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ChemicalBook >> CAS DataBase List >>2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE

2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE

2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE Structure
2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE structure
CAS No.
478482-75-6
Chemical Name:
2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE
Synonyms
TIBPO;GSK3β Inhibitor II;GSK-3 INHIBITOR II;GSK3.beta. Inhibitor II;GLYCOGEN SYNTHASE KINASE-3 INHIBITOR II;GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem;2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE;2-((3-Iodobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole;4-[5-[[(3-Iodophenyl)methyl]thio]-1,3,4-oxadiazol-2-yl]pyridine;2-[(3-iodophenyl)methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole
CBNumber:
CB2201711
Molecular Formula:
C14H10IN3OS
Molecular Weight:
395.22
MDL Number:
MFCD04974171
MOL File:
Mol file
Last updated:2023-09-04 15:51:00
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2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE Properties

Boiling point 532.6±60.0 °C(Predicted)
Density 1.79±0.1 g/cm3(Predicted)
storage temp. -20C
solubility ≤3mg/ml in DMSO;10mg/ml in dimethyl formamide
form Yellow solid
pka 0.97±0.10(Predicted)

2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 361541 GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem 478482-75-6 5mg $141 2021-12-16 Buy
Cayman Chemical 19077 GSK3β Inhibitor II ≥95% 478482-75-6 5mg $93 2024-03-01 Buy
Cayman Chemical 19077 GSK3β Inhibitor II ≥95% 478482-75-6 10mg $176 2024-03-01 Buy
ApexBio Technology C4599 GSK-3βInhibitorII 478482-75-6 10mg $198 2021-12-16 Buy
AK Scientific 9903CP GSK-3InhibitorII 478482-75-6 5mg $201 2021-12-16 Buy
Product number Packaging Price Buy
361541 5mg $141 Buy
19077 5mg $93 Buy
19077 10mg $176 Buy
C4599 10mg $198 Buy
9903CP 5mg $201 Buy

2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE Chemical Properties,Uses,Production

Definition

ChEBI: 2-[(3-iodophenyl)methylthio]-5-pyridin-4-yl-1,3,4-oxadiazole is an aryl sulfide.

Biological Activity

gsk-3β inhibitor ii is a gsk-3β inhibitor.glycogen synthase kinase-3 (gsk-3), a protein-serine kinase, is implicated in the hormonal control of various regulatory proteins. a number of substrates have been identified, which implicates gsk-3 in the regulation of several physiological processes. moreover, it has been reported that compounds that specifically inhibit gsk-3 activity may be useful in the treatment of diabetes.

in vitro

in a previous study, by using a virtual screening strategy based on a methodology derived from the cats molecular descriptor, a novel compound class including gsk-3β inhibitor ii with inhibitory activity against the gsk-3 enzyme was identified via scaffold hopping. gsk-3β inhibitor ii was found to be a potent inhibitor of gsk-3β with the ic50 value of 390 nm. however, gsk-3β inhibitor ii was not able to inhibit another gsk-3 isoform, gsk-3α [1]. another study found that gsk-3β inhibitor ii could block the functional regulation of p53 through inhibiting gsk-3β, decreasing mdm2 levels, and modulating mitochondrial p53 apoptotic signaling [2].

IC 50

390 nm for gsk-3β

References

[1] naerum, l. ,nrskov-lauritsen, l. and olesen, p.h. scaffold hopping and optimization towards libraries of glycogen synthase kinase-3 inhibitors. bioorg.med.chem.lett. 12(11), 1525-1528 (2002).
[2] watcharasit, p. ,bijur, g.n.,song, l., et al. glycogen synthase kinase-3beta (gsk3beta) binds to and promotes the actions of p53. j.biol.chem. 278(49), 49972-48879 (2003).

2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE Suppliers

Global( 30)Suppliers
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
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Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Aladdin Scientific 		58
Shanghai T&W Pharmaceutical Co., Ltd. 58
Shanghaizehan biopharma technology co., Ltd. 55
BOC Sciences 65
Shanghai EFE Biological Technology Co., Ltd. 58
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Shanghai Chaolan Chemical Technology Center 58
DC Chemicals 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58

2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE Spectrum

2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE(478482-75-6)1HNMR

478482-75-6(2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE)Related Search:

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TIBPO 2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE GLYCOGEN SYNTHASE KINASE-3 INHIBITOR II GSK-3 INHIBITOR II Pyridine, 4-[5-[[(3-iodophenyl)Methyl]thio]-1,3,4-oxadiazol-2-yl]- 4-[5-[[(3-Iodophenyl)methyl]thio]-1,3,4-oxadiazol-2-yl]pyridine GSK3.beta. Inhibitor II GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem GSK3β Inhibitor II 2-[(3-iodophenyl)methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole 2-((3-Iodobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole 478482-75-6