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Triprolidine hydrochloride

Triprolidine hydrochloride structure

CAS No.: 6138-79-0

Chemical Name:: Triprolidine hydrochloride

Synonyms: rate,stereoisomer;TRIPROLIDINE HCL USP;trans-TriprolidineHCl;Tripolidine Hydrochloride;Triprolidine hydrochloride;Triprolidine Hydrochlorise;TRIPROLIDINE HCL MONOHYDRATE;TRIPROLIDINEHYDROCHLORIDE,USP;Triprolidine hydrochloride (347);triprolidinesigmareferencestandard

CBNumber:: CB6232533

Molecular Formula:: C19H23ClN2

Molecular Weight:: 314.85

MDL Number:: MFCD00150574

MOL File:: 6138-79-0.mol

MSDS File:: SDS

Last updated:2023-05-25 18:01:14

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Triprolidine hydrochloride Properties

Melting point	115-120°C
storage temp.	2-8°C
solubility	alcohol: soluble1 in 1.5 of solvent
color	White to Off-White
Water Solubility	>=10 g/100 mL at 20 ºC
Merck	13,9817
Stability	Stable, but discolours in light. Incompatible with strong oxidizing agents.
LogP	4.223 (est)
FDA 21 CFR	341.12
CAS DataBase Reference	6138-79-0(CAS DataBase Reference)
FDA UNII	YAN7R5L890
EPA Substance Registry System	Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride, monohydrate, (E)- (6138-79-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Hazard Codes	Xn
Risk Statements	22-36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	UT7658000
HS Code	2933399090

Triprolidine hydrochloride price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T6764	Triprolidine hydrochloride ≥99%	6138-79-0	1g	$45.5	2024-03-01	Buy
Sigma-Aldrich	PHR2662	Triprolidine PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial	6138-79-0	500MG	$200	2024-03-01	Buy
Sigma-Aldrich	1696007	Triprolidine hydrochloride United States Pharmacopeia (USP) Reference Standard	6138-79-0	300mg	$436	2024-03-01	Buy
Sigma-Aldrich	BP347	Triprolidine hydrochloride British Pharmacopoeia (BP) Reference Standard	6138-79-0	100MG	$263	2023-01-07	Buy
Sigma-Aldrich	T-140	Triprolidine hydrochloride solution 1?mg/mL in methanol ((as free base)), certified reference material, ampule of 1?mL, Cerilliant?	6138-79-0	1ML	$88.7	2022-05-15	Buy

Product number	Packaging	Price	Buy
T6764	1g	$45.5	Buy
PHR2662	500MG	$200	Buy
1696007	300mg	$436	Buy
BP347	100MG	$263	Buy
T-140	1ML	$88.7	Buy

Triprolidine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

TRIPROLIDINE HYDROCHLORIDE is a white, crystalline powder.

Uses

TRIPROLIDINE HYDROCHLORIDE is used as bulk pharmaceutical (antihistaminic). Product Data Sheet

Uses

anticholinergic (opthalmic)

Uses

trans-Triprolidine Hydrochloride is a potent H1 receptor antagonist. Anti-histamines.

Definition

TRIPROLIDINE HYDROCHLORIDE is a hydrate that is the monohydrate form of triprolidine hydrochloride. A sedating antihistamine, it is used for the symptomatic relief of uticaria, rhinitis, and various pruritic skin disorders.

brand name

Actidil (GlaxoSmithKline); Myidyl (USl).

General Description

Triprolidine hydrochloride,(E)-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine monohydrochloridemonohydrate (Actidil), is a white crystalline powder with a slight, but unpleasant, odor. It is soluble inwater and in alcohol, and its solutions are alkaline to litmus.
The antihistaminic activity is confined mainly to the geometricisomer in which the pyrrolidinomethyl group is transto the 2-pyridyl group. Pharmacological studies confirm thehigh activity of triprolidine and the superiority of (E) overcorresponding (Z) isomers as H1-antihistamines. At guineapig ileum sites, the affinity of triprolidine for H-receptorswas more than 1,000 times the affinity of its (Z) diasteromer.The relative potency of triprolidine is of the same orderas that of dexchlorpheniramine. The peak effect occursabout 3.5 hours after oral administration, and the duration ofeffect is about 12 hours.

General Description

Odorless white crystalline powder. Bitter taste.

Air & Water Reactions

Water soluble.

