PD 0325901
- CAS No.
- 391210-10-9
- Chemical Name:
- PD 0325901
- Synonyms
- Mirdametinib;PD325901;Mirdametinib (PD0325901);CS-52;PD 032590;PD 0325901;PD-0235901;PD0325901, >=98%;MEK1/2 Inhibitor III;PD0325901 (PD325901)
- CBNumber:
- CB42464161
- Molecular Formula:
- C16H14F3IN2O4
- Molecular Weight:
- 482.19
- MDL Number:
- MFCD08435926
- MOL File:
- 391210-10-9.mol
- MSDS File:
- SDS
| Melting point | 112-114°C |
|---|---|
| Density | 1.817±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble20mg/mL, clear |
| form | White to off-white solid |
| pka | 13.45±0.20(Predicted) |
| color | white to off-white |
| optical activity | [α]/D -1.8 to -3.5°, c = 1 mg/mL in methanol |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChIKey | SUDAHWBOROXANE-SECBINFHSA-N |
| FDA UNII | 86K0J5AK6M |
| NCI Drug Dictionary | mirdametinib |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H373-H413 | |||||||||
| Precautionary statements | P260-P264-P270-P273-P301+P310-P314 | |||||||||
| Hazard Codes | T,N | |||||||||
| Risk Statements | 25-48-50 | |||||||||
| Safety Statements | 22-36/37/39-61 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29242990 | |||||||||
| NFPA 704 |
|
PD 0325901 price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 444968 | InSolution? MEK1/2 Inhibitor III, PD0325901 | 391210-10-9 | 5mg | $230 | 2024-03-01 | Buy |
| Sigma-Aldrich | 444966 | MEK1/2 Inhibitor III | 391210-10-9 | 5mg | $230 | 2024-03-01 | Buy |
| Cayman Chemical | 13034 | PD 0325901 ≥98% | 391210-10-9 | 5mg | $43 | 2024-03-01 | Buy |
| Cayman Chemical | 13034 | PD 0325901 ≥98% | 391210-10-9 | 1mg | $25 | 2023-06-20 | Buy |
| Sigma-Aldrich | PZ0162 | PD 0325901 ≥98% (HPLC) | 391210-10-9 | 5mg | $155 | 2024-03-01 | Buy |
PD 0325901 Chemical Properties,Uses,Production
Description
PD 325901 (391210-10-9) is a selective non-ATP competitive MEK inhibitor (IC50 = 0.33 nM).1 Inhibits growth and/or proliferation of a variety of cancer cells.2 Enhances self-renewal of embryonic stem cells.3 In combination with vitamin C, synergistically induces hypomethylation of mouse embryonic stem cells.4 In combination with CHIR-99021 and A83-01 induces generation of ground state iPS cells from human and rat somatic cells.5
Chemical Properties
White to Off-White Solid
Uses
PD 0325901 has been used as an inhibitor in extracellular signal-regulated kinase (ERK) inhibition assay in primed induced pluripotent stem cells, RKO colorectal cancer cell line and human embryonic stem cells(hESCs).
Uses
The mitogenic extracellular kinase 1/2 (MEK1/2) inhibitor
Definition
ChEBI: A hydroxamic acid ester that is benzhydroxamic acid (N-hydroxybenzamide) in which the hydroxamic acid group has been converted to the corresponding 2,3-dihydroxypropyl ester and in which the benzene ring has been substituted at position by a (2-fluoro-4-iodophenyl)amino group and at positions 3 and 4 by fluorines (the R enantiomer).
Biochem/physiol Actions
PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 was inactive against a panel of 27 other kinases. PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice.
storage
-20°C
References
1) Sebolt-Leopold et al. (2004), The biological profile of PD0325901: A second generation analog of CI-1040 with improved pharmaceutical potential; Proc. Amer. Assoc. Cancer Res., 45 925 2) Ciuffreda et al. (2009), Growth-inhibitor and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations; Neoplasia, 11 720 3) Ai et al. (2016), Maintenance of Self-Renewal and Pluripotency in J1 Mouse Embryonic Stem Cells through Regulating Transcription Factor and MicroRNA Expression Induced by PD0325901; Stem Cells Int., 2016 1792573 4) Li et al. (2016), MEK inhibitor PD0325901 and vitamin C synergistically induce hypomethylation of mouse embryonic stem cells; Oncotarget, 7 39730 5) Li et al. (2009), Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors; Cell Stem Cell, 4 16
PD 0325901 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
View Lastest Price from PD 0325901 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-08-27 | PD 0325901
391210-10-9
|
US $3.00 / KG | 3KG | 98% | 1kg,5kg,100kg | Career Henan Chemical Co |
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- PD 0325901
391210-10-9
- US $3.00 / KG
- 98%
- Career Henan Chemical Co