DESIPRAMINE HYDROCHLORIDE

DESIPRAMINE HYDROCHLORIDE Properties

Melting point	214-2160C
Flash point	11 °C
storage temp.	2-8°C
solubility	H₂O: 50 mg/mL
form	powder
color	white to off-white
Water Solubility	Soluble to 100 mM in water
FDA UNII	1Y58DO4MY1
NCI Drug Dictionary	desipramine hydrochloride

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H302-H315-H317-H319-H334-H335
Precautionary statements	P280-P301+P312+P330-P302+P352-P305+P351+P338
Hazard Codes	Xn,T,F
Risk Statements	22-36/37/38-42/43-48/23/24/25-23/24/25-11-39/23/24/25
Safety Statements	7-16-36/37-45-26-24-22
RIDADR	UN 1230 3/PG 2
WGK Germany	3
RTECS	HO0525000
HS Code	2933996100
Toxicity	LD50 in mice, rats (mg/kg): 500, 385 orally; 94, 48 i.p.; 420, 183 s.c. (Eriksoo, Rohte)

DESIPRAMINE HYDROCHLORIDE price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D3900	Desipramine hydrochloride ≥98% (TLC), powder	58-28-6	1g	$55.1	2024-03-01	Buy
Sigma-Aldrich	D-906	Desipramine hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?	58-28-6	1mL	$27.7	2024-03-01	Buy
Sigma-Aldrich	BP931	Desipramine hydrochloride British Pharmacopoeia (BP) Reference Standard	58-28-6	100MG	$257	2024-03-01	Buy
Sigma-Aldrich	1172006	Desipramine hydrochloride United States Pharmacopeia (USP) Reference Standard	58-28-6	125mg	$358	2024-03-01	Buy
Sigma-Aldrich	D3900	Desipramine hydrochloride ≥98% (TLC), powder	58-28-6	5g	$194	2024-03-01	Buy

Product number	Packaging	Price	Buy
D3900	1g	$55.1	Buy
D-906	1mL	$27.7	Buy
BP931	100MG	$257	Buy
1172006	125mg	$358	Buy
D3900	5g	$194	Buy

DESIPRAMINE HYDROCHLORIDE Chemical Properties,Uses,Production

Chemical Properties

White To Off-White Solid

Originator

Pertofran,Geigy,UK,1963

Uses

Tricyclic antidepresant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.

Uses

Desipramine hydrochloride has been used:

to prevent norepinephrine neuron degeneration and to maximize uptake into DA neurons
to protect unselective damage to the?noradrenergic system
as a norepinephrine re-uptake inhibitor to treat rats for lesioning

Uses

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.

Definition

ChEBI: The hydrochloride salt of desipramine.

Manufacturing Process

Oxidative coupling of o-nitrotoluene gives 4,4'-dinitrodibenzyl which is reduced with hydrogen to the diamine. The diamine is pyrolyzed to give dihydrobenzazepine. This is reacted with N-(3-chloropropyl)-Nmethylbenzamine to give N-benzyldesipramine. This is debenzylated by reductive cleavage and then reacted with HCl.

brand name

Norpramin (Sanofi Aventis); Pertofrane (Sanofi Aventis).

Therapeutic Function

Psychostimulant

General Description

The structure and salient properties of desipramine hydrochloride,10,11-dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine monohydrochloride, 5-(3-methylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride(Norpramin, Pertofrane), are discussed under the heading,Imipramine. Among tricyclics, desipramine would be consideredwhen few anticholinergic effects or a low level of sedationare important. It is a SNERI.

Biological Activity

Tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (K i values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).

Biochem/physiol Actions

Desipramine is used to treat depression. It is also used to manage enuresis in children. Desipramine helps to eliminate the pain triggered by diabetic neuropathy.

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: decreased urine volume, sodium level changes, chlorine level changes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO, and HCI.

storage

Desiccate at +4°C

DESIPRAMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Hydrogen 2-Nitrotoluene

Preparation Products

DESIPRAMINE HYDROCHLORIDE Suppliers

Global( 139)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29016	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9923	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	50000	58

Supplier	Advantage
Standardpharm Co. Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Hefei Hirisun Pharmatech Co., Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
LEAP CHEM CO., LTD.	58
GIHI CHEMICALS CO.,LIMITED	58

View Lastest Price from DESIPRAMINE HYDROCHLORIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-27	DESIPRAMINE HYDROCHLORIDE USP/EP/BP 58-28-6	US $1.10 / g	1g	99.9%	100 Tons min	Dideu Industries Group Limited
	2020-01-03	DESIPRAMINE HYDROCHLORIDE 58-28-6	US $1.00 / KG	1KG	95-99%	1ton	Career Henan Chemical Co

