SEDANOLIDE
- CAS No.
- 6415-59-4
- Chemical Name:
- SEDANOLIDE
- Synonyms
- SEDANOLIDE;neocnidilide;Neocindilide;cis-Sedanolide;trans-Sedanolide;fromceleryseedsoil;(3S)-3aβ,4,5,6-Tetrahyd;SEDANOLIDE FROM CELERY SEEDS OIL;SECO-ISOLARICIRESINOL DIGLUCOSIDE(SDG)(SH);3-BUTYL-3A,4,5,6-TETRAHYDRO-1(3H)-ISOBENZOFURANON
- CBNumber:
- CB5675984
- Molecular Formula:
- C12H18O2
- Molecular Weight:
- 194.27
- MDL Number:
- MFCD00171327
- MOL File:
- 6415-59-4.mol
| Melting point | 30～31℃ |
|---|---|
| Boiling point | 342.0±11.0 °C(Predicted) |
| Density | 1.03 |
| storage temp. | Store at -20°C, protect from light |
| solubility | insoluble in H2O; ≥52.8 mg/mL in EtOH; ≥6.65 mg/mL in DMSO |
| form | White to off-white solid. |
| Odor | at 100.00 %. herbal celery |
| Odor Type | herbal |
| LogP | 2.756 (est) |
| CAS DataBase Reference | 6415-59-4(CAS DataBase Reference) |
| FDA UNII | 9GXU758IFX |
SEDANOLIDE price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17166 | Sedanolide ≥95% | 6415-59-4 | 50mg | $89 | 2024-03-01 | Buy |
| Cayman Chemical | 17166 | Sedanolide ≥95% | 6415-59-4 | 100mg | $151 | 2024-03-01 | Buy |
| Cayman Chemical | 17166 | Sedanolide ≥95% | 6415-59-4 | 500mg | $622 | 2024-03-01 | Buy |
| Usbiological | 361887 | Trans-Sedanolide | 6415-59-4 | 10mg | $632 | 2021-12-16 | Buy |
| TRC | S241500 | Sedanolide | 6415-59-4 | 50mg | $70 | 2021-12-16 | Buy |
SEDANOLIDE Chemical Properties,Uses,Production
Uses
Sedanolide is a natural phthalide isolates from seed oil of Umbelliferae family. It induces the expression of glutathione S-transferase and reduces chemical induced carcinogenesis in mice.
Definition
ChEBI: Sedanolide is a member of 2-benzofurans.
Biological Activity
sedanolide is a natural compound produced in edible umbelliferous plants, such as celery seed oil [1].in hepg2 and caco-2 cells, treatment with sedanolide (7-500 μm) for 24h showed no effect on cell viability. in hepg2 cells cultured in sedanolide-free medium, sedanolide (500 μm) treatment for 72h decreased cell viability. pretreatment with sedanolide (100 μm) for 24 h and exposement to either h2o2 or tbooh did not exhibit statistically significant difference in viability from controls. in hepg2 following 24-h incubation with 500 μm sedanolide, a significant increase in dna strand breaks was observed. sedanolide did not modulate h2o2- and tbooh-induced dna damage. sedanolide was relatively nontoxic to cells in culture [1]. sedanolide (sn) possesses antioxidant effects. in human liver cancer (j5) cells, treatment with sedanolide suppressed j5 cell viability by inducing autophagy. sedanolide decreased protein expression levels of phosphoinositide 3-kinase (pi3k)-i, mammalian target of rapamycin (mtor) and akt and increased pi3k-iii, lc3-ii and beclin-1 protein levels. sedanolide increased the cytosolic phosphorylation of inhibitor of kappa b (iκb) and nuclear p65 and the dna-binding activity of nf-κb. sedanolide induced j5 cell autophagy by regulating pi3k, p53 and nf-κb autophagy-associated signaling pathways in j5 cells [2]. sedanolide (100 μg/ml) inhibited cyclooxygenases-1 and -2 at 250 pg/ml and blocked topoisomerase-i and-ii activity [3].
References
[1] woods j a, jewell c, o'brien n m. sedanolide, a natural phthalide from celery seed oil: effect on hydrogen peroxide and tert-butyl hydroperoxide-induced toxicity in hepg2 and caco-2 human cell lines[j]. in vitro & molecular toxicology: a journal of basic and applied research, 2001, 14(3): 233-240.
[2] hsieh s l, chen c t, wang j j, et al. sedanolide induces autophagy through the pi3k, p53 and nf-κb signaling pathways in human liver cancer cells[j]. international journal of oncology, 2015, 47(6): 2240-2246
[3] momin r a, nair m g. antioxidant, cyclooxygenase and topoisomerase inhibitory compounds from apium graveolens linn. seeds[j]. phytomedicine, 2002, 9(4): 312-318.
SEDANOLIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253 | jancyzheng@gcgreenpure.com | China | 952 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
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