ChemicalBook >> CAS DataBase List >>Olprinone
Olprinone
- CAS No.
- 106730-54-5
- Chemical Name:
- Olprinone
- Synonyms
- LOPRINONE;OLPRINONE;Olprinone [inn];Olprinone USP/EP/BP;Olprinone(Loprinone);3-phenylmethoxy-1-cyclobutanecarboxylic acid ethyl ester;1,2-dihydro-5-imidazo(1,2-alpha)pyridin-6-yl-6-methyl-2-oxonicotinonitrile;1，2-Dihydro-5-imidazo[1，2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile;3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-;1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile
- CBNumber:
- CB2438515
- Molecular Formula:
- C14H10N4O
- Molecular Weight:
- 250.26
- MDL Number:
- MFCD25541649
- MOL File:
- 106730-54-5.mol
- MSDS File:
- SDS
Last updated:2023-05-18 11:31:10
| Melting point | >300° |
|---|---|
| Density | 1.34±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO |
| form | Powder |
| pka | 6.59±0.10(Predicted) |
| CAS DataBase Reference | 106730-54-5(CAS DataBase Reference) |
| FDA UNII | 4Y8BMI9YGC |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Olprinone price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 3950AH | Olprinone | 106730-54-5 | 100mg | $157 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0003677 | OLPRINONE 95.00% | 106730-54-5 | 10MG | $263.55 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0003677 | OLPRINONE 95.00% | 106730-54-5 | 100MG | $1030.84 | 2021-12-16 | Buy |
| Ambeed | A168914 | 5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 98+% | 106730-54-5 | 5mg | $62 | 2021-12-16 | Buy |
| Ambeed | A168914 | 5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 98+% | 106730-54-5 | 10mg | $80 | 2021-12-16 | Buy |
Olprinone Chemical Properties,Uses,Production
Description
Oprinone is an injection developed by Japan Co., Ltd. for the treatment of acute heart failure. It is a specific PDEⅢ inhibitor that selectively blocks cAMP and has high selectivity for the inhibition of human cardiac PDEⅢ.
Uses
Olprinone is used in the treatment of acute myocardial insufficiency.
Definition
ChEBI: Olprinone is a member of bipyridines.
Side effects
1. In the treatment of heart failure, the main adverse reactions of opprinone are manifested in the circulatory system, including premature ventricular contraction, tachycardia, increased ventricular tachyarrhythmia, and increased heart rate. Electric monitoring;
2. As a vasodilator, patients with renal insufficiency should use it in low doses. Long-term oral administration may lead to increased long-term mortality due to large adverse reactions, so it is only used for a short period of time.
Synthesis
4-(Dimethylamino)-3-(pyrimido[1,2-α]pyridin-6-yl)-3-buten-2-one and cyanoacetamide in dimethylformamide at 80~ Heating at 90°C for 12h to obtain Operinone.
Olprinone Preparation Products And Raw materials
Olprinone Suppliers
Global( 125)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9320 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
View Lastest Price from Olprinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-07 | Olprinone USP/EP/BP
106730-54-5
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-05-10 | Olprinone
106730-54-5
|
US $0.00-0.00 / Kg | 1KG | 99.0% | 500 MT | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | Olprinone
106730-54-5
|
US $0.00 / KG | 1KG | 98% | 150KG | Career Henan Chemical Co |
-
- Olprinone USP/EP/BP
106730-54-5
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Olprinone
106730-54-5
- US $0.00-0.00 / Kg
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- Olprinone
106730-54-5
- US $0.00 / KG
- 98%
- Career Henan Chemical Co
106730-54-5(Olprinone)Related Search:
1of4
1,2-dihydro-5-imidazo(1,2-alpha)pyridin-6-yl-6-methyl-2-oxonicotinonitrile
5-(1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-3-yl)-6-methyl-2-oxo-1h-pyridine-3-carbonitrile
OLPRINONE
5-(Imidazo[1,2-a]pyridine-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
Olprinone [inn]
1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile
LOPRINONE
Olprinone(Loprinone)
1，2-Dihydro-5-imidazo[1，2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile
3-phenylmethoxy-1-cyclobutanecarboxylic acid ethyl ester
3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-
Olprinone USP/EP/BP
5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
106730-54-5
API