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Midodrine hydrochloride

Midodrine hydrochloride Structure
Midodrine hydrochloride structure
CAS No.
3092-17-9
Chemical Name:
Midodrine hydrochloride
Synonyms
GUTRON;AMATINE;ST-1085;HIPERTAN;MIDODRINE;METLIGINE;PROAMATINE;MIDODRINE HCL;Prestwick_625;MIDODRINE HYDROCHLORIDE
CBNumber:
CB6117144
Molecular Formula:
C12H19ClN2O4
Molecular Weight:
290.74
MDL Number:
MFCD00079455
MOL File:
3092-17-9.mol
MSDS File:
SDS
Last updated:2023-11-21 10:35:13
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Midodrine hydrochloride Properties

Melting point 192-193°C
storage temp. -20°C Freezer
InChIKey MGCQZNBCJBRZDT-UHFFFAOYSA-N
CAS DataBase Reference 3092-17-9(CAS DataBase Reference)
FDA UNII 59JV96YTXV
ATC code C01CA17

Pharmacokinetic data

Protein binding Negligible
Excreted unchanged in urine 2%
Biological half-life 25 minutes (3 hours for active metabolite) / increased (9 for active metabolite)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  AB4343000
HS Code  29242990

Midodrine hydrochloride price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M8277 Midodrine hydrochloride analytical standard, for drug analysis 3092-17-9 1g $377 2024-03-01 Buy
Sigma-Aldrich 1443704 Midodrine hydrochloride United States Pharmacopeia (USP) Reference Standard 3092-17-9 200mg $436 2024-03-01 Buy
Sigma-Aldrich M8277 Midodrine hydrochloride analytical standard, for drug analysis 3092-17-9 50mg $114 2024-03-01 Buy
Usbiological M3895-06K Midodrine, Hydrochloride 3092-17-9 10mg $403 2021-12-16 Buy
American Custom Chemicals Corporation API0024416 MIDODRINE HYDROCHLORIDE 95.00% 3092-17-9 5MG $418 2021-12-16 Buy
Product number Packaging Price Buy
M8277 1g $377 Buy
1443704 200mg $436 Buy
M8277 50mg $114 Buy
M3895-06K 10mg $403 Buy
API0024416 5MG $418 Buy

Midodrine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

Originator

Gutron,Hormonchemie,W. Germany,1977

Uses

morphine antagonist

Uses

A phenylalkanolamine derivative which has been found to be effective in treating hypertensive conditions due to their long lasting blood pressure increasing effects

Definition

ChEBI: A hydrochloride resulting from the combination of equimolar amounts of midodrine and hydrogen chloride. Midodrine is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. The hydrochloride salt is used as a periph ral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.

Manufacturing Process

19.5 parts of carbobenzoxyglycine, 7.1 parts of triethylamine and 162 parts ofdry toluene are mixed with 11.2 parts of isovaleric acid chloride at 0°C toform the mixed anhydride and the mixture is agitated for two hours at 0°C.32.4 parts of 1-(2',5'-dimethoxyphenyl)-2-aminoethanol-(1) are then added,the mixture is agitated for four hours at a temperature between 0°C and+10°C and then left to stand overnight at that temperature. A thick crystalpaste forms. The reaction product is dissolved in 450 parts of ethyl acetateand 200 parts of water. The ethyl acetate solution is separated, washed withhydrochloric acid, sodium bicarbonate solution and water, dried over sodiumsulfate and inspissated. The inspissation residue is digested with 342 parts ofxylene, the required product crystallizing out. 34.9 parts of 1-(2',5'-dimethoxyphenyl)-2-(N-carbobenzoxyglycineamido)-ethanol-(1) are obtained.66.2 parts of 1-(2',5'-dimethoxyphenyl)-2-(N-carbobenzoxyglycineamido)-ethanol-(1) are hydrogenated in the presence of 6.6 parts of palladium carbon(10%) in 2,000 parts of glacial acetic acid. When no more hydrogen isabsorbed (3 mols of hydrogen are used), hydrogenation stops. The catalyst isremoved by suction and the equivalent quantity of hydrochloric acid in ethanolis added to the filtrate with agitation. During further agitation at roomtemperature 28.6 parts of crude 1-(2',5'-dimethoxyphenyl)-2-glycineamidoethanol-(1)hydrochloride crystallize, and are isolated andrecrystallized from water-methanol for purification. 22.1 parts of pure productare obtained with a melting point of 192°C to 193°C.
An alternative synthesis route is described by Kleeman and Engel.

brand name

Orvaten (UpsherSmith); Proamatine (Shire).

