ChemicalBook >> CAS DataBase List >>(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
- CAS No.
- 20445-33-4
- Chemical Name:
- (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
- Synonyms
- (+)-MTPA-CL;R(-)-MTPA-CL;(S)-(+)-MTPA-CL;(2S)-2-Methoxy-2-;(+)-MOSHER'S CHLORIDE;(S)-(+)-MTPA-Chloride;(S)-(+)-Acid chloride;MOSHER'S ACID CHLORIDE;(+)-MOSHER'S ACID CHLORIDE;(S)-(+)-Mosher'sacidchloride
- CBNumber:
- CB3170768
- Molecular Formula:
- C10H8ClF3O2
- Molecular Weight:
- 252.62
- MDL Number:
- MFCD00067105
- MOL File:
- 20445-33-4.mol
- MSDS File:
- SDS
Last updated:2023-07-28 17:44:41
| Boiling point | 213-214 °C(lit.) |
|---|---|
| alpha | D24 +129.0± 0.2° (c = 5.17 in CCl4) |
| Density | 1.35 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 194 °F |
| storage temp. | -20°C |
| form | Liquid |
| color | Clear colorless to light yellow |
| Specific Gravity | 1.353 |
| optical activity | [α]20/D +137±2°, c = 6.4% in carbon tetrachloride |
| Water Solubility | Slightly miscible with water. |
| Sensitive | Moisture Sensitive |
| Merck | 14,6280 |
| BRN | 3591564 |
| CAS DataBase Reference | 20445-33-4(CAS DataBase Reference) |
| FDA UNII | 472VA70UL4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-43 | |||||||||
| Safety Statements | 26-36/37/39-45-27 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| Hazard Note | Corrosive/Freeze | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29189900 | |||||||||
| NFPA 704 |
|
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 65365 | (S)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride for chiral derivatization, LiChropur?, ≥99.0% | 20445-33-4 | 100mg | $166 | 2024-03-01 | Buy |
| Sigma-Aldrich | 65365 | (S)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride for chiral derivatization, LiChropur?, ≥99.0% | 20445-33-4 | 500mg | $641 | 2024-03-01 | Buy |
| Sigma-Aldrich | 369675 | (S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride 99% | 20445-33-4 | 50mg | $70.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | 369675 | (S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride 99% | 20445-33-4 | 250mg | $168 | 2024-03-01 | Buy |
| TCI Chemical | M1103 | (S)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines] >98.0%(GC) | 20445-33-4 | 100mg | $67 | 2024-03-01 | Buy |
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Chemical Properties,Uses,Production
Chemical Properties
clear colorless to light yellow liquid
Uses
Used in the synthesis of natural products and pheromones.
Uses
(S)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride is used in the preparation of natural products and pheromones. It is also employed as a derivatization enantiomeric purity reagent used for the determination of enantiomeric purity of alcohol and amines by gas chromatography.
Uses
Resolution of enantiomers primarily of alcohols and amines.
General Description
(S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride is commonly used as a derivatizing agent in Mosher ester analysis and Mosher amide analysis, which are NMR-based methods for determining the absolute configuration of the chiral carbon center in secondary alcohols and amines, respectively.
Purification Methods
The most likely impurity is the free acid due to hydrolysis and should be checked by IR. If free from acid, then distil, taking care to keep moisture out of the apparatus. Otherwise add SOCl2 and reflux for 5hours and distil it. Note that shorter reflux times result in a higher boiling fraction (b 130-155o/1mm) which has been identified as the anhydride. [Dale et al. J Org Chem 34 2543 1969, for enantiomeric purity see Dale & Mosher J Am Chem Soc 97 512 1973.]
