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Anastrozole

Indications and Usage Clinical Research
Anastrozole
Anastrozole
CAS No.
120511-73-1
Chemical Name:
Anastrozole
Synonyms
zd;MDPT;ZD-1033;ARIMIDEX;Anastrol;Astrozole;Anatrozole;Anastrozol;ICI-D-1033;ANASTROZOLE
CBNumber:
CB3121715
Molecular Formula:
C17H19N5
Formula Weight:
293.37
MOL File:
120511-73-1.mol

Anastrozole Properties

Melting point:
81-82°C
storage temp. 
Store at RT
solubility 
DMSO: soluble40mg/mL
InChIKey
YBBLVLTVTVSKRW-UHFFFAOYSA-N
CAS DataBase Reference
120511-73-1(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22-61-60
Safety Statements  26-37/39
RIDADR  3249
RTECS  CZ1465000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29339980
Hazardous Substances Data 120511-73-1(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
Precautionary statements:
P201 Obtain special instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Anastrozole price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A2736 Anastrozole ≥98% (HPLC) 120511-73-1 10mg $76.9 2017-11-08 Buy
Sigma-Aldrich 1034807 Anastrozole 120511-73-1 200mg $560 2017-11-08 Buy
TCI Chemical A2370 Anastrozole >98.0%(HPLC)(T) 120511-73-1 100mg $180 2017-12-01 Buy
Cayman Chemical 11987 Anastrozole ≥98% 120511-73-1 50mg $99 2017-11-08 Buy
Cayman Chemical 11987 Anastrozole ≥98% 120511-73-1 10mg $45 2017-11-08 Buy

Anastrozole Chemical Properties,Uses,Production

Indications and Usage

Anastrozole is a potent selective triazole aromatase inhibitor that inhibits the aromatase that cytochrome P-450 is dependent on to prevent the biosynthesis of estrogen. Estrogen is the main stimulating factor for breast cancer cell growth. This drug’s half maximal inhibitory concentration (IC50) value to human placental aromatase is 15nmol/L. Compared to the traditional drug tamoxifen, Anastrozole can comprehensively and effectively lower the risks of breast cancer recurrence and metastasis, thus extending patients’ disease-free survival.
Anastrozole is suitable for treating postmenopausal advanced breast cancer patients, especially postmenopausal advanced breast cancer patients who experienced recurrence following hormone assisted therapy.

Clinical Research

A series of clinical trials compared the effects of third generation aromatase inhibitor Anastrozole with those of tamoxifen. The trial was a global multicenter trial and includes 381 centers in 21 countries. Since 1996, there have been 9366 patients who have participated, and the follow-up time is 100 months. 25.8% of patients in the Anastrozole group experienced recurrence, while 29.9% of patients in the tamoxifen group did. Thus, Anastrozole’s recurrence rate was 4.1% lower than that of tamoxifen, and its risk of distant metastasis was lower as well. Anastrozole is also safer than tamoxifen.

Chemical Properties

Crystalline Solid

Uses

antiseptic, spermaticide

Uses

An aromatase inhibitor. Used as an antineoplastic.

Definition

ChEBI: A 1,2,4-triazole compound having a 3,5-bis(2-cyano-2-propyl)benzyl group at the 1-position.

Biological Activity

Potent and highly selective aromatase (CYP19) inhibitor (IC 50 = 15nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo . Orally active.

Anastrozole Preparation Products And Raw materials

Raw materials

Preparation Products


Anastrozole Suppliers

Global( 274)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3229 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 660 60
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
027-83214668 bruce@xrdchem.cn CHINA 509 55
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19953 60
Sichuan Tuskwei Import and Export Trade Co., Ltd.
86-311-83306736
86-311-83306736 sales@tuskwei.com CHINA 300 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20810 55
Mainchem Co., Ltd.
0592-6210733
0592-6210733 sales@mainchem.com CHINA 3270 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales2@fine-chemtech.com CHINA 893 55
Hangzhou Rongda Pharm & Chem Co., Ltd. +86 (571) 28281880
+86 (571) 28281887 sales@rdpharm.com China 78 60
Heta Pharm & Chem CO.,Ltd. +86-571-88298691 89905385
+86-571-87353175 sales@hetapharm.com;sales2@hetapharm.com China 72 60

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