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ChemicalBook >> CAS DataBase List >> N,N-Dimethylacetamide


Outline Chemical Properties Incompatibility Penetration pathways First aid Protective measures Medical Care Test methods Storage Transport requirements Application Production method Category Toxicity grading Acute toxicity Stimulus data Explosive hazardous characteristics Flammability hazard characteristics Extinguishing agent Occupational standards

CAS No. 127-19-5
Chemical Name: N,N-Dimethylacetamide
Synonyms: DMAC;U-5954;nsc3138;SK 7176;NSC 3138;OmniPure?;CBC 510337;Hallucinogen;CH3CON(CH3)2;Acetic acid-di
CBNumber: CB8853004
Molecular Formula: C4H9NO
Formula Weight: 87.12
MOL File: 127-19-5.mol
N,N-Dimethylacetamide Property
Melting point : -20 °C
Boiling point : 164.5-166 °C(lit.)
density : 0.937 g/mL at 25 °C(lit.)
vapor density : 3.89 (vs air)
vapor pressure : 40 mm Hg ( 19.4 °C)
refractive index : n20/D 1.439(lit.)
Fp : 158 °F
storage temp. : 0-6°C
solubility : >1000g/l soluble
form : Liquid
color : Colorless to yellowish
PH: 4 (200g/l, H2O, 20℃)
explosive limit: 1.7-11.5%(V)
Water Solubility : miscible
Merck : 14,3227
BRN : 1737614
Stability:: Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference: 127-19-5(CAS DataBase Reference)
NIST Chemistry Reference: Acetamide, N,N-dimethyl-(127-19-5)
EPA Substance Registry System: Acetamide, N,N-dimethyl-(127-19-5)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : F,Xn,T
Risk Statements : 11-20/22-61-20/21-36
Safety Statements : 16-24-53-45-36-28-26
RIDADR : UN 1279 3/PG 2
WGK Germany : 3
RTECS : TX9625000
F : 3-10
TSCA : Yes
HS Code : 29241900
Hazardous Substances Data: 127-19-5(Hazardous Substances Data)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H227 Combustible liquid Flammable liquids Category 4 Warning P210, P280, P370+P378, P403+P235,P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger P260, P264, P270, P314, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to..…

N,N-Dimethylacetamide Chemical Properties,Usage,Production

N,N-dimethylacetamide dimethyl amine, also known as an acetyl group, an acetyl dimethylamine, referred to as the DMAC, which is a highly polar aprotic solvent, micro ammonia odor, very strong dissolving power, soluble wide, miscible with water, aromatics, esters, ketones, alcohols, ether, benzene and chloroform and other arbitrary and enable activation of molecular compounds. It is widely used as a solvent and a catalyst. The solvent, with high boiling point, flash point, thermal stability and chemical stability of the solvent, is used for polyacrylonitrile spinning solvent, synthetic resin and natural resins, formic acid vinyl ester resin, vinyl pyridine copolymer and aromatic carboxylic acid. The catalyst can be used in the process of urea heating to produce the reaction of cyanide, sodium halide and metal cyanide to produce the reaction of alkyl acetylene, organic halide and isocyanate. N,N-dimethylacetamide also can be used as electrolytic solvent and photography with coupler solvent, de paint agent, organic synthesis of raw materials, pesticide and pharmaceutical raw materials. Separation of styrene from C8 fraction, extraction, distillation, solvent, etc..
Invasive dangerous situation
Inhaled toxic (toxicity stronger than dimethylformamide), decomposition products may be absorbed through the skin, eye, skin and mucous membranes, which have a strong irritant. See "dimethylformamide." Combustible. Rat oral LD505.4ml/kg. The allowable concentration in air is US 10ppm (35mg/m3).
Chemical Properties
Transparent colorless liquid. The organic solvent can be mixed with any water, alcohol, ether, ester, benzene, chloroform, and aromatic compounds.
The N, N-Dimethylacetamide are incompatible wiyb carbon tetrachloride and other halogenated compounds. Unsaturated aliphatic compounds are soluble in this product, but saturated aliphatic solubility of the compound in this product is small. The solubility of hydrolysis product is small. But in the presence of acid, it can accelerate the hydrolysis. This product has good stability, and it does not decompose during distillation. With a strong base to form acetates and alkyl amines, in the presence of a proton, the alcohol can have solution when heated.
