ChemicalBook >> CAS DataBase List >>AG 1478 HYDROCHLORIDE
AG 1478 HYDROCHLORIDE
- CAS No.
- 153436-53-4
- Chemical Name:
- AG 1478 HYDROCHLORIDE
- Synonyms
- -1478);AG-1478;AG1478HCl;NSC 693255;AG-1478, >98%;AG-1478 AG1478;AG-1478 (NSC-693255);-1478 (Tyrphostin Ag;AG 1478 HYDROCHLORIDE;AG-1478 (Tyrphostin AG-1478)
- CBNumber:
- CB4728982
- Molecular Formula:
- C16H14ClN3O2
- Molecular Weight:
- 315.75
- MDL Number:
- MFCD06804597
- MOL File:
- 153436-53-4.mol
- MSDS File:
- SDS
Last updated:2023-06-08 09:01:57
| Melting point | 247 °C(dec.) |
|---|---|
| Boiling point | 458.5±45.0 °C(Predicted) |
| Density | 1.337 |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | insoluble in H2O; ≥15.8 mg/mL in DMSO; ≥2.38 mg/mL in EtOH with gentle warming |
| pka | 5.54±0.30(Predicted) |
| form | White to light yellow solid. |
| color | Light orange to Yellow to Green |
| λmax | 332nm(lit.) |
| FDA UNII | SUH0SEZ9HY |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P310 | |||||||||
| RTECS | VA0953000 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
AG 1478 HYDROCHLORIDE price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T2944 | Tyrphostin AG 1478 >98.0%(HPLC) | 153436-53-4 | 25mg | $464 | 2024-03-01 | Buy |
| Cayman Chemical | 10010244 | AG 1478 ≥98% | 153436-53-4 | 1mg | $22 | 2024-03-01 | Buy |
| Cayman Chemical | 10010244 | AG 1478 ≥98% | 153436-53-4 | 5mg | $95 | 2024-03-01 | Buy |
| Cayman Chemical | 10010244 | AG 1478 ≥98% | 153436-53-4 | 10mg | $167 | 2024-03-01 | Buy |
| Cayman Chemical | 10010244 | AG 1478 ≥98% | 153436-53-4 | 25mg | $363 | 2024-03-01 | Buy |
AG 1478 HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
A highly potent and specific EGFR tyrosine kinase inhibitor with an IC50 of 3 nM.
Uses
AG 1478 Hydrochloride is an epidermal growth factor receptor tyrosine kinase inhibior (EGFR inhibtor).
Definition
ChEBI: Tyrphostin AG 1478 is a member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist. It has a role as an epidermal growth factor receptor antagonist, an antineoplastic agent, a geroprotector and an antiviral agent. It is a member of quinazolines, an aromatic ether and a member of monochlorobenzenes.
Biological Activity
Potent and selective inhibitor of epidermal growth factor receptor kinase (IC 50 values 3 nM for EGFR and > 100 μ M for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro (IC 50 = 1 μ M).
target
EGFR
AG 1478 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 142)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from AG 1478 HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-06 | AG 1478 HYDROCHLORIDE
153436-53-4
|
US $1.00 / KG | 1KG | 98% | 20kg | Career Henan Chemical Co |
-
- AG 1478 HYDROCHLORIDE
153436-53-4
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
153436-53-4(AG 1478 HYDROCHLORIDE)Related Search:
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N-(3-CHLOROPHENYL)-6,7-DIMETHOXY-4-QUINAZOLINANINE HYDROCHLORIDE
4-(3-CHLOROANILINO)-6,7-DIMETHOXYQUINAZOLINE HCL
4-(3-CHLOROANILINO)-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE
AG-1478
AG 1478 HYDROCHLORIDE
Tyrphostin AG 1478, free base >99%
NSC 693255
(3-Chlorophenyl)(6,7-dimethoxyquinazolin-4-yl)amine
AG1478HCl
AG-1478 (Tyrphostin AG-1478)
AG-1478 (NSC-693255)
AG-1478, 97.5%, a selective EGFR inhibitor
AG1478; TYRPHOSTIN AG1478; AG 1478; NSC 693255
AG1478; TYRPHOSTIN AG1478; AG 1478
AG-1478, >98%
-1478 (Tyrphostin Ag
-1478)
AG 1478 HYDROCHLORIDE USP/EP/BP
AG-1478 AG1478
AG-1478 hydrochloride/Tyrphostin AG 1478
153436-53-4
C16H14ClN3O2HCl
Inhibitors
API
Inhibitor