ChemicalBook >> CAS DataBase List >>4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE

4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE

4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE structure

CAS No.: 327036-89-5

Chemical Name:: 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE

Synonyms: CS-568;NP 01139;TDZD-8/TDZD8;TDZD-8, >=98%;TDZD-8 (NP-01139);GSK-3β Inhibitor I;GSK-3InhibitorI,TDZD-8;TDZD-8;TDZD 8;TDZD8;NP 01139;TDZD8; TDZD 8;GSK-3Β) INHIBITOR I; NP 01139;GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem

CBNumber:: CB7501586

Molecular Formula:: C10H10N2O2S

Molecular Weight:: 222.26

MDL Number:: MFCD04973552

MOL File:: 327036-89-5.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE Properties

Melting point	63-64.4 °C
Boiling point	335.5±35.0 °C(Predicted)
Density	1.375±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 18 mg/mL
pka	-2.08±0.20(Predicted)
form	needles
color	white

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS08

Signal word

Danger

Hazard statements

H334

Precautionary statements

P261-P342+P311

Hazard Codes

Risk Statements

Safety Statements

36/37

WGK Germany

HS Code

2934999090

NFPA 704

	0
2		0

4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE price More Price(50)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T8325	TDZD-8 ≥98% (HPLC), needles	327036-89-5	5mg	$179	2024-03-01	Buy
Sigma-Aldrich	361540	GSK-3β Inhibitor I	327036-89-5	5mg	$144	2024-03-01	Buy
TCI Chemical	B4436	4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione >98.0%(HPLC)	327036-89-5	5mg	$98	2024-03-01	Buy
TCI Chemical	B4436	4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione >98.0%(HPLC)	327036-89-5	25mg	$294	2024-03-01	Buy
Cayman Chemical	16287	TDZD-8 ≥98%	327036-89-5	5mg	$61	2024-03-01	Buy

Product number	Packaging	Price	Buy
T8325	5mg	$179	Buy
361540	5mg	$144	Buy
B4436	5mg	$98	Buy
B4436	25mg	$294	Buy
16287	5mg	$61	Buy

4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.

Uses

Glycogen Synthase Kinase-3? is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selectiv

Definition

ChEBI: TDZD-8 is a member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a methyl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta). An experimental compound which was being developed for the potential treatment of Alzheimer's disease. It has a role as an EC 2.7.11.26 (tau-protein kinase) inhibitor, an apoptosis inducer, an antineoplastic agent, a neuroprotective agent and an anti-inflammatory agent. It is a thiadiazolidine and a member of benzenes.

General Description

A cell-permeable, thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP-competitive inhibitor of GSK-3β (IC₅₀ = 2 μM). Inhibits Flt-3 and PKC activities (IC₅₀ = 673 nM and 1.4-5.5 μM, respectively). Does not significantly affect the activities of Cdk1/cyclin B, CK-II, PKA, or PKC (IC₅₀ >100 μM). Shown to inhibit collagen- and thrombin-induced platelet aggregation.

Biological Activity

tdzd-8 is an inhibitor of glycogen synthase kinase-3β (gsk-3β) with ic50 value of 1.4μm [1].tdzd-8 is a potent inhibitor of gsk-3β. it is found to act as a noncompetitive inhibitor of atp binding. tdzd-8 is selective against gsk-3β over other protein kinases including pka, casein kinase ii and cyclin dependent kinase 1 (cdk-1/cyclin b). however, it is also reported that tdzd-8 can inhibit the protein kinase c isoforms pkcβi and pkcδ with ic50 values of 1.4μm and 1.1μm, respectively [1, 2].in cellular assay, tdzd-8 is found to decrease pdt-induced necrosis of neurons and decrease pdt-induced apoptosis of glial cells through inhibiting gsk-3β as well as pkc. besides that, tdzd-8 also has anti-leukemia activity in many primary human leukemia cells. it is probably due to its inhibition of pkc and flt3 [3].

Biochem/physiol Actions

Primary TargetGsk-3β

storage

Store at -20°C

References

[1] komandirov m a, knyazeva e a, fedorenko y p, et al. on the role of phosphatidylinositol 3-kinase, protein kinase b/akt, and glycogen synthase kinase-3β in photodynamic injury of crayfish neurons and glial cells. journal of molecular neuroscience, 2011, 45(2): 229-235.
[2] martinez a, alonso m, castro a, et al. first non-atp competitive glycogen synthase kinase 3 β (gsk-3β) inhibitors: thiadiazolidinones (tdzd) as potential drugs for the treatment of alzheimer's disease. journal of medicinal chemistry, 2002, 45(6): 1292-1299.
[3] guzman m l, li x, corbett c a, et al. rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1, 2, 4-thiadiazolidine, 3, 5 dione (tdzd-8). blood, 2007, 110(13): 4436-4444.

4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE Preparation Products And Raw materials

Raw materials

Preparation Products

4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE Suppliers

Global( 131)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21149	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58

View Lastest Price from 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE 327036-89-5	US $2.00 / kg	1kg	99%	100kg	Career Henan Chemical Co

4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
327036-89-5
US $2.00 / kg
99%
Career Henan Chemical Co

4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE Spectrum

4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE(327036-89-5)¹HNMR

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TDZD-8 TD 139 MANZAMINE A

1of4

GSK-3InhibitorI,TDZD-8 NP 01139 1,2,4-Thiadiazolidine-3,5-dione,2-Methyl-4-(phenylMethyl)- TDZD-8/TDZD8 4-Benzyl-2-methyl-[1,2,4]thiadiazolidine-3,5-dione TDZD-8 TDZD-8, >=98% TDZD-8;TDZD 8;TDZD8;NP 01139 2-Methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem CS-568 TDZD8; TDZD 8;GSK-3Β) INHIBITOR I; NP 01139 TDZD-8 (NP-01139) GSK-3β Inhibitor I inhibit,TDZD8,Inhibitor,TDZD 8,NP01139,GSK-3,TDZD-8,Glycogen synthase kinase 3,NP-01139,Glycogen synthase kinase-3 327036-89-5 Amines Aromatics Sulfur & Selenium Compounds Other Enzyme Inhibitors and Activators. Inhibitors Akt mTOR PI3K