Penetration pathways
Steam inhalation, skin absorption, ingestion, contact with the eyes and skin.
The workers, who are often exposed to dimethyl acetamide, observed jaundice, liver damage, but in general it can be quickly restored. When someone with FDA uses it as anticancer drugs and large doses of oral symptoms, it can cause depression, lethargy, visual hallucinations. It may also occur heart, kidney and brain degeneration. DMA mouse embryo has toxic effects on the rabbit have teratogenic effects.
First aid
If such chemicals like splashed into the eyes, you should rinse with running water 15min immediately; if contact with skin, you should wash it immediately with plenty of water; if they are swallowed, you should be given medical attention, clothing with plenty of water, induce vomiting, gastric lavage. Do not induce vomiting with unconscious person. Instead, they should be sent to the hospital at once.
Protective measures
Workshop should be ventilated, confined to production equipment. At high vapor concentrations work place, you should use an organic vapor respirator or air supplied respirator, gloves and protective clothing to prevent absorption through the skin. Wear goggles to prevent splashing into the eyes. In the workplace with splashing or spills of this substance, you should be taken off the wet clothes immediately and thoroughly wash the contaminated surface of the skin. Distribute to workers clean clothes before going to work every day, and take a shower after work.
Medical Care
When the pre-employment and periodic medical examinations, we should pay special attention to the skin, the central nervous system, liver disease or liver function tests.
Test methods
Measured in the air: adsorption with silica, methanol and analyzed by gas chromatography.
Storage with iron costumes to prevent the mechanical damage. Store in a cool, dry place, avoid light exposure, away from any possible source of ignition.
Transport requirements
N,N-dimethylacetamide Department are toxic flammable liquids, adjustment shall be toxic substances provides storage and transportation. Transportation shall be marked "dangerous drugs" mark, and prevent the sun, impact, when handling, attention gently on the container.
Recommended methods of controlling waste incineration (incinerators shall have a scrubber or thermal means to reduce the discharge of NOx).
  • Used in organic synthesis, also used as solvents, catalysts, and paint removers.
  • DMAC is mainly used as synthetic fibers (acrylonitrile) and polyurethane spinning synthetic polyamide resin and a solvent, but also it is used for separating styrene from the C8 fraction extractive distillation solvent, and it is widely used in the aspects of polymer films, coatings and medicine. Currently it is used to synthesize a large number of antibiotics and pesticides in the pharmaceutical and pesticide. The catalyst can also be used for the reaction, electrolytic solvent, paint scavengers and various crystalline solvent adducts and complexes.
  • Used as the reaction solvent of pharmaceutical synthesis, synthetic fiber spinning solvents and synthetic resins, photographic chemicals chromogenic agent solvents, paints and other solvents, catalyst.
Production method
1. Acetic anhydride method dimethylamine and acetic anhydride have acylation reaction at 0-20 ℃, and then neutralized with low temperature liquid removing acetic, isolated from sodium acetate and Neutralization Solution and alkali washing, distillation, boiling range 164-166.5 DEG C fraction for the finished product. Material consumption fixed: acetic anhydride (95%) 1150kg/t, dimethylamine (40%) 1898kg/t.
2. Acetyl chloride method, by the reaction of dimethylamine and chloride, can also be prepared in dimethylacetamide. Compared with the process of the current domestic acetic anhydride process, it can reduce production costs, and improve economic efficiency.
3. Acetic acid method Fushun Research Institute of Chemical equipment using acetic acid and dimethylamine synthesis, and achieved good results. The process is characterized by the use of advanced catalytic distillation technology, strengthen reaction, reduce energy consumption, separation and product yield greatly improved, simplified the process. Compared to the synthesis process of this technology and two methylacetamide acetic anhydride methods, it can reduce production costs, improve economic benefits. China is currently more of people use it.
4. Study abroad Oxo trimethylamine and carbon monoxide carbonylation synthesis to produce N,N-dimethylacetamide approach. The reaction with iron, cobalt, nickel iodide or bromide as a catalyst.
