Tioxolone
- CAS No.
- 4991-65-5
- Chemical Name:
- Tioxolone
- Synonyms
- 6-HYDROXY-1,3-BENZOXATHIOL-2-ONE;Trocinate;ol110;Camyna;Stepin;Acnosan;Thiphen;tioxolon;thidoxol;ioxolone
- CBNumber:
- CB2696092
- Molecular Formula:
- C7H4O3S
- Molecular Weight:
- 168.17
- MDL Number:
- MFCD00005859
- MOL File:
- 4991-65-5.mol
- MSDS File:
- SDS
| Melting point | 158-160 °C(lit.) |
|---|---|
| Boiling point | 267.1°C (rough estimate) |
| Density | 1.4844 (rough estimate) |
| refractive index | 1.5151 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | 95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to yellow |
| form | A solid |
| pka | 8.14±0.20(Predicted) |
| Merck | 9456 |
| LogP | 1.770 (est) |
| CAS DataBase Reference | 4991-65-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | S0FAJ1R9CD |
| ATC code | D10AB03 |
| NIST Chemistry Reference | Tioxolone(4991-65-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DM2953750 | |||||||||
| HS Code | 2934999090 | |||||||||
| NFPA 704 |
|
Tioxolone price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 217077 | 6-Hydroxy-1,3-benzoxathiol-2-one ≥98% | 4991-65-5 | 50g | $166.2 | 2024-03-01 | Buy |
| Apolloscientific | OR937717 | 6-Hydroxy-1,3-benzoxathiol-2-one 95% | 4991-65-5 | 25g | $261 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 38111 | 6-Hydroxybenzo[d][1,3]oxathiol-2-one 95+% | 4991-65-5 | 10g | $350 | 2021-12-16 | Buy |
| AK Scientific | V1364 | Tioxolone | 4991-65-5 | 25g | $852 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0013052 | 6-HYDROXY-1,3-BENZOXATHIOL-2-ONE 95.00% | 4991-65-5 | 25G | $1270.5 | 2021-12-16 | Buy |
Tioxolone Chemical Properties,Uses,Production
Chemical Properties
light yellow to beige powder
Originator
Acnosan,Unia
Uses
6-Hydroxy-1,3-benzoxathiol-2-one was used in the synthesis of heterocycle-phosphor esters having potential antimicrobial activity.
Uses
antiseborrhoic
Definition
ChEBI: A 1,3-benzoxathiole having a hydroxy substituent at the 6-position.
Manufacturing Process
40 g potassium thiocyanate in 50 ml of water are added, while stirring at
room temperature, to a solution of 11 g of resorcinol and 50 g of crystallized
copper sulfate in 250 ml of water. The black cupric thiocyanate formed
becomes colorless after a short time, which indicates that the introduction of
thiocyanogen is terminated. The cuprous thiocyanate is removed by filtering
with suction and then washed with water; the filtrate is mixed with 50 ml of a
2 N sodium carbonate solution, whereby the imino-thiocarbonate of resorcinol
separates in the form of a colorless crystalline body. The yield amounts to 16
g. The new compound which melts at 149°C dissolves very easily in many
organic solvents and in mineral acids.
A 10% solution of the imino-thiocarbonate of resorcinol in 10% hydrochloric
acid is heated for 15 min on the steam bath. The 6-hydroxy-1,3-benzoxathiol-
2-one (thiocarbonate free from) nitrogen separates, on cooling, in the form of
fine crystals melting at 158°C.
Therapeutic Function
Antiseborreic, Antifungal, Keratolytic
General Description
Antimicrobial and cytostatic properties of 6-hydroxy-1,3-benzoxathiol-2-one has been investigated. Supramolecular structure of 6-hydroxy-1,3-benzoxathiol-2-one has been studied.
Tioxolone Preparation Products And Raw materials
Tioxolone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9116 | 58 |
| Supplier | Advantage |
|---|---|
| ATK CHEMICAL COMPANY LIMITED | 60 |
| Alchem Pharmtech,Inc. | 58 |
| CONIER CHEM AND PHARMA LIMITED | 58 |
| career henan chemical co | 58 |
| SIMAGCHEM CORP | 58 |
| TargetMol Chemicals Inc. | 58 |
| AFINE CHEMICALS LIMITED | 58 |
| Alfa Chemistry | 58 |
| InvivoChem | 58 |
| Shaanxi Didu New Materials Co. Ltd | 58 |
