HOECHST 34580
- CAS No.
- 23555-00-2
- Chemical Name:
- HOECHST 34580
- Synonyms
- ProaMine;HOE 34580;HOECHST 34580;Hoechst 34580 (HOE 34580);2,50-bibenzimidazole, 20-[p-(dimethylamino)phenyl]-5-(4-methyl-1-piperazinyl)-;Benzenamine, N,N-dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]-;N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline;N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline
- CBNumber:
- CB5729663
- Molecular Formula:
- C27H29N7
- Molecular Weight:
- 451.57
- MDL Number:
- MFCD25541584
- MOL File:
- 23555-00-2.mol
| Melting point | >300℃ |
|---|---|
| Boiling point | 733.2±70.0 °C(Predicted) |
| Density | 1.280±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Soluble in dimethyl sulfoxide, water |
| form | powder |
| pka | 10.97±0.10, most acidic, temperature: 25 °C; 7.66 ± 0.42, most basic(at 25℃) |
| color | Yellow to green |
| λmax | 392nm |
| Biological Applications | Detecting malaria infected red blood cells,polynucleotides; nucleic acid amplification; nucleic acid sequencing |
HOECHST 34580 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Adipogen Life Sciences | CDX-B0094-M005 | Hoechst 34580 ≥98%(HPLC) | 23555-00-2 | 5mg | $59 | 2021-12-16 | Buy |
| ChemScene | CS-1303 | Hoechst 34580 99.84% | 23555-00-2 | 5mg | $72 | 2021-12-16 | Buy |
| ChemScene | CS-1303 | Hoechst 34580 99.84% | 23555-00-2 | 10mg | $108 | 2021-12-16 | Buy |
| ApexBio Technology | A3475 | Hoechst 34580 | 23555-00-2 | 25mg | $112 | 2021-12-16 | Buy |
| ChemScene | CS-1303 | Hoechst 34580 99.84% | 23555-00-2 | 50mg | $288 | 2021-12-16 | Buy |
HOECHST 34580 Chemical Properties,Uses,Production
Biological Activity
Hoechst 34580 (HOE 34580) is a cell-permeable blue fluorescent dye used to stain DNA and cell nuclei. It is also a good candidate for the treatment of Alzheimer's disease by inhibiting the formation of amyloid beta (Aβ) with an IC50 value of 0.86 μM.
in vitro
Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC 50 of 0.86±0.05 μM for Hoechst 34580. It is a good candidate for treating the Alzheimer's disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose- dependent manner. And the half-maximal concentration (IC 50 ) is examined. The IC 50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86 ±0.05 μM for Hoechst 34580.
target
| Target | Value |
| Aβ (Cell-free assay) | 0.86 μM |
HOECHST 34580 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2989 | 60 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3444 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |