CHELERYTHRINE CHLORIDE
- CAS No.
- 3895-92-9
- Chemical Name:
- CHELERYTHRINE CHLORIDE
- Synonyms
- 1,2-diMethoxy-12-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-iuM chloride;TODDALIN;CHELERYTHRIN CL;Chelerythrine Cl;TODDALIN CHLORIDE;CHELERYTHRIN CHLORIDE;Chelerythrine cloride;Chelerythrine chloride;CHELERYTHRINE CHLORIDE(P);CHELERYTHRINE CHLORIDE(RG)
- CBNumber:
- CB3760820
- Molecular Formula:
- C21H18ClNO4
- Molecular Weight:
- 383.82
- MDL Number:
- MFCD00060717
- MOL File:
- 3895-92-9.mol
- MSDS File:
- SDS
| Melting point | 195-205 °C |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO: ≥10 mg/mL |
| form | powder |
| color | yellow to orange |
| Stability | Hygroscopic |
| InChIKey | WEEFNMFMNMASJY-UHFFFAOYSA-M |
| FDA UNII | 7IC98TZ0PZ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38-36/37 | |||||||||
| Safety Statements | 26-36-36/37 | |||||||||
| RIDADR | UN 1544PSN1 6.1 / PGII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | FL9200000 | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | mouse,LD50,intravenous,18500ug/kg (18.5mg/kg),Planta Medica. Vol. 43, Pg. 161, 1981. | |||||||||
| NFPA 704 |
|
CHELERYTHRINE CHLORIDE price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0002288 | Chelerythrine chloride CRS, European Pharmacopoeia (EP) Reference Standard | 3895-92-9 | Y0002288 | $152 | 2024-03-01 | Buy |
| Sigma-Aldrich | C2932 | Chelerythrine chloride ≥95% (TLC), powder | 3895-92-9 | 1mg | $66.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | 220285 | Chelerythrine Chloride Naturally-occurring alkaloid. | 3895-92-9 | 5mg | $187 | 2024-03-01 | Buy |
| Alfa Aesar | J62906 | Chelerythrine chloride, 99+% | 3895-92-9 | 5mg | $130.65 | 2024-03-01 | Buy |
| Alfa Aesar | J62906 | Chelerythrine chloride, 99+% | 3895-92-9 | 10mg | $200.65 | 2024-03-01 | Buy |
CHELERYTHRINE CHLORIDE Chemical Properties,Uses,Production
Description
Chelerythrine is a potent, cell permeable inhibitor of protein kinase C (IC50 = 660 nM) that does not inhibit tyrosine protein kinases, cAMP-
Chemical Properties
yellow to orange solid
Uses
Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.
General Description
Naturally occurring alkaloid. Cell-permeable, selective inhibitor of protein kinase C (IC50 = 660 nM). Acts on the catalytic domain irrespective of the attachment of the regulatory domain. Material is a competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.
Biochem/physiol Actions
Cell permeable: yes
storage
-20°C (desiccate)
References
1. j. m. herbert, j. m. augereau, j. gleye and j. p. maffrand, biochem biophys res commun 1990, 172, 993-999. 2. w. d. jarvis, a. j. turner, l. f. povirk, r. s. traylor and s. grant, cancer res 1994, 54, 1707-1714. 3. j. vrba, p. dolezel, j. vicar, m. modriansky and j. ulrichova, toxicol in vitro 2008, 22, 1008-1017. 4. m. vogler, k. weber, d. dinsdale, i. schmitz, k. schulze-osthoff, m. j. dyer and g. m. cohen, cell death differ 2009, 16, 1030-1039. 5. r. yu, s. mandlekar, t. h. tan and a. n. kong, j biol chem 2000, 275, 9612-9619. 6. s. yamamoto, k. seta, c. morisco, s. f. vatner and j. sadoshima, j mol cell cardiol 2001, 33, 1829-1848.
CHELERYTHRINE CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21149 | 58 |
View Lastest Price from CHELERYTHRINE CHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-13 | Chelerythrine chloride
3895-92-9
|
US $80.00 / kg | 1kg | 99% | 100MT | Hebei baicao biology science and technology co., ltd | |
 |
2019-07-06 | CHELERYTHRINE CHLORIDE
3895-92-9
|
US $1.00-1.00 / kg | 1 mg | 99% | 100KG | Career Henan Chemical Co |
-
- Chelerythrine chloride
3895-92-9
- US $80.00 / kg
- 99%
- Hebei baicao biology science and technology co., ltd
-
- CHELERYTHRINE CHLORIDE
3895-92-9
- US $1.00-1.00 / kg
- 99%
- Career Henan Chemical Co