Reactivity Profile

Triprolidine hydrochloride discolors on exposure to light.

Health Hazard

SYMPTOMS: Symptoms of exposure to Triprolidine hydrochloride may include depression to stimulation of the central nervous system, dry mouth, fixed dilated pupils, flushing, hallucinations, convulsions, urinary retention, cardiac arrhythmias and coma. Other symptoms may include excitability, drowsiness, nervousness, dizziness, high fever and sleeplessness. It can also cause sedation. It may also cause local anesthesia, dryness of the throat and nose and abdominal pain with vomiting or diarrhea.

Fire Hazard

Flash point data for Triprolidine hydrochloride are not available; however, Triprolidine hydrochloride is probably combustible.

Biological Activity

Potent H 1 receptor antagonist.

Triprolidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Triprolidine hydrochloride Suppliers

Global( 160)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	1056@dideu.com	China	3581	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9320	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850 +86-13986145403	info@fortunachem.com	China	5988	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9339	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	20356	58

Supplier	Advantage
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
TargetMol Chemicals Inc.	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Wuhan Fortuna Chemical Co., Ltd	58
Baoji Guokang Bio-Technology Co., Ltd.	58
CD Chemical Group Limited	58

View Lastest Price from Triprolidine hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-09-08	Triprolidine hydrochloride 6138-79-0	US $0.00 / KG Ton	1KG Ton	USP4398%+	2 tons/month	Zhuhai Hairuide Bioscience and Technology Co., Ltd
2021-09-29	Triprolidine hydrochloride 6138-79-0	US $0.00-0.00 / Kg/Drum	1KG	98%-101%	100KG	WUHAN FORTUNA CHEMICAL CO., LTD
2021-07-20	Triprolidine hydrochloride 6138-79-0	US $1.00-1.00 / KG	1g	99%	50tons	Shaanxi Dideu Medichem Co. Ltd

Triprolidine hydrochloride
6138-79-0
US $0.00 / KG Ton
USP4398%+
Zhuhai Hairuide Bioscience and Technology Co., Ltd

Triprolidine hydrochloride
6138-79-0
US $0.00-0.00 / Kg/Drum
98%-101%
WUHAN FORTUNA CHEMICAL CO., LTD

Triprolidine hydrochloride
6138-79-0
US $1.00-1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

Triprolidine hydrochloride Spectrum

Triprolidine hydrochloride(6138-79-0)IR

6138-79-0(Triprolidine hydrochloride)Related Search:

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CALAMINE ALPHA,P-DIMETHYLSTYRENE TRANS-TRIPROLIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE METHYL-2-PYRROLIDONE

TRIPOLIDINE Triprolidine hydrochloride TRIPROLIDINE HYDROCHLORIDE Z-ISOMER (100 MG)

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Triprolidine Hydrochloride (500 mg) Triprolidine Hydrochloride (300 mg) TRIPROLIDINE HYDROCHLORIDE MONOHYDRATE pyridine,2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-,monohydrochloride,monohyd Pyridine,2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]-,monohydrochloride,monohydrate,stereoisomer rate,stereoisomer triprolidinesigmareferencestandard Pyridine, 2-(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl-, monohydrochloride, monohydrate TRIPROLIDINEHYDROCHLORIDE,USP 2-[(1E)-1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]pyridine hydrochloride monohydrate Tripolidine Hydrochloride TRIPROLIDINE HCL USP TRIPROLIDINE HCL MONOHYDRATE trans-TriprolidineHCl (E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride, trans-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride trans-1-(2-pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene hydrochloride monohydrate trans-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride monohydrate (E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride 2-(1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)pyridine monohydrochloride Triprolidine hydrochloride 2-[(E)-1-(4-Methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine hydrate hydrochloride 2-[1-(4-Methylphenyl)-3-(2,3,4,5-tetrahydropyrrol-1-yl)prop-1-enyl]pyridine chloride hydrate Triprolidine hydrochloride,(E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride, trans-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride Triprolidine Hydrochlorise 2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop1-en-1-yl]pyridine hydrate hydrochloride Triprolidine hydrochloride USP/EP/BP (E)-2-(3-(Pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine hydrochloride hydrate Triprolidine hydrochloride (347) Triprolidine Hydrochloride (1696007) 6138-79-0 C19H22N2ClHH2O C19H23N2ClH2O C19H22N2HClH2O MYRDRIACYL Bulk Pharmaceuticals