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Ziconotide Polyacetate

Ziconotide Polyacetate Structure
Ziconotide Polyacetate structure
CAS No.
107452-89-1
Chemical Name:
Ziconotide Polyacetate
Synonyms
snx111;Ziconotide;ω-conotoxin mviia;OMEGA-CGTX MVII A;o-Conotoxin MVIIA;Zicontide Acetate;ω-Conotoxin MVIIA;ZICONOTIDE ACETATE;SNX-111, Ziconotide;OMEGA-CONOTOXIN MVIIA
CBNumber:
CB3190092
Molecular Formula:
C102H172N36O32S7
Molecular Weight:
2639.13
MDL Number:
MFCD00145036
MOL File:
107452-89-1.mol
MSDS File:
SDS
Last updated:2024-03-29 18:52:01
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Ziconotide Polyacetate Properties

Density 1.60±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO (Slightly, Sonicated), Methanol (Slightly)
form Solid
color White to Off-White
InChIKey BPKIMPVREBSLAJ-QTBYCLKRSA-N
NCI Dictionary of Cancer Terms SNX 111; ziconotide
FDA UNII 7I64C51O16
NCI Drug Dictionary ziconotide
ATC code N02BG08

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301+H331
Precautionary statements  P261-P304+P340+P312-P403+P233
RIDADR  3172
WGK Germany  3
HazardClass  6.1(b)
PackingGroup  III

Ziconotide Polyacetate price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C1182 ω-Conotoxin MVIIA ≥95% (HPLC) 107452-89-1 0.1mg $260 2022-05-15 Buy
Sigma-Aldrich C1182 ω-Conotoxin MVIIA ≥95% (HPLC) 107452-89-1 0.5mg $938 2022-05-15 Buy
TRC Z385000 ZiconotidePolyacetate 107452-89-1 2.5mg $3390 2021-12-16 Buy
Biosynth Carbosynth FC110295 Omega-Conotoxin MVIIA 107452-89-1 500ug $600 2021-12-16 Buy
Product number Packaging Price Buy
C1182 0.1mg $260 Buy
C1182 0.5mg $938 Buy
Z385000 2.5mg $3390 Buy
FC110295 500ug $600 Buy

Ziconotide Polyacetate Chemical Properties,Uses,Production

Description

ω-conotoxin MVIIA, also knwn as Ziconotide acetate, is a peptide consisting of 25 amino acid.  It is a disulfide-bridged polypeptide from the venom of the sea snail Conusmagus that binds to neuronal N-type calcium channels. It forms a compact folded structure, presenting a loop between Cys8 and Cys15 that contains a set of residues critical for its binding. Both ω-conotoxins GVIA and MVIIA could bind to neuronal N-type calcium channels. ω-conotoxin GVIA is rich in hydroxyl groups while ω-conotoxin MVIIA contains a large number of positively charged side chains[1-2].

Uses

Ziconotide acetate (ω-Conotoxin MVIIA), the peptide toxin of the Conus magus (cone snail) is a selective antagonist of N-type voltage sensitive calcium channels (VSCC). As a most well-known identified conotoxin so far, it has been used as a effective drug to treat intractable chronic pain in cancer and ADIS patients[2]. Blocks neurotransmitter release by preventing depolarization-induced calcium influx. Used as a ligand for binding studies of voltage sensitive calcium channels. Analgesic; neuroprotective.

brand name

Prialt (Elan).

General Description

ω-Conotoxin MVIIA functions as a selective inhibitor of N-type voltage-sensitive calcium channels (VSCCs). It has analgesic and neuroprotective effects. ω-Conotoxin MVIIA is used to treat neuropathic pain.

Biochem/physiol Actions

Neuronal N-type Ca2+ channel blocker in mammalian and amphibian brain; blocks release of GABA and glutamate at neuronal synapses.

References

[1] Wang R, et al. Development of an ic-ELISA and immunochromatographic strip based on IgG antibody for detection of ω-conotoxin MVIIA. Journal of Hazardous Materials, 2019; 378: 120510.
[2] Zhou Y, et al. A Chemoenzymatic Approach To Produce a Cyclic Analogue of the Analgesic Drug MVIIA (Ziconotide). Angew. Chem. Int. Ed., 2023; 62: e202302812.

