ChemicalBook >> CAS DataBase List >>4-Difluoromethoxy-3-hydroxybenzaldehyde
4-Difluoromethoxy-3-hydroxybenzaldehyde
- CAS No.
- 151103-08-1
- Chemical Name:
- 4-Difluoromethoxy-3-hydroxybenzaldehyde
- Synonyms
- 4-DifL;Roflumilast impurity 19;uoromethoxy-3-hydroxybenzaL;3-Hydroxy-4-diflouromethylbenzaldehyde;4-DIFLUOROMETHOXY-3-HYDROXYBENZALDEHYDE;3-hydroxy-4-difluoroMethoxy benzaldehyde;4-(Difluoiromethoxy)-3-Hydroxybenzaldehyde;Benzaldehyde,4-(difluoroMethoxy)-3-hydroxy-;4-(Difluoromethoxy)-3-hydroxybenzaldehyde97%;4-(Difluoromethoxy)-3-hydroxybenzaldehyde 97%
- CBNumber:
- CB2266224
- Molecular Formula:
- C8H6F2O3
- Molecular Weight:
- 188.13
- MDL Number:
- MFCD04406687
- MOL File:
- 151103-08-1.mol
- MSDS File:
- SDS
Last updated:2024-09-02 10:43:37
Melting point | 85-90°C |
---|---|
Boiling point | 280.6±35.0 °C(Predicted) |
Density | 1.395±0.06 g/cm3(Predicted) |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
pka | 7.85±0.35(Predicted) |
color | White |
InChI | InChI=1S/C8H6F2O3/c9-8(10)13-7-2-1-5(4-11)3-6(7)12/h1-4,8,12H |
InChIKey | ZLIKNROJGXXNJG-UHFFFAOYSA-N |
SMILES | C(=O)C1=CC=C(OC(F)F)C(O)=C1 |
CAS DataBase Reference | 151103-08-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS09 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335-H411 | |||||||||
Precautionary statements | P261-P273-P305+P351+P338 | |||||||||
Hazard Codes | Xi,Xn | |||||||||
Risk Statements | 36/37/38-51-22 | |||||||||
Safety Statements | 26-36/37/39 | |||||||||
WGK Germany | 3 | |||||||||
Hazard Note | Irritant | |||||||||
HS Code | 2913000090 | |||||||||
NFPA 704 |
|
4-Difluoromethoxy-3-hydroxybenzaldehyde price More Price(34)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemical | D4505 | 4-(Difluoromethoxy)-3-hydroxybenzaldehyde | 151103-08-1 | 5G | $165 | 2024-03-01 | Buy |
TRC | D446005 | 4-(Difluoromethoxy)-3-hydroxybenzaldehyde | 151103-08-1 | 10g | $130 | 2021-12-16 | Buy |
TRC | D446005 | 4-(Difluoromethoxy)-3-hydroxybenzaldehyde | 151103-08-1 | 1g | $55 | 2021-12-16 | Buy |
TRC | D446005 | 4-(Difluoromethoxy)-3-hydroxybenzaldehyde | 151103-08-1 | 25g | $280 | 2021-12-16 | Buy |
Apolloscientific | PC8950 | 4-(Difluoromethoxy)-3-hydroxybenzaldehyde 97% | 151103-08-1 | 25g | $350 | 2021-12-16 | Buy |
4-Difluoromethoxy-3-hydroxybenzaldehyde Chemical Properties,Uses,Production
Description
4-Difluoromethoxy-3-hydroxybenzaldehyde is an organofluorine compound, mainly used as an intermediate in organic synthesis. It is used in the synthesis of the impurity N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-3-hydroxybenzamide isolated from roflumilast crude[1].
Chemical Properties
4-Difluoromethoxy-3-hydroxybenzaldehyde is white powder
Uses
4-Difluoromethoxy-3-hydroxybenzaldehyde is a phenyl alkyl ketone derivative used in the preparation of phosphodiesterase-4 (PDE4) inhibitors.
References
[1] YAN LIN. Isolation, synthesis and structure confirmation of the impurity in crude roflumilast product[J]. Research on Chemical Intermediates, 2012. DOI:10.1007/s11164-012-0823-3.
4-Difluoromethoxy-3-hydroxybenzaldehyde Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Global( 296)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hefei TianRui Pharmaceutical Chemical Co., Ltd. | +86-0551-68665055 +86-+86-18616906106 | sales@trywchem.com | China | 148 | 58 |
Shanghai Famo Biotech Co Ltd | +86-36680037 +86-18550473860 | mayan@famobiotech.com;sales@famobiotech.com | China | 528 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 973 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
View Lastest Price from 4-Difluoromethoxy-3-hydroxybenzaldehyde manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-20 | 4-Difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1
|
US $30.00 / kg | 20kg | 99% | 2000kg | hebei hongtan Biotechnology Co., Ltd | ||
2024-09-14 | 4-Difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1
|
US $0.00 / kg | 1kg | 99% | 200KG | Shanghai Joiny Pharmaceutical Co.,LTD | ||
2023-04-20 | 4-DifluoroMethoxy-3-hydroxybenzaldehyde
151103-08-1
|
US $0.00-0.00 / KG | 5KG | 99.9 | 1.5 tons | Hefei TianRui Pharmaceutical Chemical Co., Ltd. |
- 4-Difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1
- US $30.00 / kg
- 99%
- hebei hongtan Biotechnology Co., Ltd
- 4-Difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1
- US $0.00 / kg
- 99%
- Shanghai Joiny Pharmaceutical Co.,LTD
- 4-DifluoroMethoxy-3-hydroxybenzaldehyde
151103-08-1
- US $0.00-0.00 / KG
- 99.9
- Hefei TianRui Pharmaceutical Chemical Co., Ltd.
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4-(Difluoromethoxy)-3-hydroxybenzaldehyde 97%
4-(Difluoromethoxy)-3-hydroxybenzaldehyde97%
3-hydroxy-4-difluoroMethoxy benzaldehyde
4-DIFLUOROMETHOXY-3-HYDROXYBENZALDEHYDE
Roflumilast impurity 19
4-DifL
uoromethoxy-3-hydroxybenzaL
4-DIFLUOROMETHOXY-3-HYDROXYBENZALDEHYDE 151103-08-1
4-(Difluoiromethoxy)-3-Hydroxybenzaldehyde
151103-08-1
Roflumilast interemdiate
Aromatics
Intermediates
Aldehydes
Phenyls & Phenyl-Het
Phenyls & Phenyl-Het
Intermediate