Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Tandutinib

Tandutinib

Tandutinib Structure
Tandutinib structure
CAS No.
387867-13-2
Chemical Name:
Tandutinib
Synonyms
CS-309;MLN 518;CT 53518;NSC726292;Tandutinib;Unii-E1io3icj9a;CT53518; MLN518;Tandutinib(TINIBS);MLN518, Tandutinib;Tandutinib (MLN518)
CBNumber:
CB31011758
Molecular Formula:
C31H42N6O4
Molecular Weight:
562.7
MDL Number:
MFCD09954147
MOL File:
387867-13-2.mol
Last updated:2023-05-18 11:31:13
Request For Quotation

Tandutinib Properties

Melting point 177-178°C
Boiling point 769.5±60.0 °C(Predicted)
Density 1.213±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 13.39±0.70(Predicted)
color White to Off-White
CAS DataBase Reference 387867-13-2(CAS DataBase Reference)
NCI Dictionary of Cancer Terms CT53518; MLN518; tandutinib
FDA UNII E1IO3ICJ9A
NCI Drug Dictionary tandutinib

Tandutinib price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2672 Tandutinib hydrochloride ≥98% (HPLC) 387867-13-2 25MG $60.7 2024-03-01 Buy
Sigma-Aldrich SML2672 Tandutinib hydrochloride ≥98% (HPLC) 387867-13-2 100MG $98.4 2024-03-01 Buy
Cayman Chemical 12098 Tandutinib ≥95% 387867-13-2 25mg $56 2024-03-01 Buy
Cayman Chemical 12098 Tandutinib ≥95% 387867-13-2 50mg $93 2024-03-01 Buy
Cayman Chemical 12098 Tandutinib ≥95% 387867-13-2 100mg $140 2024-03-01 Buy
Product number Packaging Price Buy
SML2672 25MG $60.7 Buy
SML2672 100MG $98.4 Buy
12098 25mg $56 Buy
12098 50mg $93 Buy
12098 100mg $140 Buy

Tandutinib Chemical Properties,Uses,Production

Description

Tandutinib is a potent antagonist of platelet-derived growth factor receptor β (PDGFRβ), FLT3, and c-Kit (IC50 = 200, 220, and 170 nM, respectively). It less potently inhibits macrophage colony-stimulating factor 1 receptor (IC50 = 3.4 μM) and does not significantly inhibit other tyrosine or serine/threonine kinases. Tandutinib blocks the growth of cells expressing an internal tandem duplication within the juxtamembrane domain of the FLT3 receptor, found in some acute myelogenous leukemia cells. It also impairs the growth of colon cancer cells through its actions on the c-Kit receptor. Tandutinib reverses multidrug resistance in vitro by impairing the efflux activity of the multidrug resistance protein 7.

Chemical Properties

White Solid

Uses

An oral, small-molecule inhibitor of FLT3 for the treatment of AML (acute myelogenous leukemia) clinical trials in patients with AML and myelodysplastic syndrome, but displayed promising antileukemic activity (90% complete remissions) in a phase I/II trial in patients with newly diagnosed AML w hen administered in combination with cytarabine and daunorubicin.

Uses

An oral, small-molecule inhibitor of FLT3 for the treatment of AML (acute myelogenous leukemia) and other cancer indications. The drug exhibited limited activity as a single agent in phase I and II clinical trials in patients with AML and myelody

Uses

antipsoratic

Definition

ChEBI: An N-arylpiperazine that is piperazine in which the hydrogen attached to the nitrogen at position 1 is replaced by a 6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl group, while the hydrogen attached to the nitrogen at position 4 s replaced by a (p-isopropoxyphenyl)aminocarbonyl group. Tandutinib is an inhibitor of tyrosine kinases FLT3, PDGFR and KIT.

target

c-Kit

References

[1] kelly lm1, yu jc, boulton cl, apatira m, li j, sullivan cm, williams i, amaral sm, curley dp, duclos n, neuberg d, scarborough rm, pandey a, hollenbach s, abe k, lokker na, gilliland dg, giese na. ct53518, a novel selective flt3 antagonist for the treatment of acute myelogenous leukemia (aml). cancer cell. 2002 jun;1(5):421-32.

Tandutinib Preparation Products And Raw materials

Raw materials

Preparation Products

Tandutinib Suppliers

Global( 172)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Xiamen AmoyChem Co., Ltd 		+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
SIMAGCHEM CORP 		+86-13806087780 sale@simagchem.com China 17367 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23556 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29067 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Xiamen AmoyChem Co., Ltd 		58
Hubei xin bonus chemical co. LTD 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
SIMAGCHEM CORP 		58
TargetMol Chemicals Inc. 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Dideu Industries Group Limited 		58

View Lastest Price from Tandutinib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tandutinib pictures 2022-02-25 Tandutinib
387867-13-2
 US $2.00 / KG 1KG 98% 100KG Hong Kong Tiansheng New Material Trading Co., Ltd
Tandutinib pictures 2022-02-25 Tandutinib
387867-13-2
 US $2.00 / KG 1KG 99% 10kg Hong Kong Tiansheng New Material Trading Co., Ltd
Tandutinib USP/EP/BP pictures 2021-07-07 Tandutinib USP/EP/BP
387867-13-2
 US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
  • Tandutinib pictures
  • Tandutinib
    387867-13-2
  • US $2.00 / KG
  • 98%
  • Hong Kong Tiansheng New Material Trading Co., Ltd
  • Tandutinib pictures
  • Tandutinib
    387867-13-2
  • US $2.00 / KG
  • 99%
  • Hong Kong Tiansheng New Material Trading Co., Ltd

387867-13-2(Tandutinib)Related Search:

5-Hydroxytryptophan Quizartinib (AC220) Linifanib (ABT-869) Dasatinib Masitinib
PD 0332991 HCl Ibrutinib Bosutinib 6,7-DIMETHOXY-4-PIPERAZIN-1-YL-QUINAZOLINE Tandutinib

1of2

Tandutinib 1-Piperazinecarboxamide, 4-(6-methoxy-7-(3-(1-piperidinyl)propoxy)-4-quinazolinyl)-N-(4-(1-methylethoxy)phenyl)- 4-(6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl)piperazine-1-carboxylic acid (4-isopropoxyphenyl)amide Unii-E1io3icj9a Tandutinib(CT 53518) Tandutinib (MLN518) CT53518; MLN518 Tandutinib(TINIBS) (4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide 4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide 4-[6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-1-piperazinecarboxamide CT 53518 MLN 518 Tandutinib for research N-(4-isopropoxyphenyl)-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-yl)piperazine-1-carboxamide NSC726292 (4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide Tandutinib(MLN518) 4-[6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-Methylethoxy)phenyl]- N-(4-Isopropoxyphenyl)-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-yl)piperazine-1- MLN518; CT53518; MLN 518; CT 53518; MLN-518; CT-53518; Tandutinib (CT53518, MLN518) CS-309 Tandutinib（MLN518, CT53518） Tandutinib USP/EP/BP Tandutinib (MLN518, CT53518, NSC-726292) 4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(... MLN518, Tandutinib Tandutinib CT53518 MLN518 CT-53518 MLN-518 387867-13-2 C31H42N6O4 C27H31Br2ClN4O2 Inhibitors ZUBRIN API Intermediates & Fine Chemicals Pharmaceuticals Tyrosine Kinase Inhibitors