Ziconotide Polyacetate Preparation Products And Raw materials

Raw materials

Preparation Products

Ziconotide Polyacetate Suppliers

Global( 199)Suppliers
Supplier Tel Email Country ProdList Advantage
Hantai Biomedical Group Co. LTD
+8618819265912 id002@cnhantide.com China 37 58
henan kanbei chemical co.,ltd 		+undefined-86-1523780-4566 +undefined15237804566 henankanbeichemical@163.com China 511 58
Henan Tengmao Chemical Technology Co. LTD 		+8615238638457 salesvip2@hntmhg.com China 415 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2503 58
Wuhan Haorong Biotechnology Co.,ltd 		+8618565342920 sales@chembj.net China 269 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11013 58
Nantong Guangyuan Chemicl Co,Ltd 		+undefined17712220823 admin@guyunchem.com China 616 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7845 58
Alpha Biopharmaceuticals Co., Ltd 		+86-411-39042497 +8613921981412 sales@alphabiopharm.com China 886 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Supplier Advantage
Hantai Biomedical Group Co. LTD
58
henan kanbei chemical co.,ltd 		58
Henan Tengmao Chemical Technology Co. LTD 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Wuhan Haorong Biotechnology Co.,ltd 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Nantong Guangyuan Chemicl Co,Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Alpha Biopharmaceuticals Co., Ltd 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58

View Lastest Price from Ziconotide Polyacetate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ziconotide acetate pictures 2024-04-24 Ziconotide acetate
107452-89-1
 US $0.00-0.00 / kg 20kg 99% 200000 Wuhan Haorong Biotechnology Co.,Ltd
Ziconotide Polyacetate pictures 2024-03-29 Ziconotide Polyacetate
107452-89-1
 US $8.00-1.00 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
ω-Conotoxin MVIIA pictures 2024-03-08 ω-Conotoxin MVIIA
107452-89-1
 US $10.00 / kg 1kg 99% 1000kg Nantong Guangyuan Chemicl Co,Ltd

107452-89-1(Ziconotide Polyacetate)Related Search:

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H-PHE-BETA-ALA-OH H-TYR-BETA-ALA-OH H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2

1of4

OMEGA-CONOTOXIN MVIIA OMEGA-CGTX MVII A ZICONOTIDE ACETATE snx111 H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2 H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2 (DISULFIDE BRIDGE: 1-16, 8-20, AND 15-25) CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2 CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (DISULFIDE BRIDGE: 1-16,8-20, AND 15-25) ω-conotoxin mviia omega-conopeptide MVIIA SNX-111, Ziconotide omega-Conopeptide MVIIA (Conus) H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2, disulfid bridges 1-16/8-20/15-25 REF DUPL: H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2, disulfid bridges 1-16/8-20/15-25 Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys -Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2(Disulfide,Cys1-Cys16, Cys8-Cys20,Cys15-Cys25) Ziconotide [USAN:INN] CONOTOXIN MVII A (Omega-) o-Conotoxin MVIIA Ziconotide Zicontide Acetate L-Cysteinamide, L-cysteinyl-L-lysylglycyl-L-lysylglycyl-L-alanyl-L-lysyl-L-cysteinyl-L-seryl-L-arginyl-L-leucyl-L-methionyl-L-tyrosyl-L-α-aspartyl-L-cysteinyl-L-cysteinyl-L-threonylglycyl-L-seryl-L-cysteinyl-L-arginyl-L-serylglycyl-L-lysyl-, cyclic (1→16),(8→20),(15→25)-tris(disulfide) Ziconotide acetate USP/EP/BP ω-Conotoxin MVIIA Ziconotide Polyacetate 107452-89-1 107425-89-1 914451-03-8 C102H172N36O32S7 C102H172N36O32S7C2H4O2 Cell Biology Calcium Channel Modulators Peptide Toxins Ion Channels Voltage-gated Ion Channels Cell Signaling and Neuroscience BioChemical Peptide 107452-89-1