ChemicalBook Chinese  Japanese  Germany

ChemicalBook >> CAS DataBase List >> Anastrozole

Anastrozole

letrozole and anastrozole Chemical properties Anastrozole would become the standard of adjuvant therapy for breast cancer Anastrozole dosage Uses Precautions Major Side Effects Production methods References

CAS No.120511-73-1
Chemical Name:Anastrozole
Synonyms:zd;ZD-1033;ARIMIDEX;Anastrol;Anatrozole;Anastrozol;ICI-D-1033;ANASTROZOLE;ANASTRAZOLE;2"-[5-(1H-1
CBNumber:CB3121715
Molecular Formula:C17H19N5
Formula Weight:293.37
MOL File:120511-73-1.mol
Anastrozole Property
Melting point : 81-82°C
storage temp. : Store at RT
CAS DataBase Reference: 120511-73-1(CAS DataBase Reference)
Safety
Hazard Codes : Xi,Xn
Risk Statements : 36/37/38-22-61-60
Safety Statements : 26-37/39
RIDADR : 3249
HazardClass : 6.1(b)
PackingGroup : III
HS Code : 29339980
Hazardous Substances Data: 120511-73-1(Hazardous Substances Data)

Anastrozole Chemical Properties,Usage,Production

letrozole and anastrozole
Anastrozole is an inhibitor for the triazole aromatase with a strong selectivity. It can inhibits aromatase which is prerequisite for the synthesis of pigment cells P-450 thereby blocking the biosynthesis of estrogens, and the estrogen is the essential part of the growth of breast cancer cells. The 50% inhibitory concentration (IC50) value of anastrozole to placental aromatase is 15nmol/L.
Letrozole is used for the treatment of advanced breast cancer of postmenopausal women.It mainly applied to the second-line treatment after the failure of the anti-estrogen treatment.
Chemical properties
It can be crystallized from ethyl acetate – cyclohexane, the melting point is 81~82℃.
Anastrozole would become the standard of adjuvant therapy for breast cancer
One the world's largest and longest research of clinical trials about using the aromatase inhibitors in adjuvant therapy for breast cancer shows the latest results that: Compared with conventional drugs like tamoxifen, anastrozole can reduce the risk of the recurrence and metastasis of breast cancer effectively and comprehensively,prolong disease-free survival; even the patient has completed the treatment for 4 years, the protective effect of anastrozole remains sustainable. Professor Xu B,H, who is the deputy director of Medical Oncology of Chinese Academy of Medical Sciences Cancer Hospital, recently proposed that, this indicate the anastrozole will become the standard scheme of adjuvant endocrine therapy for breast cancer.
According to Xu B,H, the commonly used traditional endocrine drugs after breast cancer surgery is tamoxifen. Tamoxifen has many side effects, such as the endometrial cancer and thromboembolic etc. This clinical trial compared the effect of the tamoxifen with third-generation aromatase inhibitors-anastrozole. There are 21 countries and 381 test centers participate in this  global multi-center clinical trial. They test 9366 patients for 100 months since 1996. The result shows that 25.8% of patients at anastrozole group recurred, and the recurrence rate for the patients at tamoxifen group was 29.9%, so anastrozole reduces the recurrence rate of 4.1% compare with the tamoxifen and also decrease the risk of distant metastasis at the same time. For security ,anastrozole is also superior to tamoxifen.
Anastrozole dosage
You take anastrozole as a tablet, once a day. Try to take it at the same time each day. Swallow the tablet whole with a drink of water. You can take it before, with, or after food.
It is very important that you take tablets according to the instructions your doctor or pharmacist gives you. You should take the right dose, not more or less. It is a long term treatment and you usually need to take it for several years. Never stop taking a cancer drug without talking to your specialist first.
If you accidentally take more anastrozole than you should, let your doctor know straight away.
If you forget a dose, continue with the next dose as normal. Don't take an extra dose to make up for the missed one.
Uses
(1) It is the third-generation’s aromatase inhibitors, used for the treatment of advanced breast cancer of postmenopausal patients.
(2) Its used to cure the breast cancer.
(3) Anastrozole is the third-generation’s aromatase inhibitors, used for the treatment of advanced breast cancer of postmenopausal patients. It is an inhibitor for the triazole aromatase with a strong selectivity. It can inhibits aromatase which is prerequisite for the synthesis of pigment cells P-450 thereby blocking the biosynthesis of estrogens, and the estrogen is the essential part of the growth of breast cancer cells. Its used to cure the breast cancer, particularly suitable for postmenopausal women with advanced breast cancer who recrudescent after hormone adjuvant therapy.
Precautions

