Cefmenoxime
- CAS No.
- 65085-01-0
- Chemical Name:
- Cefmenoxime
- Synonyms
- CMX;SCE 1365;AB 50912;CEFMENOXIME;Cefotaxime Isomer;Cefmenoxime USP/EP/BP;7β-[[(Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazole-5-yl)thio]methyl]cepham-3-ene-4-carboxylic acid;(6R,7R)-7-[[(Z)-(2-Aminothiazol-4-yl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;(6R,7R)-7α-[2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetylamino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;[6R-[6α,7β(Z)]]-7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-y1)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oet-2-ene-2-carboxylic acid
- CBNumber:
- CB7771510
- Molecular Formula:
- C16H17N9O5S3
- Molecular Weight:
- 511.56
- MDL Number:
- MFCD00864851
- MOL File:
- 65085-01-0.mol
- MSDS File:
- SDS
Density | 1.96±0.1 g/cm3(Predicted) |
---|---|
pka | 2.61±0.50(Predicted) |
CAS DataBase Reference | 65085-01-0(CAS DataBase Reference) |
FDA UNII | KBZ4844CXN |
ATC code | J01DD05 |
Cefmenoxime price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | C242838 | Cefmenoxime | 65085-01-0 | 10mg | $580 | 2021-12-16 | Buy |
TRC | C242838 | Cefmenoxime | 65085-01-0 | 25mg | $1155 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0007249 | CEFMENOXIME 95.00% | 65085-01-0 | 5G | $909.56 | 2021-12-16 | Buy |
AHH | MT-49073 | Cefmenoxime 98% | 65085-01-0 | 0.1g | $910 | 2021-12-16 | Buy |
AvaChem | 2848 | Cefmenoxime | 65085-01-0 | 25mg | $55 | 2021-12-16 | Buy |
Cefmenoxime Chemical Properties,Uses,Production
Originator
Tacef,Takeda,W. Germany,1983
Uses
Antibacterial.
Uses
Cefmenoxime (cas# 65085-01-0) is a compound useful in organic synthesis.
Definition
ChEBI: A third-generation cephalosporin antibiotic, bearing a 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino group at the 7beta-position and a [(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl group at the 3-position.
Manufacturing Process
7β-[α-Methoxyimino-α-(2-aminothiazol-4-yl)acetamido]cephalosporanicacid trifluoroacetic acid salt is dissolved in a solution of 272 mg of 1-methyl-5- mercapto-1H-tetrazole, 555 mg of sodium bicarbonate and 68 mg of triethylbenzylammonium bromide in 10 ml of water. The solution is heated at 60°C in nitrogen atmosphere for 6 hours. After cooling, the reaction solution is passed through a column of Amberlite XAD-2 and eluted with water and then with 2.5% ethanol. The procedure yields sodium 7β-[α-methoxyimino-α- (2-aminothiazol-4-yl)acetamido]-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3- cephem-4-carboxylate, MP 174°C to 175°C (decomposition).
brand name
Cefmax (TAP).
Therapeutic Function
Antibacterial
Antimicrobial activity
A semisynthetic cephalosporin supplied as the hydrochloride.
Its activity is very similar to that of cefotaxime. A
500 mg intramuscular injection achieves a plasma concentration
of 15 mg/L after 40 min. A concentration of 200 mg/L is
attained after intravenous administration of 1 g. The plasma
half-life is c. 1 h. Around 77% is protein bound. Probenecid
increases peak plasma levels and extends the plasma half-life
to 1.8 h. Therapeutic concentrations are achieved in CSF.
There is a degradation product with a long half-life (around
40 h), but 80–92% of the drug is recovered unchanged from
the urine. In patients with renal insufficiency, no significant
relation was found between creatinine clearance and peak
serum concentrations but there was a linear relationship
with plasma half-life and total body clearance. About 10%
of the dose appears in the feces, mostly extensively degraded,
possibly
by the fecal flora.
Toxicity, side effects and clinical use are those common to
group 4 cephalosporins.
Cefmenoxime Preparation Products And Raw materials
Raw materials
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Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12446 | 58 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8820 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29822 | 58 |
Hebei Runbin Biotechnology Co. LTD | 13180553332 | 2179877681@qq.com | CHINA | 996 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Hebei Henghe Import and Export Trading Co. LTD | +8618032935937 18032916000 | demi@hbtycoon.com | CHINA | 449 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 8032 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15394 | 58 |
View Lastest Price from Cefmenoxime manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-03-31 | Cefmenoxime
65085-01-0
|
US $30.00-20.00 / kg | 1kg | 99% | 2000000 | Shanghai Chinqesen Biotechnology Co., Ltd. | ||
2023-06-20 | Cefmenoxime
65085-01-0
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | ||
2021-02-02 | Cefmenoxime
65085-01-0
|
US $1.00 / PCS | 1KG | 99% | 10mt | Hebei Guanlang Biotechnology Co., Ltd. |
- Cefmenoxime
65085-01-0
- US $30.00-20.00 / kg
- 99%
- Shanghai Chinqesen Biotechnology Co., Ltd.
- Cefmenoxime
65085-01-0
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
- Cefmenoxime
65085-01-0
- US $1.00 / PCS
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
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