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L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE

L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE structure

CAS No.: 1421-65-4

Chemical Name:: L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE

Synonyms: Nsc295453;Melevodopa;Levodopa Impurity 10;LevoMet Hydrochloride;Dopamine, methyl ester;L-DOPA Methyl Ester HCl;methyldopa hydrochloride;Melevodopa Hydrochloride;H-TYR(3-HYDROXY)-OME HCL;METHYL L-DOPA HYDROCHLORIDE

CBNumber:: CB3398894

Molecular Formula:: C10H14ClNO4

Molecular Weight:: 247.68

MDL Number:: MFCD00038958

MOL File:: 1421-65-4.mol

Last updated:2024-01-22 14:59:28

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L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE Properties

Melting point	174-175℃
alpha	+9.0° to +11.0° (20°C, 589nm) (C=2 in methanol)
storage temp.	-20°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	solid
color	white
InChI	InChI=1/C10H13NO4.ClH/c1-15-10(14)7(11)4-6-2-3-8(12)9(13)5-6;/h2-3,5,7,12-13H,4,11H2,1H3;1H/t7-;/s3
InChIKey	WFGNJLMSYIJWII-WMASNCOMNA-N
SMILES	C1(=CC=C(O)C(O)=C1)C[C@H](N)C(=O)OC.Cl \|&1:9,r\|
FDA UNII	JFU1A8866V
ATC code	N04BA04

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319-H335-H315-H302

Precautionary statements

P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362

WGK Germany

NFPA 704

	0
2		0

L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D1507	L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride solid	1421-65-4	1g	$206	2024-03-01	Buy
Sigma-Aldrich	D1507	L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride solid	1421-65-4	5g	$599	2024-03-01	Buy
Cayman Chemical	16149	L-DOPA methyl ester (hydrochloride) ≥98%	1421-65-4	1g	$167	2024-03-01	Buy
Cayman Chemical	16149	L-DOPA methyl ester (hydrochloride) ≥98%	1421-65-4	5g	$387	2024-03-01	Buy
Sigma-Aldrich	D1507	L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride solid	1421-65-4	500mg	$157	2024-03-01	Buy

Product number	Packaging	Price	Buy
D1507	1g	$206	Buy
D1507	5g	$599	Buy
16149	1g	$167	Buy
16149	5g	$387	Buy
D1507	500mg	$157	Buy

L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE Chemical Properties,Uses,Production

Description

L-DOPA (Item No. 13248) is a metabolic precursor of dopamine that is capable of crossing the blood brain barrier to act as a dopamine D₁ receptor agonist. It is produced from L-tyrosine by trysosine hydroxylase. In the brain, L-DOPA is converted to dopamine by the enzyme aromatic L-amino acid decarboxylase. It is conventionally used to increase dopamine concentrations in the brain as a treatment for Parkinson’s disease and stroke recovery. L-DOPA methyl ester is a neutral derivative of L-DOPA formulated for increased solubility compared to the parent compound.

Chemical Properties

White Solid

Uses

L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride has been used:

in treating 6-hydroxydopamine induced lesions mice serotonin neurons
in tyrosinase activity in B16F10 skin melanoma cells
to test its neuroprotective effect in mesencephalic neurons

Uses

Precursor to L-DOPA that crosses the blood-brain barrier; antiparkinsonian agent.

Uses

Selective Dopamine D1 receptor agonist.

Biochem/physiol Actions

L-3,4-Dihydroxyphenylalanine methyl ester is a precursor to?L-DOPA that crosses the blood-brain barrier. Antiparkinsonian agent L-DOPA methyl ester elicits antitumor functionality in leukemia and melanoma.

in vitro

l-dopa methyl ester is a neutral derivative of l-dopa formulated for increased solubility compared to the parent compound. l-dopa is a metabolic precursor of dopamine that is capable of crossing the blood brain barrier to act as a dopamine d1 receptor agonist [1].

in vivo

on intraperitoneal or subcutaneous administration to mice l-dopa methyl ester was found to be equivalent to l-dopa in reversing reserpine-induced akinesia and producing contraversive circling behaviour in rats. on oral administration the methyl ester was even more active. the administration of l-dopa or the methyl ester had equivalent changes of metabolite levels in striatal and mesolimbic dopamine, homovanillic acid, as well as 3,4-dihydroxyphenylacetic acid [2].

storage

-20°C

References

[1] berends, h. i.,nijlant, j.m.m.,movig, k.l.l., et al. the clinical use of drugs influencing neurotransmitters in the brain to promote motor recovery after stroke; a cochrane systematic review. european journal of physical and rehabilitation medicine 45(4), 621-630 (2009).
[2] cooper dr, marrel c, testa b, van de waterbeemd h, quinn n, jenner p, marsden cd. l-dopa methyl ester--a candidate for chronic systemic delivery of l-dopa in parkinson's disease. clin neuropharmacol. 1984;7(1):89-98.
[3] kleedorfer, b. ,lees, a.j. and stern, g.m. subcutaneous and sublingual levodopa methyl ester in parkinson’s disease. j.neurol.neurosurg.psychiatry 54(4), 373 (1991).

