Nitidine chloride
- CAS No.
- 13063-04-2
- Chemical Name:
- Nitidine chloride
- Synonyms
- NITIDINE;Angolinine;Nitidine chloride;NITIDINE CHLORIDE (RG);ShinyleafPricklyashRoot;dimethoxy-12-methyl-,chloride;Nitidine, chloride (6CI, 7CI, 8CI);[1,3]Dioxolo[4,5]benzo[1,2-c]phenanthridinium, 2,3-;Nitidine chloride, 98%, from Zanthoxylum nitidum (Roxb.) DC.;2,3-Dimethoxy-12-methyl-(1,3)-benzodioxolo(5,6-c)phenanthridinium chloride
- CBNumber:
- CB4341347
- Molecular Formula:
- C21H18NO4+
- Molecular Weight:
- 348.37
- MDL Number:
- MFCD01659688
- MOL File:
- 13063-04-2.mol
| Melting point | 283-286 °C |
|---|---|
| storage temp. | -20°C |
| solubility | DMSO: soluble1mg/mL, clear (warmed) |
| form | powder |
| color | white to beige |
| InChIKey | QLDAACVSUMUMOR-UHFFFAOYSA-M |
| FDA UNII | XO8WQL69T8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DF4935500 | |||||||||
| HS Code | 29399990 | |||||||||
| Toxicity | mouse,LD50,intraperitoneal,98980ug/kg (98.98mg/kg),National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, | |||||||||
| NFPA 704 |
|
Nitidine chloride price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29223 | Nitidine (chloride) | 13063-04-2 | 10mg | $107 | 2024-03-01 | Buy |
| Cayman Chemical | 29223 | Nitidine (chloride) | 13063-04-2 | 100mg | $929 | 2024-03-01 | Buy |
| Cayman Chemical | 29223 | Nitidine (chloride) | 13063-04-2 | 5mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 29223 | Nitidine (chloride) | 13063-04-2 | 25mg | $249 | 2024-03-01 | Buy |
| TRC | N490110 | Nitidine chloride | 13063-04-2 | 25mg | $295 | 2021-12-16 | Buy |
Nitidine chloride Chemical Properties,Uses,Production
Description
This quaternary alkaloid occurs primarily in Zanthoxylum nitidum (Lam.) DC but has also been found in several species of Fagara. It is normally isolated as the chloride which forms bright yellow needles when recrystallized from EtOH-HCl. The crystals decompose on heating to 240°C yielding a product having m.p. 285-6°C. The iodide also forms yellow needles and undergoes a similar trans_x0002_formation at the same temperature to yield a product with the same melting point, possibly identical to that obtained from the chloride. The crystalline acetate, m.p. 255-260°C and the pseudocyanide, m.p. 215-6°C and decomposing completely at 234°C in vacuo have also been prepared. A periodide, which fonns chocolate-brown needles when crystallized from Me2CO, m.p. 300-1 °c (dec.) is useful for characterizing the base.
Uses
Nitidine Chloride shows the ability to inhibit hepatic cancer growth through modulation of signaling pathways.
Preparation
A solution of 1555 (0.102 g, 0.278 mmol) and triphosgene (0.179 g, 0.602 mmol) in acetonitrile (2.5 mL) was stirred at 60 C° (bath temperature) for 0.5 h. After the addition of ice/water, a yellow precipitate was collected by filtration and recrystallized from ethanol/diethyl ether to directly afford nitidine chloride (0.098 g, 91%); mp 285–292 C°.
An isocyano group can serve as both a protecting group for the amino function, and, due to its electronic effect, as an activating group as well. These two functionalities are employed in a synthetic route whereby an amino function has to be protected and a condensation reaction is performed at the a-carbon atom, for which activation is required.
3,4-Fused tryptophan analogues 1563 and 1564 contain a ring that bridges the a-carbon and the 4-position of the indole ring, thus limiting the conformational flexibility of the side chain. The synthesis proceeds from N-formylated 40-bromotryptophan 1558 via isocyanide 1559, 2-propenoate 1560, and Pd-catalyzed cyclization of the a-2-propenyl dl-tryptophan derivatives 1561 and 1562 to give both the seven- and eight-membered constrained ring analogues 1564 and 1563. Dehydration of the formamide 1558 with triphosgene affords the isocyanide 1559 in 75% (87%) yield.
Biochem/physiol Actions
Nitidine chloride is a natural product with anti-cancer activity. Its mechanism of action likely involves several pathways. Nitidine chloride has been found to inhibit topoisomerase I and topoisomerase II, induce cell apoptosis by activation of the caspase-dependent pathway, suppress c-Src/FAK associated signaling pathways and suppress Janus kinase 2/STAT3 signaling and the expression of STAT3-dependent target genes, including cyclin D1, Bcl-xL, and VEGF. Nitidine chloride has also been found to have anti-malaria activity.
References
Arthur, Hui, Ng., Chern. Ind., 1514 (1958)
Arthur, Hui, Ng.,J. Chern. Soc., 1840 (1959)
Kuck, Albonico, Deulofeu., Chern. Ind., 945 (1966)
Nitidine chloride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
View Lastest Price from Nitidine chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-12 | Nitidine chloride
13063-04-2
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | |
 |
2023-02-24 | Nitidine Chloride
13063-04-2
|
US $0.00 / mg | 5mg | ≥97%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2019-07-06 | Nitidine chloride
13063-04-2
|
US $1.00 / kg | 1g | 99% | 100KG | Career Henan Chemical Co |
-
- Nitidine chloride
13063-04-2
- US $0.00 / kg
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd
-
- Nitidine Chloride
13063-04-2
- US $0.00 / mg
- ≥97%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Nitidine chloride
13063-04-2
- US $1.00 / kg
- 99%
- Career Henan Chemical Co