DESIPRAMINE HYDROCHLORIDE USP/EP/BP
58-28-6
US $1.10 / g
99.9%
Dideu Industries Group Limited

DESIPRAMINE HYDROCHLORIDE
58-28-6
US $1.00 / KG
95-99%
Career Henan Chemical Co

DESIPRAMINE HYDROCHLORIDE Spectrum

DESIPRAMINE HYDROCHLORIDE(58-28-6)¹HNMR

58-28-6(DESIPRAMINE HYDROCHLORIDE)Related Search:

Clomipramine LOFEPRAMINE HYDROCHLORIDE LOFEPRAMINE carpipramine dihydrochloride Imipramine hydrochloride

IMIPRAMINE-D3 HYDROCHLORIDE 98 ATOM % D DESIPRAMINE HYDROCHLORIDE Clomipramine hydrochloride MOSAPRAMINE DESIPRAMINE

1'-[3-(3-chloro-10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl][1,4'-bipiperidine]-4'-carboxamide dihydrochloride N-DESMETHYLCLOMIPRAMINE HYDROCHLORIDE IMIPRAMINE-2,4,6,8-D4 HCL IMIPRAMINE HYDROCHLORIDE, [N-METHYL-3H] 8-hydroxyclomipramine

NORCLOMIPRAMINE DESMETHYLIMIPRAMINE HCL, [BENZENE RING-10,11-3H]- DESIPRAMINE HCL (D4)

1of4

Desipramine solution hydrochloride RMI-9384A 10-11-Dihydro-N-methyl-5H-dibenz(Z)[b,f]azepine-5-propanaminehydrochloride Desipramine Hydrochloride (125 mg) Desipramine Hydrochloride (125 mg)I0E2831.000mg/mg(dr) 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine monohydrochloride 5-[3-(Methylamino)propyl]-5H-dibenz[b,f]azepine hydrochloride 10,11-dihydro-5-(3-(methylamino)propyl)-5h-dibenz(b,f)azepinehydrochloride demethylimipraminehydrochloride desmethylimipraminehydrochloride dmihydrochloride ex4355 f)azepine,10,11-dihydro-5-(3-(methylamino)propyl)-5h-dibenz(hydrochlorid f)azepine,10,11-dihydro-5-(3-(methylamino)propyl)-5h-dibenz(monohydrochlor g35020 imipraminedemethylhydrochloride jb8181 Petylyl 5H-Dibenzb,fazepine-5-propanamine, 10,11-dihydro-N-methyl-, monohydrochloride DESIPRAMINEHYDROCHLORIDE,USP 3-(5,6-dihydrobenzo[b][1 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methyl-propan-1-amine 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methyl-propan-1-amine hydrochloride 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine hydrochloride 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methyl-amine Desimipramine-hydrochloride DesipraMine Monohydrochloride Desipramine hydrochloride solution [3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]methylamine hydrochloride n-(gamma-methylaminopropyl)iminodibenzylhydrochloride norpramin nsc-114901 pertofran pertofrane DESIPRAMINE HCL DESIPRAMINE HYDROCHLORIDE 10,11-DIHYDRO-N-METHYL-5-H-DIBENZ-[B,F]AZEPINE HYDROCHLORIDE DESIPRAMINE HYDROCHLORIDE METHANOL*SOLUT ION 10,11-Dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine Nortimil Desipramine hydrochloride Solution, 1000ppm Desipramine hydrochloride Solution, 100ppm Desipramine hydrochloride CRS (3-{2-azatricyclo[9.4.0.0,?]pentadeca-1(11),3(8),4,6 ,12,14-hexaen-2-yl}propyl)(methyl)amine hydrochloride 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine hydrochloride esipraminehydrochloride DESIPRAMINE HYDROCHLORIDE USP/EP/BP Desipramine oxalate salt Desipramine Hydrochloride (1.0 mg/mL in Methanol) Desipramine HydrochlorideQ: What is Desipramine Hydrochloride Q: What is the CAS Number of Desipramine Hydrochloride Q: What is the storage condition of Desipramine Hydrochloride Q: What are the applications of Desipramine Hydrochloride Imipramine Hydrochloride ImpurityⅡ:DesipraMine hydrochloride Desipramine Hydrochloride (1172006) Imipramine EP Impurity A Imipramine Hydrochloride ImpurityⅡ:DesipraMine hydrochloride Imipramine Impurity 1（Imipramine EP Impurity A） Imipramine Hydrochloride Impurity A as Hydrochloride Imipramine Hydrochloride EP Impurity A as Hydrochloride