2-Chloro-1-p-tolyl-ethanone
- CAS No.
- 4209-24-9
- Chemical Name:
- 2-Chloro-1-p-tolyl-ethanone
- Synonyms
- 4-(2-chloroacetyl)toluene;p-Methylphenacyl chloride;CHLOROMETHYL P-TOLYL KETONE;2-CHLORO-1-P-TOLYL-ETHANONE;p-Methyl-2-chloroacetophenone;4'-Methyl-2-chloroacetophenone;A-CHLORO-4-METHYL ACETOPHENONE;2-CHLORO-4'-METHYLACETOPHENONE;α-Chloro-4'-methylacetophenone;Chloromethyl 4-methylphenyl ketone
- CBNumber:
- CB4322474
- Molecular Formula:
- C9H9ClO
- Molecular Weight:
- 168.62
- MDL Number:
- MFCD00972094
- MOL File:
- 4209-24-9.mol
| Melting point | 57.5°C |
|---|---|
| Boiling point | 238.18°C (rough estimate) |
| Density | 1.1115 (rough estimate) |
| refractive index | 1.5620 (estimate) |
| InChI | InChI=1S/C9H9ClO/c1-7-2-4-8(5-3-7)9(11)6-10/h2-5H,6H2,1H3 |
| InChIKey | HGLJRZYKFVJSEE-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC=C(C)C=C1)CCl |
| CAS DataBase Reference | 4209-24-9(CAS DataBase Reference) |
2-Chloro-1-p-tolyl-ethanone price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C374215 | 2-chloro-1-(4-methylphenyl)ethanone | 4209-24-9 | 10mg | $45 | 2021-12-16 | Buy |
| AK Scientific | P247 | 4-(2-Chloroacetyl)toluene | 4209-24-9 | 100mg | $216 | 2021-12-16 | Buy |
| AK Scientific | P247 | 4-(2-Chloroacetyl)toluene | 4209-24-9 | 250mg | $253 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0024009 | CHLOROMETHYL P-TOLYL KETONE 95.00% | 4209-24-9 | 1G | $692.46 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0024009 | CHLOROMETHYL P-TOLYL KETONE 95.00% | 4209-24-9 | 2.5G | $932.6 | 2021-12-16 | Buy |
2-Chloro-1-p-tolyl-ethanone Chemical Properties,Uses,Production
Uses
2-chloro-1-(4-methylphenyl)ethanone (cas# 4209-24-9) can be used for preparation of acetophenone derivatives, which are known to be fungicides that control phytopathogenic fungi. In addition, this compound can be used for synthesis of clinafloxacin triazole hybrids, which are also known for the their antifungal and antibacterial activity. Moreover, this compound was found to inhibit (uncompetitively to ATP) pyruvate dehydrogenase (PDH), meaning it inhibits further glucose oxidation. That is why this compound can potentially be used to treat such conditions as diabetes and/or ischemia.
Preparation
To a suspension of anhydrous aluminum chloride (5.60 g, 40 mmol) in anhydrous toluene (40 mL), chloroacetyl chloride (4.52 g, 40 mmol) was slowly added dropwise. After the aluminum chloride had dissolved, the mixture was heated slowly to 80 °C and held at that temperature for 2 h, then cooled and poured into crushed ice (100 g)containing concentrated hydrochloric acid (10 mL). The reaction liquid is extracted by toluene, concentrated, and dried to obtain 2-Chloro-1-p-tolyl-ethanone.
Synthesis Reference(s)
Synthetic Communications, 20, p. 1625, 1990 DOI: 10.1080/00397919008053082
Hazard
Chloromethyl p-tolyl ketone is a danger compound.
H290 (33.33%): May be corrosive to metals [Warning Corrosive to Metals]
H302 (66.67%): Harmful if swallowed [Warning Acute toxicity, oral]
H314 (33.33%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
H315 (66.67%): Causes skin irritation [Warning Skin corrosion/irritation]
H318 (66.67%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
H319 (33.33%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H334 (66.67%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
H335 (66.67%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
2-Chloro-1-p-tolyl-ethanone Preparation Products And Raw materials
2-Chloro-1-p-tolyl-ethanone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Xinchem Co., Ltd. | +86-021-34123252 +8618049800532 | xinchem@xinchem.com | China | 49 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Hebei Duling International Trade Co. LTD | +8618032673083 | sales05@hbduling.cn | China | 15744 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9425 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19639 | 58 |
View Lastest Price from 2-Chloro-1-p-tolyl-ethanone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-10-22 | Chloromethyl p-tolyl ketone
4209-24-9
|
US $0.00-0.00 / drums | 1drums | 99%min. | 10tons | Shanghai Xinchem Co., Ltd. | |
 |
2022-09-07 | Chloromethyl p-tolyl ketone
4209-24-9
|
US $0.00-0.00 / KG | 1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- Chloromethyl p-tolyl ketone
4209-24-9
- US $0.00-0.00 / drums
- 99%min.
- Shanghai Xinchem Co., Ltd.
-
- Chloromethyl p-tolyl ketone
4209-24-9
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.