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Fluconazole

Anti-fungal infection drug Chemical Properties Uses Production method
Fluconazole
Fluconazole
CAS No.
86386-73-4
Chemical Name:
Fluconazole
Synonyms
Elazor;Flusol;Zoltec;uk49858;diflucan;Difluean;Fluconal;FluMycon;Flunazol;Zoltec-d4
CBNumber:
CB3740293
Molecular Formula:
C13H12F2N6O
Formula Weight:
306.27
MOL File:
86386-73-4.mol

Fluconazole Properties

Melting point:
138-140°C
Density 
1.05
Flash point:
9℃
storage temp. 
−20°C
solubility 
DMSO: 5 mg/mL
form 
solid
Merck 
14,4122
CAS DataBase Reference
86386-73-4(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi,T,F
Risk Statements  22-36/37/38-20/21/22-39/23/24/25-23/24/25-11
Safety Statements  26-36-36/37/39-24/25-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
RTECS  XZ4810000
Hazardous Substances Data 86386-73-4(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Fluconazole price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F-031 Fluconazole solution 2.0mg/mL in methanol, ampule of 1mL, certified reference material 86386-73-4 031-1ml $61 2017-11-08 Buy
Sigma-Aldrich 1271700 Fluconazole United States Pharmacopeia (USP) Reference Standard 86386-73-4 200mg $348.4 2017-11-08 Buy
TCI Chemical F0677 Fluconazole >98.0%(GC)(T) 86386-73-4 1g $76 2017-12-01 Buy
TCI Chemical F0677 Fluconazole >98.0%(GC)(T) 86386-73-4 5g $235 2017-12-01 Buy
Alfa Aesar J62015 Fluconazole, 99% 86386-73-4 5g $320 2017-11-08 Buy

Fluconazole Chemical Properties,Uses,Production

Anti-fungal infection drug

Fluconazole is a novel kind triazole drug of anti-fungal infection which was first successfully developed by the American Pfizer with broad-spectrum anti-fungal effect. It belongs to a kind of systemic anti-fungal products and has high selectivity on the inhibitory effect of the fungal cytochrome P450-dependent enzyme. It is also a kind of potent and specific inhibitor for the fungi alcohol synthesis. Clinically it is mainly used for the treatment of vaginal candidiasis, thrush, atrophic oral candidiasis, fungal meningitis, pulmonary fungal infections, abdominal infections, urinary tract infections and skin fungi infection.
The main indication for fluconazole as follows:
1, systemic candidiasis: including candidemia, disseminated candidiasis and other forms of invasive Candida infections such as the peritoneum, endocardium, lungs and urinary tract infections. It can also be applied to patients of malignant tumors, special-care patients, patients who received radiotherapy, chemotherapy or immunosuppressive therapy as well as patients who are susceptible to other factors such as infection of Candida. It can also be used for prevention of the occurrence of candida infection for bone marrow transplant patients upon receiving cytotoxic drugs treatment or radiation treatment.
2, cryptococcosis: including cryptococcal meningitis and the cryptococcal infection in other parts (such as lung, skin). It can be applied to the patient of normal immune function, AIDS patients as well as patient of suppressed immune function due to organ transplant and other reasons. AIDS patients can administer this kind of drug for maintenance therapy and prevention of the relapse of cryptococcal disease.
3, mucosal candidiasis: including oropharyngeal, esophageal, non-invasive bronchial mucosal candidiasis, pulmonary candidiasis, Candida urine disease, mucocutaneous and chronic atrophic oral candidiasis. It can be applied to patients of both normal immune function and with impaired immune function.
4, fluconazole can be used as substitute of itraconazole for the treatment of blastomycosis and histoplasmosis.
5, it can be used for the treatment of acute or recurrent vaginal candidiasis.
6, for leukemia patients or patients of other malignant tumor who is susceptible to fungal infection upon undergoing chemotherapy or radiotherapy can apply it as means of preventive treatment.
7, it can be used for the treatment coccidioidomycosis.
8, it can be used for treatment of fungal skin disease including fungal skin infections such as body ringworm, tinea pedis, tinea versicolor, tinea capitis, onychomycosis and nail ringworm.
9, fluconazole can also be used for the treatment of skin chromomycosis.
In August 2002, the voriconazole (Pfizer) which enters in the United States is the further structural modified derivative of fluconazole with its antibacterial activity against pathogenic yeast being higher than fluconazole. Some case reports have demonstrated that the drug can successfully cure some rare fungal disease.

