Nisoldipine | 63675-72-9

Nisoldipine Properties

Melting point	147-148°C
Boiling point	503.3±50.0 °C(Predicted)
Density	1.205±0.06 g/cm3(Predicted)
storage temp.	room temp
solubility	DMSO: >10mg/mL
pka	2.67±0.70(Predicted)
form	powder
color	yellow
Merck	14,6565
InChIKey	VKQFCGNPDRICFG-UHFFFAOYSA-N
CAS DataBase Reference	63675-72-9(CAS DataBase Reference)
FDA UNII	4I8HAB65SZ
NIST Chemistry Reference	Nisoldipine(63675-72-9)
ATC code	C08CA07

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

Hazard Codes

Xn

Risk Statements

20/21/22

Safety Statements

36

WGK Germany

3

RTECS

US7975600

HS Code

2933399090

NFPA 704

	0
3		0

Nisoldipine price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	N0165	Nisoldipine ≥98% (HPLC)	63675-72-9	10mg	$84.1	2024-03-01	Buy
Sigma-Aldrich	N0165	Nisoldipine ≥98% (HPLC)	63675-72-9	50mg	$351	2024-03-01	Buy
TCI Chemical	N0900	Nisoldipine >98.0%(HPLC)(N)	63675-72-9	1g	$91	2024-03-01	Buy
TCI Chemical	N0900	Nisoldipine >98.0%(HPLC)(N)	63675-72-9	5g	$227	2024-03-01	Buy
Alfa Aesar	H37972	Nisoldipine 98%	63675-72-9	1g	$119	2023-06-20	Buy

Product number	Packaging	Price	Buy
N0165	10mg	$84.1	Buy
N0165	50mg	$351	Buy
N0900	1g	$91	Buy
N0900	5g	$227	Buy
H37972	1g	$119	Buy

Nisoldipine Chemical Properties,Uses,Production

Description

Nisoldipine D4 is another long-acting dihydropyridine calcium channel blocker effective in the treatment of hypertension and angina pectoris. It is reported to have little or no cardiodepressive activity and to be more effective than nifedipine in reducing blood pressure in hypertensives. Nisoldipine has also been shown to be effective in the management of congestive heart failure. Reduction in dosage is necessary in patients with hepatic, but not renal impairment.

Chemical Properties

Nisoldipine D4 is Light Tan Crystals

Originator

Bayer AG (Germany)

Uses

urease inhibitor

Uses

Labeled Nisoldipine, intended for use as an internal standard for the quantification of Nisoldipine by GC- or LC-mass spectrometry.

Uses

Dihydropyridine calcium channel blocker. Antihypertensive and antianginal

Definition

ChEBI: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a methoxycarbonyl group at position 3, an o-nitrophenyl group at position 4, and an isobutoxycarbonyl group at position 5. The racemate, calcium channel blocker, is used in the treatment of hypertension and angina pectoris.

Manufacturing Process

Boiling a solution of 12.7 g of 2'-nitrobenzylideneacetoacetic acid methyl ester and 7.1 g of β-amino-crotonic acid isopropyl ester in 50 ml of methanol for 10 hours yielded 2,6-dimethyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-3,5- dicarboxylic acid 3-methyl ester-5-isopropyl ester of melting point 174°C (from ethanol). Yield 48% of theory.

brand name

Sular (Sciele);Baymycard.

Therapeutic Function

Coronary vasodilator

General Description

In vitro studies show that the effects ofnisoldipine, 1,4-dihydro-2, 6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinecarboxylic acid methyl 2-methylpropyl ester(Sular), on contractile processes are selective, with greaterpotency on vascular smooth muscle than on cardiac muscle.
Nisoldipine is highly metabolized, with five majormetabolites identified. As with most of the dihydropyridines,the cytochrome P450 (CYP) 3A4 isozyme is mainlyresponsible for the metabolism of nisoldipine. The majorbiotransformation pathway appears to involve the hydroxylationof the isobutyl ester side chain. This particular metabolitehas approximately 10% of the activity of the parentcompound.

Biochem/physiol Actions

L-type (CaV1.2) calcium channel blocker; dihydropyridine-type calcium channel blocker with selectivity for smooth muscle (CaV1.2b) over cardiac muscle (CaV1.2a). Arterial vasodilator and antihypertensive agent.

Nisoldipine synthesis

Synthesis of Nisoldipine from Isobutyl 2-(2-Nitro-Benzylidene)Acetoacetate and methyl 3-aminocrotonate

Nisoldipine Preparation Products And Raw materials

Raw materials

Methyl 3-aminocrotonate 2-Nitrobenzaldehyde Isobutyl acetoacetate nifedipine iMpurity C Nifedipine

Isobutyl 2-(2-Nitro-Benzylidene)Acetoacetate Nicardipine 2,3-Diamino-2,3-dimethylbutane methyl 3-aminocrotonate

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Preparation Products

Nisoldipine Suppliers

Global( 372)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12470	58
Henan Tengmao Chemical Technology Co. LTD	+8615238638457	salesvip2@hntmhg.com	China	415	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Jinan Jianfeng Chemical Co., Ltd	0531-88110457; +8615562555968	info@pharmachemm.com	China	222	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hebei Jimi Trading Co., Ltd.	+86 319 5273535	bestoneforyou@sina.com	CHINA	288	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8822	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Henan Tengmao Chemical Technology Co. LTD	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Jinan Jianfeng Chemical Co., Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
Hebei Jimi Trading Co., Ltd.	58
Hebei Guanlang Biotechnology Co., Ltd.	58
Chongqing Chemdad Co., Ltd	58

View Lastest Price from Nisoldipine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-12-29	Nisoldipine 63675-72-9	US $110.00-90.00 / kilograms	1kilograms	99%	5000 tons	Henan Tengmao Chemical Technology Co. LTD
2023-09-05	Nisoldipine 63675-72-9	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2023-08-16	Nisoldipine 63675-72-9	US $500.00 / KG	1KG	>99%	50000kg/Month	Weijer International Trade (Hebei) Co., Ltd

Nisoldipine
63675-72-9
US $110.00-90.00 / kilograms
99%
Henan Tengmao Chemical Technology Co. LTD

Nisoldipine
63675-72-9
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

Nisoldipine
63675-72-9
US $500.00 / KG
>99%
Weijer International Trade (Hebei) Co., Ltd

Nisoldipine Spectrum

Nisoldipine(63675-72-9)¹HNMR

63675-72-9(Nisoldipine)Related Search:

Dimethyl sulfoxide Dimethyl sulfide Dimethyl fumarate 2,6-Lutidine Dimethyl sebacate

Dimethyl sulfate Dimethyl carbonate 2,5-PYRIDINEDICARBOXYLIC ACID 4-Nitrobenzoic acid ETHANE

Dihydromyrcenol Quinolinic acid N,N-Dimethylformamide Dimethyl ether Nitrendipine

Nicardipine Nimodipine Doxazosin

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SYSCOR Nisoldipin 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID METHYL 2-METHYLPROPYL ESTER Nisoldipine-d6 3-Isobutyl 5-Methyl 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid-3-methyl 5-(2-methylpropyl) ester (±)-Isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-isobutyl ester Nikameal Ninobarucin Nisomynard 3-Methyl 5-(2-Methylpropyl) (4R)-2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Nisoldipine (Sular) 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(2-nitrophenyl)-, 3-Methyl 5-(2-Methylpropyl)ester Nisoldipine-d4 methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Nisoldipine, >=99% 5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-met hyl2-methylpropylester BAYMYCARD BAY K 5552 ZADIPINA ISOBUTYL METHYL (- 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE Baymycard, Norvasc, Syscor, Zadipina, 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Methyl 2-methylpropyl Ester 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-methylpropyl ester (9CI) Nisocor Sular Syseor 2，6-Dimethyl-4-(2-nitmphenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl 2-methylpropyl ester NORVASC NISOLDIPINE NISOLIDIPINE Nisoldipine> Nisoldipine Nisoldipine NisoL 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Isobutyl Methyl Ester Nisoldipine USP/EP/BP NisoldipineQ: What is Nisoldipine Q: What is the CAS Number of Nisoldipine Q: What is the storage condition of Nisoldipine Q: What are the applications of Nisoldipine hexakis(dihydrogen phosphate) Nisoldipine(BAY-k 5552 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-(2-methylpropyl) ester 63675-72-9 C20H18N2O6D6 C20H24N2O6 Calcium channel Cardiovascular APIs Active Pharmaceutical Ingredients All Inhibitors Inhibitors Intermediates & Fine Chemicals Pharmaceuticals