Therapeutic Function

Peripheral vasotonic, Antihypotensive

General Description

Midodrine is the N-glycyl prodrug ofthe selectiveα1-agonist desglymidodrine. Removal of theN-glycyl moiety from midodrine occurs readily in the liver aswell as throughout the body, presumably by amidases.Midodrine is orally active and represents another example ofa dimethoxy-β-phenylethylamine derivative that is used therapeuticallyfor its vasoconstrictor properties. Specifically, it isused in the treatment of symptomatic orthostatic hypotension.

Clinical Use

Treatment of orthostatic hypotension, including dialysis related hypotension

Drug interactions

Potentially hazardous interactions with other drugs
Adrenergic neurone blockers: midodrine antagonises hypotensive effect.
Anaesthetics: risk of arrhythmias if given with volatile anaesthetics.
Antidepressants: risk of arrhythmias and hypertension if given with tricyclic antidepressants, MAOIs and moclobemide.
Antihypertensives: antagonise hypertensive effect of midodrine; risk of severe hypertension if given with beta-blockers.
Dopaminergics: avoid with rasagiline and selegiline.
Other drugs which increase blood pressure: enhanced hypertensive effect.

Metabolism

Undergoes enzymatic hydrolysis in the systemic circulation to an active metabolite (desglymidodrine)

Midodrine hydrochloride Preparation Products And Raw materials

Raw materials

Isovaleryl chloride Hydrogen N-Carbobenzyloxyglycine ETHYLENEDIAMINE TETRAKIS(PROPOXYLATE-BLOCK-ETHOXYLATE) TETROL

Preparation Products

Midodrine hydrochloride Suppliers

Global( 134)Suppliers
Supplier Tel Email Country ProdList Advantage
Chengdu Aupone Pharmaceutical Co.Ltd.
+86-28-+86-28-87843998-6060-6060 +8618631098571 lijiaqi@aupone.com China 43 58
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
TianYuan Pharmaceutical CO.,LTD 		+86-755-23284190 13684996853 sales@tianpharm.com CHINA 304 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569265 +86-18612256290 1056@dideu.com China 3581 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
AFINE CHEMICALS LIMITED 		0571-85134551 info@afinechem.com CHINA 15377 58
Supplier Advantage
Chengdu Aupone Pharmaceutical Co.Ltd.
58
Hangzhou FandaChem Co.,Ltd. 		55
career henan chemical co 		58
TianYuan Pharmaceutical CO.,LTD 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Shaanxi Dideu Medichem Co. Ltd 		58
TargetMol Chemicals Inc. 		58
AFINE CHEMICALS LIMITED 		58

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View Lastest Price from Midodrine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Midodrine hydrochloride pictures 2023-02-04 Midodrine hydrochloride
3092-17-9
 US $0.00 / KG 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
Midodrine hydrochloride pictures 2021-07-20 Midodrine hydrochloride
3092-17-9
 US $0.00-0.00 / KG 1g 99% 2000tons Shaanxi Dideu Medichem Co. Ltd
Midodrine hydrochloride pictures 2021-07-02 Midodrine hydrochloride
3092-17-9
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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[+/-]-1-[2,5-DIMETHOXYPHENYL]-2-GLYCINAMIDOETHANOL HYDROCHLORIDE AMATINE METLIGINE HIPERTAN GUTRON 2-amino-n-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)-acetamidmonohydrochlo acetamide,2-amino-n-(beta-hydroxy-2,5-dimethoxyphenethyl)-,monohydrochloride, PROAMATINE MIDODRINE HCL MIDODRINE HYDROCHLORIDE MIDODRINE ST-1085 ST-1085, Amatine, Gutron, Hipertan, Metligine, ProAmatine, (±)-1-(2,5-dimethoxyphenyl)-2-glycinamidoethanol (+/-)-1-(2,5-Dimethoxyphenyl)-2-glycinamidoethanol hydrochloride Prestwick_625 Midodrine Hydrochloride (200 mg) 2-aMino-N-(2-(2,5-diMethoxyphenyl)-2-hydroxyethyl)acetaMide hydrochloride Midodrine hydrochloride, >=98% Midodrine Hydrochloride (1443704) Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-,monohydrochloride, (?±)- 3092-17-9 C12H18N2O4HCl C12H19ClN2O4 METI - MZ Analytical Standards Analytical Chromatography Product Catalog Alphabetic API Intermediates & Fine Chemicals Pharmaceuticals Isotopically Labeled Pharmaceutical Reference Standard VIVITROL