Decernotinib
- CAS No.
- 944842-54-0
- Chemical Name:
- Decernotinib
- Synonyms
- VX 509;CS-1650;adelatinib;VRT 831509;Decernotinib;VX-509;VRT-831509;Decernotinib(VX-509);VX-509;? VRT-831509; ADELATINIB;Decernotinib (VX-509,adelatinib);(R)-2-((2-(1H-Pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-2-methyl-N-(2,2,2-trifluoroethyl)butanamide
- CBNumber:
- CB42718363
- Molecular Formula:
- C18H19F3N6O
- Molecular Weight:
- 392.38
- MDL Number:
- MFCD27987896
- MOL File:
- 944842-54-0.mol
- MSDS File:
- SDS
| Density | 1.363±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | 4°C, protect from light, stored under nitrogen |
| solubility | insoluble in H2O; ≥16.95 mg/mL in DMSO; ≥2.92 mg/mL in EtOH with ultrasonic |
| form | solid |
| pka | 12.36±0.40(Predicted) |
| FDA UNII | MZK2GP0RHK |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H302-H335-H315 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| NFPA 704 |
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Decernotinib price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19513 | VX-509 ≥98% | 944842-54-0 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 19513 | VX-509 ≥98% | 944842-54-0 | 5mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 19513 | VX-509 ≥98% | 944842-54-0 | 10mg | $172 | 2024-03-01 | Buy |
| Cayman Chemical | 19513 | VX-509 ≥98% | 944842-54-0 | 25mg | $384 | 2024-03-01 | Buy |
| TRC | D225580 | Decernotinib | 944842-54-0 | 50mg | $375 | 2021-12-16 | Buy |
Decernotinib Chemical Properties,Uses,Production
Uses
Decernotinib is a potent and selective Janus kinase 3 inhibitor for treatment of autoimmune diseases.
Biological Activity
decernotinib(vx-509)is a novel, potent and selective inhibitor of jak3 with ki value of 2 nm [1].the janus kinase family consists of four members: jak1, jak2, jak3, and tyk2. janus kinase 3 (jak3) is mainly expressed in lymphocytes, which are cells important to the immune response associated with many diseases, including rheumatoid arthritis (ra) [1].decernotinib(vx-509)is a novel, potent, selective and orally available jak3 inhibitor for the treatment of autoimmune diseases. vx-509 inhibited jak1, jak2, jak3, and tyk2 with ki values of 11, 13, 2 and 11 nm, respectively. in ht-2 or tf-1 cells, vx-509 inhibited jak3/1- or jak2-mediated phosphorylation of stat5 following stimulation with il-2 or gmcsf with ic50 values of 99 and 2600 nm, respectively [1].in the rat host versus graft (hvg) model, vx-509 at 50 mg/kg bid or 100 mg/kg qd significantly and dose-dependently inhibited popletial lymph node (pln) hyperplasia by 66% and 94%, respectively, relative to cyclosporin a (csa). vx-509 also significantly reduced cd25 expression. these results suggested that vx-509 showed significant dose-dependent immunosuppressive activity and effectively inhibited t-cell activation [1]. in the rat collagen-induced arthritis model, vx-509 dose-dependently reduced ankle swelling and paw weight, and improved paw histopathology scores. in oxazolone-induced delayed-type hypersensitivity mouse model, vx-509 reduced the t cell-mediated inflammatory response in skin [2].
References
[1]. farmer lj, ledeboer mw, hoock t, et al. discovery of vx-509 (decernotinib): a potent and selective janus kinase 3 inhibitor for the treatment of autoimmune diseases. j med chem, 2015, 58(18): 7195-7216.
[2]. mahajan s, hogan jk, shlyakhter d, et al. vx-509 (decernotinib) is a potent and selective janus kinase 3 inhibitor that attenuates inflammation in animal models of autoimmune disease. j pharmacol exp ther, 2015, 353(2): 405-414.
Decernotinib Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Chongqing Chemieliva Pharmaceutical Co., Ltd. | 023-67770219 | jessica.hu@chemieliva.com | China | 1423 | 60 |
View Lastest Price from Decernotinib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Decernotinib
944842-54-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Decernotinib
944842-54-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-07-06 | Decernotinib
944842-54-0
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- Decernotinib
944842-54-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Decernotinib
944842-54-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Decernotinib
944842-54-0
- US $2.00 / kg
- 99%
- Career Henan Chemical Co