for synthesizing sulfonamides. In addition to preparing crystalline sulfonamides for external anti-inflammatory, it can also synthesize other sulfonamides such as sulfamidine, sulfamethoxazine, and sulfamethazine.

Description

Sulfanilic acid (4-amino benzene sulfonic acid ) is an off-white crystalline solid which finds application in quantitative analysis of nitrate and nitrite ions. The solid acid exists as a zwitterion, and has an unusually high melting point.Sulfanilic acid.jpg

Chemical Properties

greyish-white crystals or powder

Uses

Sulfanilic acid may be used for the functionalization of single-walled carbon nanotubes (SWNTs) with aryl sulfonate groups.

Uses

Sulfanilic Acid (Sulfadimethoxine EP Impurity D) is a toxic metabolite of Tartrazine (T007700). Used as Ehrlich’s reagent, for detecting of nitrites. Antibacterial.

Uses

A toxic metabolite of Tartrazine (T007700). Used as Ehrlich’s reagent, for detecting of nitrites. Antibacterial.

Definition

ChEBI: An aminobenzenesulfonic acid that is aniline sulfonated at the para-position.

Application

As the compound readily form diazo compounds, it is used to make dyes and sulpha drugs . This property is also used for the quantitative analysis of nitrate and nitrite ions by diazonium coupling reaction with N-(1-Naphthyl) ethylene diamine , resulting in an azo dye, and the concentration of nitrate or nitrite ions were deduced from the color intensity of the resulting red solution by colorimetry.
It is also used as a standard in combustion analysis.

General Description

White powder with faint purple tinge. Grayish-white flat crystals. Becomes anhydrous at around 212°F. Low toxicity (used medicinally).

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Sulfanilic acid is an amino acid. Reacts weakly with both acids and bases.

Fire Hazard

Flash point data for Sulfanilic acid are not available, however Sulfanilic acid is probably combustible.

Synthesis

Sulfanilic acid can be produced by sulfonation of aniline.

Purification Methods

Crystallise the acid (as dihydrate) from boiling water. Dry it at 105o for 2-3hours, then over 90% H2SO4 in a vacuum desiccator. The S-benzylisothiuronium salt has m 187o (from aqueous EtOH). [Beilstein 14 IV 2655.]

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View Lastest Price from Sulfanilic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sulfanilic acid pictures 2023-09-08 Sulfanilic acid
121-57-3
US $1.00 / kg 1kg 99.00% 20tons Hebei Yanxi Chemical Co., Ltd.
Sulfanilic acid pictures 2023-06-20 Sulfanilic acid
121-57-3
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
Sulfanilic acid pictures 2023-05-30 Sulfanilic acid
121-57-3
US $5.00-2.00 / KG 1KG 99% 10000kg Hebei Guanlang Biotechnology Co,.LTD
  • Sulfanilic acid pictures
  • Sulfanilic acid
    121-57-3
  • US $5.00-2.00 / KG
  • 99%
  • Hebei Guanlang Biotechnology Co,.LTD
Sulfanilic acid puriss. p.a., >=99.0% (T) Sulfanilic acid Vetec(TM) reagent grade, 99% BES SODIUM SALT HIGH PURITY GRADE p-Anilinesulfonic acid anhydrous DNA MW MARKER 1KB LADDER 4-SULFOANILINE 4-ANILINESULFONIC ACID SUFANILIC ACID SULFANILIC ACID SULFANILIC ACID TS P-SULFANILIC ACID P-ANILINESULFONIC ACID NITRATE REAGENT B LB POWDER NON ANIMAL ORIGIN 5X1 L 4-Aminobenzenesulfonic acid Aniline-4-sulfonic acid p-Aminobenzene sulfonic acid anhydrous 4-Sulfoaniline 4-Anilinesulfonic acid p-Anilinesulfonic Acid Sulfanilicacid,anhydrous Sulfanilicacidanhydrous Sulfanilsaeure Sulfanilic acid 99.0+ % for analysis Sulfanilic acid 99+ % SULFANILIC ACID, 99%, A.C.S. REAGENT SULFANILIC ACID STD SOLUTION 0.1 MOL/L N29, 1 L P-AMINOBENZENS SULFONIC ACID SulphanilicAcidA.R. SulphanilicAcid,>98% SulfanilicAcidMonohydrate SulphanilicAcidGr SULFANILIC ACID ANHYDROUS ACS REAGENT ANILINE P-SULFONIC ACID Sulfanilic Acid, Anhydrous, Reagent 4-aminobenzenesulphonic acid,sulphanilic acid Sulfanilic acid solution,4-Aminobenzenesulfonic acid Sulfanilic acid,4-Aminobenzenesulfonic acid, Aniline-4-sulfonic acid Sulfanilic acid, reagent grade, ACS Sulfanilic Acid Solution [for Spray] Sulfanilic Acid (200 mg) Sulfanilic acid, ACS reagent Sulfanilic acid, 99% 100GR Sulfanilic acid (8CI) 1-AMinobenzene-4-sulfonic Acid 4-AMinophenylsulfonic Acid NSC 7170 p-Sulfoaniline 4-Aminobenzenesulfonic Acid p-Anilinesulfonic Acid 4-Sulfoaniline SULFANILIC ACID GR FOR ANALYSIS ACS SULFANILIC ACID STANDARD FOR ELEMENTAL A Aniline-p-sulphonic acid aniline-p-sulphonicacid Kyselina sulfanilova kyselinasulfanilova p-Aminophenylsulfonic acid p-aminophenylsulfonicacid SulfonamineAcid Sulfanilic acid, reagent ACS SULFANILIC ACID, ANHYDROUS REAGENT (ACS) Benzenesulfonic acid, 4-amino- sulfanilic acid solution sulfanilic acid, acs