Chemical Properties

It appears as white to yellow-white crystalline powder and is slightly smelly with bitter taste. It is easily soluble in glacial acetic acid, methanol or ethanol, hardly soluble in water and almost insoluble in ether with the melting point being 137~141.6 ℃, or melting point being 138~140 ℃ (derived from ethyl acetate-hexane).
The above information is edited by the chemicalbook of Dai Xiongfeng.

Uses

This product belongs to fluorinated triazole antifungal drug with the antifungal spectrum being similar as ketoconazole but antifungal activity being higher than ketoconazole. Its mechanism of action is through inhibition of essential component of the fungal cell membrane, the ergosterol biosynthesis enzyme, blocking the ergosterol synthesis and breaking the integrity of the fungal cell wall, further inhibiting their growth and reproduction. The product has potent antifungal activity against Candida albicans, Microsporum canis, Cryptococcus neoformans, histoplasma capsulatum and epidermophyton.

Production method

Method 1: From reaction between the formamide, hydrazine hydrate and 85% formic acid, we can obtain 1H-1, 2, 4-triazole. From phenylenediamine, we can obtain difluorobenzene, which is further subject to bromination to generate 2, 4-difluoro-bromobenzene. Magnesium was dissolved in anhydrous diethyl ether and added drop wise of the diethyl ether solution of 2, 4-difluoro-bromobenzene under ultrasonic irradiation, followed by adding drop wise of the diethyl ether solution of 1, 3-dichloroacetone under ice-cooling condition. Stir at room temperature overnight. Add glacial acetic acid and water. The separated organic layer was dried and concentrated. Concentrate, triazole, potassium carbonate and PEG600 were dissolved in anhydrous ethyl acetate and were subject to reflux. Then filter, wash with water to neutralization and dryness. The solvent was distilled off and was further subject to cyclohexane-ethyl acetate (1: 1) recrystallization to obtain the fluconazole with the overall yield being 33.6% and the m.p. being 138.5-140 ℃.
The last step can also be carried out in propionitrile. 1, 3-dihalo (x = Br or Cl)-2-(2, 4-difluorophenyl)-2-propanol and 1H-1, 2, 4-triazol-propionitrile were put into propionitrile and subject to reflux under the catalysis of sodium hydroxide and PEG 600 phase transfer catalysis and obtain the fluconazole crude product. The crude product was dissolved in fatty alcohols (such as propanol, isopropanol or butanol, etc.), dissolved upon heating with a small amount of active carbon for decoloring and then cooled to give crystals which is the refined product of fluconazole with the melting point being 139~140 ℃.
Method 2:2: 2, 4-difluorophenyl methyl is reacted with the Grignard reagent of 1-chloromethyl-1, 2, 4-triazole, and hydrolyzed to obtain fluconazole.
Method 3: difluorophenyl is subject to bromination to generate 1-bromo-2, 4-difluorobenzene, and then further converted to Grignard reagent. The resulting Grignard reagent above is reacted with 1, 3-bis (1H-1, 2, 4-triazole group) acetone, followed by hydrolysis to give fluconazole.

Chemical Properties

White to Off-White Solid

Uses

Labelled Fluconazole (F421000). Used as an antifungal.

Uses

anticholinergic

Uses

For the treatment of fungal infections.

Uses

A triazole broad-spectrum antifungal agent.

Biological Activity

Triazole antifungal agent. Effective against Candida strains in vitro and in vivo .

Fluconazole Preparation Products And Raw materials

Raw materials

Preparation Products


Fluconazole Suppliers

Global( 298)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3229 55
Zhejiang Genebest Pharmaceutical Co.,Ltd. 86-571-63348198
86-571-63532801 genebest@163.com sales@genebest.com China 18 60
Suzhou Tianma Specialty Chemicals Co.,Ltd. +86-512-66319723
+86-512-68090175 marketing@tianmachem.com China 110 67
Hubei HongxinRuiYu Fine Chemical Co., Ltd. 15671591110
027-65526669 2545103399@qq.com China 177 58
Qufu Haida Tiancheng Biochemical Co., Ltd. +86 (537) 456-7186 / +86 15998733238
qfhdtc@126.com China 54 55
Wuhan Biocar Bio-Pharm Co., Ltd. 13343428090
86-027-87050469 sales@biocar.cn China 1551 50
Shenzhen Simeiquan Biotechnology Co. Ltd 18126413629 0755-23311925 QQ2355327053
0755-23311925 abel@ycgmp.com China 5255 58
Jinan Chenghui-shuangda Chemical Co.,Ltd. 0531-58897070
0531-58897032 market@jnchsd.com China 50 62
Taian Jiaye Biotechnology Co.Ltd 17753805872/0538-6309326
0538-6309326 jiaye@chembj.com China 3309 55

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