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SQ 22,536

SQ 22,536 structure

CAS No.: 17318-31-9

Chemical Name:: SQ 22,536

Synonyms: Ax 100;CS-2551;Nsc 53339;9-THF-Ade;SQ 22,536;SQ 22536;SQ-22536;SQ22,536/Inhibitor;SQ22536 (NSC-53339);9-(Tetrahydrofuran-2-yl);Tetrahydrofuryl-9-adenine

CBNumber:: CB3289950

Molecular Formula:: C9H11N5O

Molecular Weight:: 205.22

MDL Number:: MFCD00210216

MOL File:: 17318-31-9.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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SQ 22,536 Properties

Melting point	160-161℃
Boiling point	474.8±55.0 °C(Predicted)
Density	1.70±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	H₂O: 21 mg/mL
form	solid
pka	3.82±0.10(Predicted)
color	white to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HS Code

2934.99.9001

NFPA 704

	0
2		0

SQ 22,536 price More Price(41)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S153	SQ 22,536 ≥97% (HPLC), powder	17318-31-9	5mg	$220	2024-03-01	Buy
Sigma-Aldrich	568500	SQ 22536 Cell-permeable adenylate cyclase inhibitor.	17318-31-9	5mg	$187	2024-03-01	Buy
TCI Chemical	Q0105	SQ 22536	17318-31-9	10MG	$156	2024-03-01	Buy
TCI Chemical	Q0105	SQ 22536	17318-31-9	50MG	$560	2024-03-01	Buy
Alfa Aesar	J67455	SQ 22536 95%	17318-31-9	5mg	$136	2023-06-20	Buy

Product number	Packaging	Price	Buy
S153	5mg	$220	Buy
568500	5mg	$187	Buy
Q0105	10MG	$156	Buy
Q0105	50MG	$560	Buy
J67455	5mg	$136	Buy

SQ 22,536 Chemical Properties,Uses,Production

Description

SQ 22,536 is an inhibitor of adenylyl cyclase with an IC₅₀ value of 13 μM for inhibition of prostaglandin E₁-stimulated increase in cAMP in intact platelets. It has been used to evaluate adenylyl cyclase activity during iloprost-induced vasorelaxation of isolated pulmonary veins or aorta in several research paradigms, inhibiting cAMP elevation at concentrations of 100-300 μM without effecting relaxation.

Uses

SQ 22,536 was used to study the role of adenylate cyclase in differentiation of PC12 cells and in gap junctional intercellular communication in breast cancer cells.

Definition

ChEBI: A nucleoside analogue that is adenine in which the nitrogen at position 9 has been substituted by a tetrahydrofuran-2-yl group. It is an adenylate cyclase inhibitor.

Biological Activity

Inhibitor of adenylyl cyclase (IC 50 = 1.4 μ M). Inhibits PGE 1 -stimulated increases in cAMP levels in intact human platelets.

Biochem/physiol Actions

SQ 22,536 is an effective inhibitor of not only basal but also prosptaglandin E1-activated adenylate cyclase activities in platelets.1 It reverses hyperalgesia contralaterally and ipsilaterally when injected intramuscularly in rats.2

storage

Store at +4°C

SQ 22,536 Preparation Products And Raw materials

Raw materials

Preparation Products

SQ 22,536 Suppliers

Global( 120)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19994	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nanjing Doge Biomedical Technology Co., Ltd	+86-25-58227606 +86-15305155328	sales@dogechemical.com	China	4128	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Alchem Pharmtech,Inc.	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
Labnetwork lnc.	58
InvivoChem	58
Nanjing Doge Biomedical Technology Co., Ltd	58
LEAP CHEM CO., LTD.	58

SQ 22,536 Spectrum

SQ 22,536(17318-31-9)¹HNMR

17318-31-9(SQ 22,536)Related Search:

Cyclic AMP 5'-IODO-5'-DEOXYADENOSINE ADENOSINE-2':3'-CYCLIC MONOPHOSPHATE, SODIUM SALT 2'-Deoxyadenosine monohydrate 8-BROMOADENOSINE

3'-ADENYLIC ACID N6-ISOPENTENYLADENOSINE-D6 2',3'-O-Isopropylideneadenosine 5'-Tosyladenosine 2-Chloroadenosine

2'-Deoxyadenosine 5'-phosphate Vidarabine Adenosine 5'-monophosphate monohydrate Bucladesine sodium N6-BENZYLADENOSINE

N6-Benzoyl-2'-deoxyadenosine 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE 5'-ACETYL-2',3'-ISOPROPYLIDENEADENOSINE

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9-(2-tetrahydrofuryl)adenine SQ 22,536 ADENYLATE CYCLASE INH 9-(Tetrahydro-2-furynal)-9H-purin-6-amine SQ22,536/Inhibitor 9-(Tetrahydro-2-furanyl)-9H-purin-6-amine, 9-THF-Ade 6-Amino-9-[(tetrahydrofuran)-2-yl]-9H-purine 9-(Tetrahydrofuran-2-yl)-9H-purine-6-amine 6-Amino-9-(tetrahydro-2-furyl)-9H-purine 9-(Tetrahydrofuryl)adenine 9H-Purin-6-amine, 9-(tetrahydro-2-furanyl)- (9ci) Adenine, 9-(tetrahydro-2-furanyl)- (8ci) Adenine, 9-(tetrahydro-2-furyl)- Ax 100 Nsc 53339 9-(Tetrahydrofuran-2-yl)-9H-purin-6-aMine 9H-Purin-6-aMine, 9-(tetrahydro-2-furanyl)- 9-THF-Ade 9-(Tetrahydrofuran-2-yl) SQ 22,536 9-(oxolan-2-yl)-9H-purin-6-amine 9-(TETRAHYDRO-2-FURANYL)-9H-PURIN-6-AMINE 9-(TETRAHYDRO-2-FURANYL)-9H-PURINE-6-AMINE 9-(TETRAHYDRO-2'-FURYL)ADENINE 9-(oxolan-2-yl)purin-6-amine 9-THF-ADE;9-(TETRAHYDROFURAN-2-YL)-9H-PURIN-6-AMINE SQ 22536 - CAS 17318-31-9 - Calbiochem CS-2551 SQ 22536;SQ-22536 Tetrahydrofuryl-9-adenine SQ22536 (NSC-53339) 9-(Tetrahydro-furan-2-yl)-9H-purin-6-ylamine 17318-31-9 C9H22N5O C9H11N5O G Proteins and Cyclic Nucleotides Cyclic Nucleotide Metabolism Adenylyl Cyclase Inhibitors BioChemical Cell Biology Cell Signaling and Neuroscience