L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE synthesis

Synthesis of L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE from Levodopa

L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Diethyl ether Methanol Acetyl chloride Levodopa

Preparation Products

(S)-Methyl 2-((tert-butoxycarbonyl)aMino)-3-(3,4-dihydroxyphenyl)propanoate

L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE Suppliers

Global( 119)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Biopole Pharmatech Co., Ltd.	+8615151475053	biopole@163.com	China	37	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58

Supplier	Advantage
Biopole Pharmatech Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Standardpharm Co. Ltd.	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
BOC Sciences	58
Zhejiang J&C Biological Technology Co.,Limited	58

View Lastest Price from L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-02-06	L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE 1421-65-4	US $0.00 / g	1g	0.99	100kg	Biopole Pharmatech Co., Ltd.
	2019-07-06	L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE 1421-65-4	US $7.00 / kg	1kg	99%	100kg	Career Henan Chemical Co

L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE
1421-65-4
US $0.00 / g
0.99
Biopole Pharmatech Co., Ltd.

L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE
1421-65-4
US $7.00 / kg
99%
Career Henan Chemical Co

L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE Spectrum

L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE(1421-65-4)¹HNMR

1421-65-4(L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE)Related Search:

Methylphenidate hydrochloride METHYL (2S)-2-AMINO-3-(2,6-DICHLORO-3,4-DIMETHOXYPHENYL)PROPANOATE METHYL (2S)-2-AMINO-3-(3-CHLORO-4,5-DIMETHOXYPHENYL)PROPANOATE L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE Ethyl methyldopate hydrochloride

METHYL (2S)-2-AMINO-3-(2-CHLORO-3,4-DIMETHOXYPHENYL)PROPANOATE (S)-3,4-DIMETHOXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE METHYL (2S)-2-AMINO-3-(2,6-DICHLORO-3-HYDROXY-4-METHOXYPHENYL)PROPANOATE METHYL (2S)-2-AMINO-3-(2-CHLORO-3-HYDROXY-4-METHOXYPHENYL)PROPANOATE METHYL (2S)-2-AMINO-3-(3-CHLORO-4-HYDROXY-5-METHOXYPHENYL)PROPANOATE

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L-3,4-DIHYDROXYPHENYLALANINE METHYLESTER HYDROCHLO methyldopa hydrochloride 2-Amino-3-(3,4-dihydroxyphenyl)-propanoic acid methylester hydrochloride Dopamine, methyl ester L-Tyrosine, 3-hydroxy-, methyl ester, hydrochloride Nsc295453 L-DOPA Methyl Ester Hydrochloride 3,4-Dihydroxyphenyl-L-alanine methyl ester hydrochloride L-DOPA Me ester hydrochloride Levodopa methyl ester hydrochloride Methyl L-3-(3,4-dihydroxyphenyl)alaninate hydrochloride 3-(3,4-Dihydroxyphenyl)alanine Methyl Ester Hydrochloride 3-Hydroxy-L-tyrosine Methyl Ester Hydrochloride LevoMet Hydrochloride Melevodopa Hydrochloride Methyl 3-Hydroxy-L-tyrosine Hydrochloride Melevodopa (S)-Methyl 2-aMino-3-(3,4-dihydroxyphenyl)propanoate hydrochloride L-3,4-Dihydroxyphenylalanine Methyl ester hydrochloride -Methyl 2-amino-3-(3,4-dihydroxyphenyl) (S)-2-Amino-3-(3,4-dihydroxyphenyl)propanoic acid hydrochloride L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride Levodopa methyl ester hydrochloride L-DOPA Me ester hydrochloride L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE H-PHE(3,4-DI-HYDROXY)-OME HCL H-TYR(3-HYDROXY)-OME HCL 3,4-DIHYDROXY PHENYLALANINE METHYL ESTER HYDROCHLORIDE L-3, 4-Dihydroxyphenylalanine methyleester hydrochloride METHYL L-DOPA HYDROCHLORIDE L-3,4-dihydroxyphenylalanine methyl*ester hydroch methyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate hydrochloride 3,4-Dihydroxy-L-phenylalanine Methyl Ester Hydrochloride Levodopa Impurity 10 [(2S)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]azanium L-3,4-Dihydroxyphenylalanine methyl ester 3-hydroxy- L-Tyrosine methyl ester, hydrochloride (1:1) L-3,4-Dihydroxyphenylalanine Methyl Ester Hydrochloride,>95% L-Tyrosine, 3-hydroxy-, methyl ester, hydrochloride (1:1) 4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE TIANFUCHEM--1421-65-4--High purity L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE in stock L-DOPA Methyl Ester HCl 1421-65-4 C10H13NO4HCl C9H12ClNO4 Precursor to L-DOPA that crosses the blood-brain barrier; antiparkinsonian agent. Dopamine receptor Amino Acids & Derivatives Aromatics Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals