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Alpelisib (BYL719)

Alpelisib (BYL719) Structure
Alpelisib (BYL719) structure
CAS No.
1217486-61-7
Chemical Name:
Alpelisib (BYL719)
Synonyms
Alpelisib;Piqray;BYL-719;CS-614;100803;BLV-719;BYL-719 /BYL719;Alpelisib (BYL719);BYL-719(Alpelisib);Alpelisib (BLY-719
CBNumber:
CB52604234
Molecular Formula:
C19H22F3N5O2S
Molecular Weight:
441.47
MDL Number:
MFCD22417085
MOL File:
1217486-61-7.mol
MSDS File:
SDS
Last updated:2024-01-17 13:43:51
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Alpelisib (BYL719) Properties

Density 1.391
storage temp. Store at -20°C
solubility ≥22.07 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form White solid.
pka 6.29±0.70(Predicted)
InChIKey STUWGJZDJHPWGZ-LBPRGKRZSA-N
SMILES N1(C(NC2=NC(C)=C(C3C=CN=C(C(C)(C)C(F)(F)F)C=3)S2)=O)CCC[C@H]1C(N)=O
NCI Dictionary of Cancer Terms alpelisib
FDA UNII 08W5N2C97Q
NCI Drug Dictionary alpelisib
ATC code L01EM03

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H373
Precautionary statements  P260-P314-P501
HS Code  29341000

Alpelisib (BYL719) price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16986 BYL719 ≥98% 1217486-61-7 5mg $54 2024-03-01 Buy
Cayman Chemical 16986 BYL719 ≥98% 1217486-61-7 10mg $98 2024-03-01 Buy
Cayman Chemical 16986 BYL719 ≥98% 1217486-61-7 25mg $207 2024-03-01 Buy
TRC M331055 (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide 1217486-61-7 25mg $190 2021-12-16 Buy
ApexBio Technology A8346 BYL-719 1217486-61-7 20mg $200 2021-12-16 Buy
Product number Packaging Price Buy
16986 5mg $54 Buy
16986 10mg $98 Buy
16986 25mg $207 Buy
M331055 25mg $190 Buy
A8346 20mg $200 Buy

Alpelisib (BYL719) Chemical Properties,Uses,Production

Description

BYL719 is an inhibitor of phosphoinositide 3-kinase α (PI3Kα; IC50s = 4.6, 4, and 4.8 nM for wild-type, E545K mutant, and H1047R mutant PI3K, respectively). It is selective for PI3Kα over PI3Kβ, PI3Kδ, PI3Kγ, and PI4Kβ (IC50s = 1,156, 290, 250, and 581 nM, respectively), as well as VPS34, mTOR, DNA-PK, and ATR (IC50s = >9,100 nM for all). BYL719 (12.5, 25, and 50 mg/kg) reduces tumor volume in a PI3Kα-dependent Rat1-myr-p110α mouse xenograft model. It also reduces tumor burden in THP-1 acute myeloid leukemia (AML) and MCF-7 breast cancer mouse xenograft models. Formulations containing BYL719 have been used in the treatment of advanced or metastatic breast cancer.

Uses

(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide is a newly developed phosphatidylinositol-3-kinase (PI3K) inhibitor and a mTOR inhibitor for the treatment of proliferative diseases.

Uses

(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide is a newly developed phosphatidylinositol-3-kinase (PI3K) inhibitor and a mTOR inhibit or for the treatment of proliferative diseases.

Definition

ChEBI: (2S)-N1-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)-4-pyridinyl]-2-thiazolyl]pyrrolidine-1,2-dicarboxamide is a proline derivative.

target

PI3Kα

References

1. furet p, guagnano v, fairhurst ra et al. discovery of nvp-byl719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. bioorg med chem lett 2013; 23: 3741-3748. 2. azab f, vali s, abraham j et al. pi3kca plays a major role in multiple myeloma and its inhibition with byl719 decreases proliferation, synergizes with other therapies and overcomes stroma-induced resistance. br j haematol 2014; 165: 89-101. 3. juric d, argiles g, burris h et al. phase i study of byl719, an alpha-specific pi3k inhibitor, in patients with pik3ca mutant advanced solid tumors: preliminary efficacy and safety in patients with pik3ca mutant er-positive (er+) metastatic breast cancer (mbc). cancer res 2012; 72: p6-10.

Alpelisib (BYL719) Preparation Products And Raw materials

Raw materials

Acetamide,N-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]- 4-Methyl-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine 4-methyl-2-(2,2,2-trifluoro-1-methyl-1-trimethylsilanyloxy-ethyl)pyridine 1,1,1-trifluoro-2-(4-methylpyridin-2-yl)propan-2-ol
1,1,1-trifluoro-2-(4-methylpyridin-2-yl)propan-2-yl methanesulfonate N-(4-Methyl-5-(2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)-1H-iMidazole-1-carboxaMide phenyl 4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-ylcarbamate L-Prolinamide 1-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)propan-2-one
2-Acetyl-4-methylpyridine 2,4-Lutidine

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Preparation Products

Alpelisib (BYL719) Suppliers

Global( 216)Suppliers
Supplier Tel Email Country ProdList Advantage
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11013 58
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Xi'an Yutbon Pharmaceutical Technology Co., Ltd 		029-81140587 +8618717328141 sales@yutbon.com China 437 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Supplier Advantage
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Hubei Jusheng Technology Co.,Ltd. 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58
Xi'an Yutbon Pharmaceutical Technology Co., Ltd 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58

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  • Alpelisib -an orally available phosphatidylinositol 3-kinase (PI3K) inhibitor with specific activity against PI3K alpha (PI3Kα....
  • Jan 17，2024

View Lastest Price from Alpelisib (BYL719) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide pictures 2024-04-17 (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
1217486-61-7
 US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
Alpelisib (BYL719) pictures 2024-01-02 Alpelisib (BYL719)
1217486-61-7
 US $50.00-500.00 / kg 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd
Alpelisib (BYL719) pictures 2023-09-13 Alpelisib (BYL719)
1217486-61-7
 US $0.00-0.00 / KG 10mg 99.0%HPLC 1~10kg Shandong Jirun Biomedical Technology Co., Ltd.
  • Alpelisib (BYL719) pictures
  • Alpelisib (BYL719)
    1217486-61-7
  • US $50.00-500.00 / kg
  • 0.99
  • Zibo Hangyu Biotechnology Development Co., Ltd
  • Alpelisib (BYL719) pictures
  • Alpelisib (BYL719)
    1217486-61-7
  • US $0.00-0.00 / KG
  • 99.0%HPLC
  • Shandong Jirun Biomedical Technology Co., Ltd.

Alpelisib (BYL719) Spectrum

Alpelisib (BYL719)(1217486-61-7)1HNMR

1217486-61-7( Alpelisib (BYL719))Related Search:

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(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide BYL-719 /BYL719 BLV-719 (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxaMide 1,2-Pyrrolidinedicarboxamide, N1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)- Alpelisib (BYL719) (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide BYL-719 BYL-719 (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide BYL-719(Alpelisib) (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)-pyridin-4-yl)thiazol-2-yl)pyrrolid ALPELISIB;BYL-719; BYL 719 CS-614 Alpelisib - NVP-BYL719 | BYL-719 100803 (2S)-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Alpelisib, 98%, a potent and selective PI3Kα inhibitor (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide ISO 9001：2015 REACH Alpelisib (BLY-719 (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidine BYL-719 Alpelisib Piqray Inhibitor,Phosphoinositide 3-kinase,PI3K,Alpelisib,inhibit,phosphorylation,p110α,cancer,BYL 719,antineoplastic,AKT,metastasis,mutant,BYL719,PIK3CA,breast Biopterin Impurity 2 (2S) - N1- [4-methyl-5- [2- (2,2,2-trifluoro-1,1-dimethylethyl) -4-pyridyl] -2-thiazolyl] -1,2-pyrrolidine dicarboxylamide 1217486-61-7 C19H22F3N5O2S Inhibitors Akt mTOR PI3K PI3K/Akt/mTOR Api API