IDRA 21
- CAS No.
- 22503-72-6
- Chemical Name:
- IDRA 21
- Synonyms
- AMPAKINE;IDRA 21;IDRA 21,98%;S-18986 IDRA-21 AMPAKINE;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE;7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-...;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE S,S-DIOXIDE;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE;7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide;IDRA 21 Benzothiadiazine,7-chloro- 3,4-dihydro-3-methyl-,1,1- dioxide
- CBNumber:
- CB3468324
- Molecular Formula:
- C8H9ClN2O2S
- Molecular Weight:
- 232.69
- MDL Number:
- MFCD00270874
- MOL File:
- 22503-72-6.mol
- MSDS File:
- SDS
Melting point | 209 °C(Solv: acetic acid (64-19-7)) |
---|---|
Boiling point | 405.1±55.0 °C(Predicted) |
Density | 1.394±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
form | Solid |
pka | 9.78±0.40(Predicted) |
color | Off-White to Pale Yellow |
InChIKey | VZRNTCHTJRLTMU-UHFFFAOYSA-N |
FDA UNII | 689UW7PT68 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P280-P305+P351+P338 |
Safety Statements | 24/25 |
WGK Germany | 3 |
IDRA 21 price More Price(18)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | I5773 | IDRA 21 ≥98% | 22503-72-6 | 5mg | $210 | 2024-03-01 | Buy |
Tocris | 1219 | IDRA 21 ≥98%(HPLC) | 22503-72-6 | 10 | $183 | 2021-12-16 | Buy |
Tocris | 1219 | IDRA 21 ≥98%(HPLC) | 22503-72-6 | 50 | $770 | 2021-12-16 | Buy |
Usbiological | 255490 | IDRA 21 | 22503-72-6 | 10mg | $423 | 2021-12-16 | Buy |
TRC | I232500 | IDRA 21 | 22503-72-6 | 250mg | $1540 | 2021-12-16 | Buy |
IDRA 21 Chemical Properties,Uses,Production
Chemical Properties
white to off-white crystalline powder
Uses
IDRA-21 is a benzothiadiazine derivative and a positive allosteric modulator of glutamate AMPA receptors (1,2,3,4). It is able to increase excitatory synaptic strength by inhibiting AMPA receptor desensitization. IDRA 21 may exhibit therapeutic effects to ameliorate memory deficits in patients with cognitive impairments such as Alzheimer''s disease.
Uses
IDRA-21 inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 is more able to cross the blood-brain barrier than Cyclothiazide (C988960).
Definition
ChEBI: 7-chloro-3-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine 1,1-dioxide is a benzothiadiazine.
Biological Activity
Inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. More able to cross the blood-brain barrier than cyclothiazide (6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide ).
storage
Room temperature
IDRA 21 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hubei Langyou International Trading Co., Ltd | +86-18874586545 +86-18874586545 | linda@xrdchem.cn | China | 197 | 58 |
Wuhan Qiami Technology Co., Ltd | +8618062705058 | qiamichem@163.com | China | 148 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3878 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 2990 | 58 |
Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 | sales@chembj.net | China | 289 | 58 |
Hubei Chuyan Biopharmaceutical Co., Ltd | +1-027-87896938 +15172028168 | chuyan@chuyan.co | China | 24 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | sarah@tnjone.com | China | 1143 | 58 |
Hebei Mojin Biotechnology Co.,Ltd | +86-15028179902 | angelia@hbmojin.com | China | 1085 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21666 | 55 |
View Lastest Price from IDRA 21 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-25 | IDRA 21
22503-72-6
|
US $2900.00 / kg | 1kg | 99% min | 20 tons | Wuhan Senwayer Century Chemical Co.,Ltd | ||
2024-09-24 | IDRA21
22503-72-6
|
US $0.00 / kg | 1kg | 99.0%min. HPLC | 1000kg | HangZhou RunYan Pharma Technology Co.,LTD. | ||
2024-09-09 | IDRA 21
22503-72-6
|
US $0.00-0.00 / kg | 1kg | 99% | 500 | Wuhan Haorong Biotechnology Co.,Ltd |