Flammable liquids
Toxicity grading
Acute toxicity
Oral-rat LD50: 4300 mg/kg; Oral-Mouse LD50: 4620 mg/kg
Stimulus data
Skin-Rabbit 10 mg/24 hr mild; Eye-rabbit mild 100 mg
Explosive hazardous characteristics
Mixed with air can be explosive
Flammability hazard characteristics
In case of fire, high temperature, strong oxidants combustible; combustion emissions of toxic nitrogen oxide fumes.
Extinguishing agent
Foam, powder, carbon dioxide
Occupational standards
TLV-TWA 10 PPM (35 mg/cubic meter); STEL 15 PPM (50 mg/m3)
Chemical Properties
colourless liquid with a faint ammonia odour
ChEBI: A member of the class of acetamides that is acetamide in which the hydrogens attached to the N atom have been replaced by two methyl groups respectively. Metabolite observed in cancer metabolism.
General Description
A clear colorless liquid with a faint odor similar to ammonia. About the same density as water. Flash point 145°F. Vapors heavier than air. May by toxic by skin absorption. May irritate eyes and skin.
Air & Water Reactions
Water soluble.
Reactivity Profile
N,N-Dimethylacetamide is an amide. Incompatible with oxidizing agents and halogenated compounds. Exothermic reactions occur with carbon tetrachloride and hexachlorocyclohexane. N,N-Dimethylacetamide can react violently in the presence of iron. Special Hazards of Combustion Products: Emits carbon oxides, nitrogen oxides, and dimethylamine when heated to decomposition.
Health Hazard
Liquid causes mild irritation of eyes and skin. Ingestion causes depression, lethargy, confusion and disorientation, visual and auditory hallucinations, perceptual distortions, delusions, emotional detachment, and affective blunting.
Fire Hazard
N,N-Dimethylacetamide is combustible.
N,N-Dimethylacetamide Preparation Products And Raw materials
Raw materials
CARBON MONOXIDE Chemical equipment Sodium acetate trihydrate Acetyl chloride 5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide TRIMETHYLAMINE HYDROCHLORIDE Acetic acid glacial Bromide Dimethylamine
Preparation Products
1,2-Dichloropropane Molosultap 1-(5-NITRO-3-THIENYL)ETHAN-1-ONE 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL- Cefotaxime sodium 2-(1-HYDROXYLAMINOETHYL)-BENZOTHIOPHENE 2-Acetylbenzo[b]thiophene 3-(Benzofuran-2-yl)-3-oxopropanenitrile ,97% Fluoxetine 1-Naphthalenesulfonyl chloride 5-Acetylindole complex polystyrene high efficiency anticorrosion paint Pergolide 1,3-Dichloropropene Thiocyclam hydrogen oxalate Cefoperazone 6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR 2-ACETYL-3-AMINOTHIOPHENE 4-Hydroxyindole 4'-Phenoxyacetophenone Diphenylacetylene Phenformin 1-Chloro-2-propanol Flufenamic acid Cefdinir 2-Acetyl pyrrole Cefmenoxime 4-Methoxy-N,6-dimethyl-1,3,5-triazin-2-amine cis-DL-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid 4-Fluoroaniline main chain liquid crystalling polysiloxane polyurethane 2-Acetylbenzofuran CHROMONE-3-CARBOXALDEHYDE 1-METHYL-1H-IMIDAZOLE-5-CARBOXYLIC ACID 3-METHYLADENINE
N,N-Dimethylacetamide Suppliers      Global( 322)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Beijing Ouhe Technology Co., Ltd +86-10-4006331231;+86-10-51280831;+86-10-82967028
+86-10-82967029 China 10816 60
Hefei TNJ Chemical Industry Co.,Ltd. +86 (551) 65418684 65418696
+86 (551) 65418697 China 1944 62
Shanghai Macklin Biochemical Co.,Ltd. 15221275939
021-51821727 China 13254 55
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
86-21-63290778 86-21-63218885 China 9988 79
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 China 25125 65
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96831 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) China 40403 62
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 China 30314 84
TCI (Shanghai) Development Co., Ltd. 800-988-0390
021-67121385 China 22833 81
Beijing dtftchem Technology Co., Ltd. 13651141086; 86(10)60275028、60275820
86 (10) 60270825 China 1443 62
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