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Suppliers
Global( 127)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | sales@allfluoro.com | China | 5791 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3465 | 58 |
| VladaChem GmbH | +49-7246-3082843 | info@vladachem.de | Germany | 1860 | 58 |
View Lastest Price from (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-07-29 | (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
20445-33-4
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-03-25 | (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
20445-33-4
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Guanlang Biotechnology Co., Ltd. | |
 |
2021-07-02 | (S)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetyl chloride 99%
20445-33-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
20445-33-4
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
20445-33-4
- US $0.00-0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
-
- (S)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetyl chloride 99%
20445-33-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
20445-33-4((S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE)Related Search:
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
1-Pentanol
Phenylacetyl chloride
3,3,3-TRIFLUOROPROPIONYL CHLORIDE
(R)-2-CHLORO-1-PHENYLETHANOL
3-CHLORO-1,1,1-TRIFLUOROPROPANE
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE,(+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
4-FLUORO-3-(TRIFLUOROMETHYL)ANISOLE
1of4
(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
(S)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, 98+%
(S)-(+)-MTPA-Cl, Moshers acid chloride
(S)-(+)-^a-Methoxy-^a-(trifluoromethyl)phenylacetyl chloride, 98+%
(S)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride,99%
(R)-(-)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
(R)-(-)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)BENZENEACETYLCHLORIDE
R(-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID CHLORIDE
(R)-(-)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
(R)-(-)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYL ACETYL CHLORIDE
(R)-(+)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
(+)-MOSHER'S ACID CHLORIDE
(S)-(+)-ɑ-Methoxy-ɑ-(trifluoromethyl)phenylacetyl chloride, 98+%
(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]
(S)-(+)-α-Methoxy-α-(trifluoromethyl)benzeneacetylchloride
(+)-MTPA-Cl
(S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride,(S)-(+)-MTPA-Cl, Mosher’s acid chloride
(2S)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoyl chloride 99% (99%ee)
(S)-(+)-MTPACl, (S)-(+)-Mosher's acid chloride, (2S)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropionyl chloride
(S)-(+)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetyl chloride, 99% 1GR
(+)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetyl Chloride (ca. 18% in DichloroMethane, ca. 1.0Mol/L) [for DeterMination of the optical purity of Alcohols and AMines]
(+)-Mosher's Acid Chloride
(+)-MTPA-Cl
(S)-3,3,3-Trifluoro-2-Methoxy-2-phenylpropanoyl chloride
(+)-α-Methoxy-α-(trifluoroMethyl)phenylacetyl Chloride [for DeterMination of the optical purity of Alcohols and AMines]
(+)-α-Methoxy-α-(trifluoroMethyl)phenylacetyl Chloride (ca. 18% in DichloroMethane, ca. 1.0Mol/L) [for DeterMination of the optical purity of Alcohols and AMines]
(2S)-2-Methoxy-2-
Benzeneacetyl chloride, α-Methoxy-α-(trifluoroMethyl)-, (S)-
Hydratropoyl chloride, β,β,β-trifluoro-α-Methoxy-, (+)- (8CI)
(2S)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoyl chloride 99%
(S)-3,3,3-Trifluoro-2-methoxy-2-phenylpropionyl chloride
S-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid chloride
MOSHER'S ACID CHLORIDE
(+)-MOSHER'S CHLORIDE
(+)-MTPA-CL
R(-)-MTPA-CL
(S)-(+)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYL ACETYL CHLORIDE
(S)-(+)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
(S)-(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)BENZENEACETYLCHLORIDE
(S)-(-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
(S)-(+)-MTPA-CL
(S)-(+)-A-METHOXY-A-(TRIFLUOROMETHYL)-PH ENYLACETYL CHLORIDE, 99%(98% EE/GLC)
(R)-(+)-Methoxy-trifluoromethylphenylacetyl chloride
(S)-(+)-Mosher'sacidchloride
(S)-(+)-MTPA-Chloride
(S)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetylchloride(ee)
(s)-(+)-à-methoxy-à-(trifluoromethyl)phenylacetyl chloride
(S)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetyl chloride 99% (99%ee)
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE 99%
(S)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetyl chloride (99%ee)
(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetylChloride[forDeterminationoftheopticalpurityofAlcoholsandAmines]
(s)-(+)-alphaMethoxy-alpha(three fluoroMethyl)phenyl acetyl chloride
(S)-2-Methoxy-2-(trifluoromethyl)phenylacetyl chloride
(2S)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoylchloride99%
(S)-(+)-α-Methoxy-α-(trifluoromethyl)benzeneacetylchloride
(S)-(+)-Acid chloride
(S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride
(2S)-2-Methoxy-2-trifluoromethylphenylacetyl chloride
(S)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]