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1-Methyl-2-pyrrolidinone

Chemical Properties Uses

CAS No. 872-50-4
Chemical Name: 1-Methyl-2-pyrrolidinone
Synonyms: NMP;NMP-T;0131;NMP-EL;N-0131;M-Pyrol;gsolex 1;m-Pyrrole;AgsolEx 1;M-PYROL(R)
CBNumber: CB2402488
Molecular Formula: C5H9NO
Formula Weight: 99.13
MOL File: 872-50-4.mol
1-Methyl-2-pyrrolidinone Property
Melting point : −24 °C(lit.)
Boiling point : 202 °C(lit.)
density : 1.028 g/mL at 25 °C(lit.)
vapor density : 3.4 (vs air)
vapor pressure : 0.29 mm Hg ( 20 °C)
refractive index : n20/D 1.479
Fp : 187 °F
storage temp. : 2-8°C
solubility : ethanol: miscible0.1ML/mL, clear, colorless (10%, v/v)
form : Liquid
color : ≤20(APHA)
PH: 8.5-10.0 (100g/l, H2O, 20℃)
explosive limit: 1.3-9.5%(V)
Water Solubility : >=10 g/100 mL at 20 ºC
Sensitive : Hygroscopic
Merck : 14,6117
BRN : 106420
Stability:: Stable, but decomposes upon exposure to light. Combustible. Incompatible with strong oxidizing agents, strong acids, reducing agents, bases.
CAS DataBase Reference: 872-50-4(CAS DataBase Reference)
NIST Chemistry Reference: 2-Pyrrolidinone, 1-methyl-(872-50-4)
EPA Substance Registry System: 2-Pyrrolidinone, 1-methyl-(872-50-4)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : T,Xi
Risk Statements : 45-65-36/38-36/37/38-61-10-46
Safety Statements : 41-45-53-62-26
RIDADR : UN 1268 3/PG 3
WGK Germany : 1
RTECS : UY5790000
F : 3-8-10
TSCA : Y
Hazardous Substances Data: 872-50-4(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H227 Combustible liquid Flammable liquids Category 4 Warning P210, P280, P370+P378, P403+P235,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
Precautionary statements:
P201 Obtain special instructions before use.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.