  • you are allergic to any ingredient in anastrozole
  • you have not gone through menopause
  •  you are pregnant or may become pregnant
  • the patient is a man or a child
  • you are taking estrogen-containing products (eg, certain birth control pills or hormone replacement therapies) or tamoxifen
Major Side Effects
  • Blurred vision
  • chest pain or discomfort
  • dizziness
  • headache
  • nervousness
  • pounding in the ears
  • shortness of breath
  • slow or fast heartbeat
  • swelling of the feet or lower legs
Production methods
Compound (I) (has the methods of preparation) brominated by the N-bromosuccinimide (NBS) .Treating the product (II) with triazole sodium can obtain the final product.
References
https://www.drugs.com/cdi/anastrozole.html
http://www.cancerresearchuk.org/about-cancer/cancers-in-general/treatment/cancer-drugs/anastrozole
Chemical Properties
Crystalline Solid
Usage
antiseptic, spermaticide
Usage
An aromatase inhibitor. Used as an antineoplastic.
Definition
ChEBI: A 1,2,4-triazole compound having a 3,5-bis(2-cyano-2-propyl)benzyl group at the 1-position.
Biological Activity
Potent and highly selective aromatase (CYP19) inhibitor (IC 50 = 15nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo . Orally active.
Anastrozole Preparation Products And Raw materials
Raw materials
5-Methyl-1,3-benzenediacetonitrile Sodium hydride N-Bromosuccinimide 1,2,4-Triazole N,N-Dimethylformamide Carbon tetrachloride 1,2,4-Triazolylsodium Ethyl acetate PETROLEUM ETHER Iodomethane
Preparation Products
Anastrozole Suppliers      Global( 251)Suppliers     
SupplierTelFaxEmailCountryProdListAdvantage
Hangzhou Rongda Pharm & Chem Co., Ltd. +86 (571) 28281880+86 (571) 28281887sales@rdpharm.comCHINA 73 60
Suzhou Unite pharmTech Co., Ltd , +86-013222993784 +86-512-82177310+86-512-82177310 +86-512-62575043sales@unite-pharm.comCHINA 99 56
Heta Pharm & Chem CO.,Ltd. +86-571-88298691 89905385+86-571-87353175sales@hetapharm.com;sales2@hetapharm.comCHINA 72 60
Beijing Huikang Boyuan Chemical Tech Co., Ltd 010-68862197010-68882204bjhkby@126.comCHINA 87 61
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833+86-10-82849933jkinfo@jkchemical.com;market6@jkchemical.comCHINA 96832 76
INTATRADE GmbH +49 3493/605464+49 3493/605470sales@intatrade.deGERMANY 3589 66
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:1893055203786-21-503281093bsc@sina.comCHINA 15950 69
Arden pharmaceutical &chemical Co., Ltd +86-(0)533-3595900 13793319233+86-(0)533-3595900info@chems.com.cnCHINA 670 61
Chembest Research Laboratories Limited +86(0)21-20908456+86(0)21-58180499sales@biochembest.com; market@biochembest.comCHINA 6024 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 180086-571-85864795sales@capotchem.comCHINA 18279 66
 
120511-73-1(Anastrozole)Related Search:
ANASTROZOLE INTERMEDIATE ANASTROZOLE-D12 Anastrozole&Int. 3,5-Bis(2-cyanoprop-2-yl)benzyl bromide 1,3-Phenylenediacetonitrile 3-Methylbenzyl cyanide 2,2'-(5-Methyl-1,3-phenylene)diacetonitrile ( For Anastrozole ) 3,5-DI-TERT-BUTYL-BENZYLAMINE 2,2-(5-methyl-1,3-phenylene)di(2-methylpropiononitrile (intermediate of anastrozole) 3,5-Dimethylphenylacetonitrile PROPIONITRILE-3,3,3-D3 Anastrozole p-Nitrophenylacetonitrile Diphenylacetonitrile 4-BROMO-2,2-DIPHENYLBUTYRONITRILE 5-Methyl-1H-benzotriazole Tolyltriazole Benzeneacetonitrile
ICI-D-1033 ARIMIDEX 1-[3,5-DI-(1-METHYL-1-CYANO)-ETHYL]-BENZYL-1,2,4-TRIAZOLE 120511-73-1 ANASTRAZOLE ANASTROZOLE tetramethyl-5-(1h-1,2,4-triazol-1ylmethyl) 1,3-benzenediacetionitrile ZD-1033 1,3-benzenediacetonitrile,alpha,alpha,alpha’,alpha’-tetramethyl-5-(1h-1,2,4-t riazol-1-ylmethyl)- Anastrozol Anatrozole C17H19N5 ZD-1033, ICI-D-1033, Arimidex 120511-12-1 2-[3-(2-Cyano-2-propyl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropiononitrile 1,3-benzenediacetonitrile, alpha,alpha,alpha',alpha'-tetramethyl- 5-(1h-1,2,4-triazol-1-ylmethyl)- zd C15H23N5 Active Pharmaceutical Ingredients 1120511-73-1 Antineoplastic 120511-73-11 a1,a1,a3,a3-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile Anastrol All Inhibitors anti-neoplastic Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Anastrozole α,α,α’,α'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile 2-[3-(2-Cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile α1,α1,α3,α3-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile Anastrozole(AriMidex) Anastrozole (200 mg) 2-[3-(1-cyano-1-Methylethyl)-5-(1H-1,2,4-triazol-1-ylMethyl)phenyl]-2-Methylpropanenitrile Anastrozole IMpurity B Anastrolozole alpha,alpha,alpha',alpha'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile API Anastrozole USP 2,2'-(5-((1H-1,2,4-Triazol-1-yl)Methyl)-1,3-phenylene)bis(2-Methylpropanenitrile) 3-tetraMethyl-5-(1H-1,2,4-triazol-1-ylMethyl)- 2"-[5-(1H-1 3-Phenylene]bis(2-methyl-propiononitrile 4-Triazol-1-ylmethyl)-1 a,a,a′,a′-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile 120511-73-1 Anastrozole, >=98% Letrozole:4,4,-(dinitrilephenyl)methyl 1-yl -1,2,4-triazol
Copyright 2016 © ChemicalBook. All rights reserved