DESIPRAMINE
- CAS No.
- 50-47-5
- Chemical Name:
- DESIPRAMINE
- Synonyms
- DMI 50475;Pentofran;Sertofran;Desipramin;Pertrofane;esipramine;DESIPRAMINE;Desimpramine;Desimipramine;Norimipramine
- CBNumber:
- CB3257775
- Molecular Formula:
- C18H22N2
- Molecular Weight:
- 266.38
- MDL Number:
- MFCD00242884
- MOL File:
- 50-47-5.mol
| Melting point | 212°C |
|---|---|
| Boiling point | bp0.02 172-174° |
| Density | 0.9934 (rough estimate) |
| refractive index | 1.5200 (estimate) |
| pka | pKa 10.21(-)(H2O t=20) (Uncertain) |
| form | powder |
| color | white |
| FDA UNII | TG537D343B |
| ATC code | N06AA01 |
| EPA Substance Registry System | Desipramine (50-47-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H370-H336-H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P403+P233-P405-P501-P260-P264-P270-P307+P311-P321-P405-P501 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22 |
| Safety Statements | 36 |
| WGK Germany | 3 |
DESIPRAMINE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | D3219-92B | Desipramine | 50-47-5 | 500ul | $319 | 2021-12-16 | Buy |
| Usbiological | 226913 | Desipramine | 50-47-5 | 500ul | $360 | 2021-12-16 | Buy |
| Usbiological | 226914 | Desipramine | 50-47-5 | 500ul | $360 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009063 | DESIPRAMINE 95.00% | 50-47-5 | 0.5G | $529 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | D33925 | Desipramine-d4HCl | 50-47-5 | 1mg | $670 | 2021-12-16 | Buy |
DESIPRAMINE Chemical Properties,Uses,Production
Originator
Pertofran,Geigy,UK,1963
Uses
Desipramine is used for depression of various etiology and in particular for endogenous depression.
Uses
Antidepressant.
Definition
ChEBI: A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Manufacturing Process
Oxidative coupling of o-nitrotoluene gives 4,4'-dinitrodibenzyl which is reduced with hydrogen to the diamine. The diamine is pyrolyzed to give dihydrobenzazepine. This is reacted with N-(3-chloropropyl)-Nmethylbenzamine to give N-benzyldesipramine. This is debenzylated by reductive cleavage and then reacted with HCl.
brand name
Norpramin (Sanofi Aventis); Pertofrane (Sanofi Aventis).
Therapeutic Function
Psychostimulant
Mechanism of action
Its antidepressant effect results from increases in the level of NE in CNS synapses, and long-term administration causes a downregulation of α1-adrenoceptors and desensitization of presynaptic α2-receptors, equilibrating the noradrenergic system and, thus, correcting the dysregulated output of depressed patients. The SSRIs do not produce this effect. Desipramine also downregulates the NET, but not the 5-SERT . Substantial loss of NE transporter–binding sites takes 15 days to occur and is accompanied by a marked reduction of NET function in vivo. Desipramine has weak effects on 5-HT reuptake.
Synthesis
Desipramine, 10,11-dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f] azepine (7.1.13), differs from imipramine in that it contains only one methyl group on the nitrogen atom of the propylamine side chain. The suggested methods of desipramine synthesis are very simple, and the difference lies only in the manner in which the secondary methylamine group is introduced into the structure of the drug.
The first way of synthesis is by the alkylation of 10,11-dihydro-5H-dibenz[b,f]azepine using 1-bromo-3-chloropropane in the presence of sodium amide into a chloro derivative (7.1.12) and the subsequent reaction of this with methylamine, giving desipramine (7.1.13) [18–20].
Finally, a second way of synthesis is from imipramine (7.1.1), which undergoes demethylation by successive reaction with ethyl chloroformate, giving 5-[3-(N-carbethoxy-N-methyl)aminopropyl]-10,11-dihydro-5H-dibenz[b,f]azepine (7.1.15), the alkaline hydrolysis of which leads to desipramine (7.1.13) [23,24].
Metabolism
Desipramine is a dihydrodibenzazepine secondary amine TCA that also is the active metabolite of imipramine. Desipramine appears to have a bioavailability comparable to the other secondary TCAs. Desipramine is distributed into milk in concentrations similar to those present at steady state in maternal plasma. This drug is metabolized primarily by CYP2D6 to its 2-hydroxy metabolite and by CYP1A2 and CYP2C19 to its N-demethylated (primary amine) metabolite . Desipramine exhibits a greater potency and selectivity for the NET than the other secondary TCAs do.
DESIPRAMINE Preparation Products And Raw materials
DESIPRAMINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9116 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| Shanxi Tihondan Pharmaceutical Technology Co., Ltd | +8618235132063 | sales@tihondan.com | China | 3716 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
View Lastest Price from DESIPRAMINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-27 | DESIPRAMINE USP/EP/BP
50-47-5
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- DESIPRAMINE USP/EP/BP
50-47-5
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
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