1-Methyl-2-pyrrolidinone Chemical Properties,Usage,Production

Chemical Properties
1-Methyl-2-pyrrolidinone (NMP) has a molecular formula of C5H9NO, and it is a colorless to light yellow transparent liquid with a slight ammonia odor. Its boiling point is 204℃, flash point is 91℃, chroma HaZen≤25, refractive index N20D 1.468-1.471, density is 1.032-1.035. It is miscible in water at any ratio, it is soluble in ethanol, acetone, esters, halogenated hydrocarbons, aromatic hydrocarbons and other organic solvents, and it can completely mix with practically all solvents. It is strongly hygroscopic, chemically stable, not corrosive towards carbon steel and aluminum, and slightly corrosive to copper. It has low adhesiveness, strong chemical and thermal stability, high polarity, and low volatility. This product is slightly toxic, and its permitted concentration limit in air is 100PPM.
Uses
NMP is a polar aprotic solvent that has the advantages of low toxicity, high boiling point, outstanding solvency, strong selectivity and good stability. It is widely used in purification of aromatic hydrocarbon extraction, acetylene, olefins, and diolefins. It is used as a polyvinylidene fluoride solvent and electrode auxiliary material for lithium ion batteries. It is used in gas desulfurization, lubricating oil refining, lubricating oil antifreeze, olefin extraction, and as a solvent for insoluble engineering plastics polymerization. It can be used in herbicide, to clean insulation materials, semiconductor industry precision instruments and circuit boards, to recycle PVC exhaust, as a detergent, dye supplement and dispersing agent. It is used in mediums for polymerization reactions such as engineering plastics and aramid fiber. It also has pharmaceutical uses. It is an excellent solvent, widely used in aromatics extraction, lubricating oil refining, acetylene enrichment, butadiene separation and synthesis gas desulfurization. It is used in industrial cleaning, and it serves as a solvent for production of pesticides, engineering plastics, coatings, synthetic fibers, and integrated circuits. It can also be used as an industrial cleanser, dispersant, dye, lubricant and antifreeze.
Chemical Properties
colourless or light yellow liquid with an amine odour
Uses
high purity grade for ICP-MS detection
Uses
It is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts.
Uses
For peptide synthesis
Uses
Used as solvent.
Definition
ChEBI: A member of the class of pyrrolidine-2-ones that is pyrrolidin-2-one in which the hydrogen attached to the nitrogen is replaced by a methyl group.
General Description
A clear colorless liquid with a "fishlike" odor. Denser than water. Flash point 199°F. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion.
Air & Water Reactions
Soluble in water.
Reactivity Profile
This amine is a very mild chemical base. 1-Methyl-2-pyrrolidinone does tend to neutralize acids to form salts plus water. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Health Hazard
Inhalation of hot vapors can irritate nose and throat. Ingestion causes irritation of mouth and stomach. Contact with eyes causes irritation. Repeated and prolonged skin contact produces a mild, transient irritation.
Fire Hazard
Special Hazards of Combustion Products: Toxic oxides of nitrogen may be formed in fire.
1-Methyl-2-pyrrolidinone Preparation Products And Raw materials
Raw materials
Acetone Methylamine Butyramide gamma-Butyrolactone
Preparation Products
4-(Trifluoromethyl)nicotinic acid 1-BENZOFURAN-5-CARBONITRILE Trimethylsilyl cyanide 3,5-DIMETHOXYPHENYLACETIC ACID 2-(DIPHENYLPHOSPHINO)ETHYLTRIETHOXYSILANE 4-Aminobutyric acid 3-AMINO-2-FLUORO-4-PICOLINE 5-(Trifluoromethyl)pyridine-2-carboxylic acid 1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine C-(1H-INDOL-5-YL)-METHYLAMINE Vat Orange 9 ethyl 2-(4-chloroquinazolin-7-yloxy)acetate THIOPHENE-2-THIOCARBOXAMIDE 5-Cyanoindole 3-Amino-6-chloropyridine-2-carboxylic acid 3-Amino-2-pyridinecarbonitrile 2-Furonitrile 1-(3-AMINOPROPYL)-2-PYRROLIDINONE 2-Chloro-6-trifluoromethylnicotinic acid 6-chloro-1H-indazol-3-amine 4-DIMETHYLAMINOBUTYRIC ACID HYDROCHLORIDE 2-Trifluoromethyl-5-bromopyridine 2-(TRIFLUOROMETHYL)-4-ISOCYANATOPYRIDINE 2-Trifluoromethyl-6-pyridinecarboxylic acid 6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE 2-(TRIFLUOROMETHYL)-PYRIDINE-4-CARBOXALDEHYDE 4-(PYRROLIDIN-1-YLMETHYL)BENZENEBORONIC ACID, PINACOL ESTER 97%1-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZYL]PYRROLIDINE
1-Methyl-2-pyrrolidinone Suppliers      Global( 423)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd. 0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3230 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96831 76
Tianjin Zhongxin Chemtech Co., Ltd. 86(0)22-89880739
86(0)22-89880739 ext 8030 / 86-22-66880086 sales@tjzxchem.com China 554 60
Chengdu RunZeBenTu Chemical Co., Ltd 13096311329 028-88469284 qq:616445927
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Hefei TNJ Chemical Industry Co.,Ltd. +86 (551) 65418684 65418696
+86 (551) 65418697 info@tnjchem.com China 1944 62
Ring Specialty Chemicals Inc. +1 416 493 6870
+1 416 499 9759 info@ringchemicals.com Canada 52 58
Shanghai XiZhi Chemical Co., Ltd. 021-69005855
021-69005955 xizhichem@163.com China 4254 55
Shanghai Xilong Biochemical Technology Co., Ltd. 021-52907766-8042
021-52906523 order@drmaolab.com China 10070 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
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Aikon International Limited 025-66151770,13813800073//qq:2850281386
lwan@aikonchem.com China 10222 58
 
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