CYTOCHALASIN J
- CAS No.
- 53760-20-6
- Chemical Name:
- CYTOCHALASIN J
- Synonyms
- CYTOCHALASIN J;deacetylcytochalasin H;cytochalasin J from A phomopsis species;1H-Cycloundec[d]isoindol-1-one, 2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-6,12,15-trihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-, (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-
- CBNumber:
- CB2402529
- Molecular Formula:
- C28H37NO4
- Molecular Weight:
- 451.6
- MDL Number:
- MFCD00077708
- MOL File:
- 53760-20-6.mol
| Melting point | 138°C (dec.) |
|---|---|
| Boiling point | 679.5±55.0 °C(Predicted) |
| Density | 1.20±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in ethanol;Soluble in methanol;Soluble in DMSO;Soluble in dimethyl formamide |
| form | white lyophilisate |
| pka | 13.03±0.70(Predicted) |
| color | White |
| Stability | Light Sensitive |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H310-H351-H330-H300 | |||||||||
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 26/27/28-63-40 | |||||||||
| Safety Statements | 28-36/37-45-36/37/39-22 | |||||||||
| RIDADR | UN 3462 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | HA5306500 | |||||||||
| F | 10 | |||||||||
| NFPA 704 |
|
CYTOCHALASIN J price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18443 | Cytochalasin J ≥95% | 53760-20-6 | 1mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 18443 | Cytochalasin J ≥95% | 53760-20-6 | 5mg | $401 | 2024-03-01 | Buy |
| TRC | C998718 | CytochalasinJ | 53760-20-6 | 2.5mg | $165 | 2021-12-16 | Buy |
| Adipogen Life Sciences | BVT-0450-M001 | CytochalasinJ ≥98%(NMR) | 53760-20-6 | 1mg | $95 | 2021-12-16 | Buy |
| ApexBio Technology | C4390 | CytochalasinJ | 53760-20-6 | 1mg | $117 | 2021-12-16 | Buy |
CYTOCHALASIN J Chemical Properties,Uses,Production
Uses
Cytochalasin J is a cell-permeable fungal toxin used in actin polymerization studies and cytological research.
Biological Activity
cytochalasin j can alter mitotic spindle microtubule organization and kinetochore structure.the cytochalasins are cell-permeable fungal metabolites inhibiting actin polymerization, which can alter diverse processes including cell movement, growth, phagocytosis, degranulation, and secretion.
in vitro
cytochalasin j was identified as a deacetylated analog of cytochalasin h that weakly inhibited actin assembly but significantly altered mitotic spindle microtubule organization and kinetochore structure [1]. in a previous study, cytochalasin j treatment of prometaphase cells reduced the number of kmts and the size and organization of the kinetochore lamina. moreover, in approximately 30% of cells treated with cytochalasin j, the failure of a small number of chromosomes to attach to spindle fibers could be documented. these chromosomes showed a significant change in the organization of the kinetochore laminae. light microscopic analyses of cells treated with cytochalasin j revealed loss of chromosome congression, with chromsomes usually located at the periphery of the spindle. cells treated with 10 microg/ml cytochalasin j for 10 min and released into tissue culture medium showed a resumption of chromosome motion within a few minutes, both during congression and anaphase [2].
storage
+4°C
References
[1] walling, e. a.,krafft, g.a. and ware, b.r. actin assembly activity of cytochalasins and cytochalasin analogs assayed using fluorescence photobleaching recovery. archives of biochemistry and biophysics 264(1), 321-332 (1988).
[2] wrench, g. a. and snyder, j.a. cytochalasin j treatment significantly alters mitotic spindle microtubule organization and kinetochore structure in ptk1 cells. cell motility and the cytoskeleton 36(2), 112-124 (1997).
CYTOCHALASIN J Preparation Products And Raw materials
Raw materials
Preparation Products
CYTOCHALASIN J Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006608290; 18621169109 | market03@meryer.com | China | 40241 | 62 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6011 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 18521732826; | market@aladdin-e.com | China | 25015 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2981 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| UHN Shanghai Research & Development Co., Ltd. | 021-58958002 18930822973 | xiaoyangw@gmail.com | China | 2129 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |