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Anastrozole

Indications and Usage Clinical Research

CAS No. 120511-73-1
Chemical Name: Anastrozole
Synonyms: zd;ZD-1033;ARIMIDEX;Anastrol;Astrozole;Anatrozole;Anastrozol;ICI-D-1033;ANASTROZOLE;ANASTRAZOLE
CBNumber: CB3121715
Molecular Formula: C17H19N5
Formula Weight: 293.37
MOL File: 120511-73-1.mol
Anastrozole Property
Melting point : 81-82°C
storage temp. : Store at RT
solubility : DMSO: soluble40mg/mL
CAS DataBase Reference: 120511-73-1(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : Xi,Xn
Risk Statements : 36/37/38-22-61-60
Safety Statements : 26-37/39
RIDADR : 3249
RTECS : CZ1465000
HazardClass : 6.1(b)
PackingGroup : III
HS Code : 29339980
Hazardous Substances Data: 120511-73-1(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
Precautionary statements:
P201 Obtain special instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Anastrozole Chemical Properties,Usage,Production

Indications and Usage
Anastrozole is a potent selective triazole aromatase inhibitor that inhibits the aromatase that cytochrome P-450 is dependent on to prevent the biosynthesis of estrogen. Estrogen is the main stimulating factor for breast cancer cell growth. This drug’s half maximal inhibitory concentration (IC50) value to human placental aromatase is 15nmol/L. Compared to the traditional drug tamoxifen, Anastrozole can comprehensively and effectively lower the risks of breast cancer recurrence and metastasis, thus extending patients’ disease-free survival.
Anastrozole is suitable for treating postmenopausal advanced breast cancer patients, especially postmenopausal advanced breast cancer patients who experienced recurrence following hormone assisted therapy.
Clinical Research
A series of clinical trials compared the effects of third generation aromatase inhibitor Anastrozole with those of tamoxifen. The trial was a global multicenter trial and includes 381 centers in 21 countries. Since 1996, there have been 9366 patients who have participated, and the follow-up time is 100 months. 25.8% of patients in the Anastrozole group experienced recurrence, while 29.9% of patients in the tamoxifen group did. Thus, Anastrozole’s recurrence rate was 4.1% lower than that of tamoxifen, and its risk of distant metastasis was lower as well. Anastrozole is also safer than tamoxifen.
Chemical Properties
Crystalline Solid
Uses
antiseptic, spermaticide
Uses
An aromatase inhibitor. Used as an antineoplastic.
Definition
ChEBI: A 1,2,4-triazole compound having a 3,5-bis(2-cyano-2-propyl)benzyl group at the 1-position.
Biological Activity
Potent and highly selective aromatase (CYP19) inhibitor (IC 50 = 15nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo . Orally active.
Anastrozole Preparation Products And Raw materials
Raw materials
5-Methyl-1,3-benzenediacetonitrile Sodium hydride N-Bromosuccinimide 1,2,4-Triazole N,N-Dimethylformamide Carbon tetrachloride 1,2,4-Triazolylsodium Ethyl acetate PETROLEUM ETHER Iodomethane
Preparation Products
Anastrozole Suppliers      Global( 258)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd. +86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19953 60
Shenzhen Sendi Biotechnology Co.Ltd. 0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3230 55
Hangzhou Rongda Pharm & Chem Co., Ltd. +86 (571) 28281880
+86 (571) 28281887 sales@rdpharm.com China 73 60
Suzhou Unite pharmTech Co., Ltd , +86-013222993784 +86-512-82177310
+86-512-82177310 +86-512-62575043 sales@unite-pharm.com China 85 56
Heta Pharm & Chem CO.,Ltd. +86-571-88298691 89905385
+86-571-87353175 sales@hetapharm.com;sales2@hetapharm.com China 72 60
Jinan Aery Pharmaceutical Co,.Ltd 86-0531-81263406
86-0531-58591634 sales@aerpharm.com;andmchem@gmail.com China 68 55
Beijing Huikang Boyuan Chemical Tech Co., Ltd 010-68862197
010-68882204 bjhkby@126.com China 87 61
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96831 76
INTATRADE GmbH +49 3493/605464
+49 3493/605470 sales@intatrade.de Germany 3589 66
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15950 69
 
120511-73-1(Anastrozole)Related Search:
ANASTROZOLE INTERMEDIATE ANASTROZOLE-D12 Anastrozole&Int. 3,5-Bis(2-cyanoprop-2-yl)benzyl bromide 1,3-Phenylenediacetonitrile 3-Methylbenzyl cyanide 2,2'-(5-Methyl-1,3-phenylene)diacetonitrile ( For Anastrozole ) 3,5-DI-TERT-BUTYL-BENZYLAMINE 2,2-(5-methyl-1,3-phenylene)di(2-methylpropiononitrile (intermediate of anastrozole) 3,5-Dimethylphenylacetonitrile PROPIONITRILE-3,3,3-D3 Anastrozole p-Nitrophenylacetonitrile Diphenylacetonitrile 4-BROMO-2,2-DIPHENYLBUTYRONITRILE 5-Methyl-1H-benzotriazole Tolyltriazole Benzeneacetonitrile
ICI-D-1033 ARIMIDEX 1-[3,5-DI-(1-METHYL-1-CYANO)-ETHYL]-BENZYL-1,2,4-TRIAZOLE 120511-73-1 ANASTRAZOLE ANASTROZOLE tetramethyl-5-(1h-1,2,4-triazol-1ylmethyl) 1,3-benzenediacetionitrile ZD-1033 1,3-benzenediacetonitrile,alpha,alpha,alpha’,alpha’-tetramethyl-5-(1h-1,2,4-t riazol-1-ylmethyl)- Anastrozol Anatrozole C17H19N5 ZD-1033, ICI-D-1033, Arimidex 120511-12-1 2-[3-(2-Cyano-2-propyl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropiononitrile 1,3-benzenediacetonitrile, alpha,alpha,alpha',alpha'-tetramethyl- 5-(1h-1,2,4-triazol-1-ylmethyl)- zd C15H23N5 Active Pharmaceutical Ingredients 1120511-73-1 Antineoplastic 120511-73-11 a1,a1,a3,a3-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile Anastrol All Inhibitors anti-neoplastic Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Anastrozole α,α,α’,α'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile 2-[3-(2-Cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile α1,α1,α3,α3-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile Anastrozole(AriMidex) Anastrozole (200 mg) 2-[3-(1-cyano-1-Methylethyl)-5-(1H-1,2,4-triazol-1-ylMethyl)phenyl]-2-Methylpropanenitrile Anastrozole IMpurity B Anastrolozole alpha,alpha,alpha',alpha'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile API Anastrozole USP 2,2'-(5-((1H-1,2,4-Triazol-1-yl)Methyl)-1,3-phenylene)bis(2-Methylpropanenitrile) 3-tetraMethyl-5-(1H-1,2,4-triazol-1-ylMethyl)- 2"-[5-(1H-1 3-Phenylene]bis(2-methyl-propiononitrile 4-Triazol-1-ylmethyl)-1 a,a,a′,a′-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile 120511-73-1 Anastrozole, >=98% Letrozole:4,4,-(dinitrilephenyl)methyl 1-yl -1,2,4-triazol Astrozole
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