3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE
- CAS No.
- 19881-70-0
- Chemical Name:
- 3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE
- Synonyms
- 104523;Windorphen;SALOR-INT L161004-1EA;Windorphen >=98% (HPLC);Windorphen - CAS 19881-70-0 - Calbiochem;(Z)-3-chloro-2,3-bis(4-methoxyphenyl)acrolein;3-CHLORO-2,3-DI(4-METHOXYPHENYL)ACRYLALDEHYDE;3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE;(Z)-3-chloro-2,3-bis(4-methoxyphenyl)prop-2-enal;(Z)-3-chloro-2,3-bis(4-Methoxyphenyl)acrylaldehyde
- CBNumber:
- CB8372871
- Molecular Formula:
- C17H15ClO3
- Molecular Weight:
- 302.75
- MDL Number:
- MFCD26940341
- MOL File:
- 19881-70-0.mol
- MSDS File:
- SDS
3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.09164 | Windorphen - CAS 19881-70-0 - Calbiochem | 19881-70-0 | 25mg | $225 | 2023-01-07 | Buy |
| Sigma-Aldrich | SML0899 | Windorphen ≥98% (HPLC) | 19881-70-0 | 5mg | $111 | 2022-05-15 | Buy |
| TRC | W498903 | Windorphen | 19881-70-0 | 500g | $360 | 2021-12-16 | Buy |
| Matrix Scientific | 045974 | 3-Chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde >95% | 19881-70-0 | 5g | $500 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC136063 | 3-Chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde | 19881-70-0 | 5G | $578 | 2021-12-16 | Buy |
3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE Chemical Properties,Uses,Production
Uses
Windorphen is a selective inhibitor of p300 histone acetyltransferase, a coactivator that associates with?β-catenin,?blocking the Wnt signal required for ventral development.
Biological Activity
windorphen is a wnt inhibitor that selectively abrogates the wnt signaling for ventral development.wnt protein is a family of signaling proteins that interacts on the wnt/β-catenin pathways during embryotic development, cell proliferation, migration and adult tissue homeostasis.in canonical wnt/β-catenin reporter cell line stf293, windorphen dose-dependently inhibits wnt3a-inducible topflash-luciferase activity (ic50 of 1.5 mm). in human colon adenocarcinomasw480 cells with defective apc gene that constitutively activates wnt signaling, 72 h treatment of windorphen causes a wide spread apoptosis. [1]in zebrafish embryos, windorphen leads to apparent expansion of the dorsal markers (pax2.1) and marker of rhombomeres 3 and 5 at the six-somite stage (krox0). windorphen selectively inhibits wnt signaling in ventral and lateral regions of the 50% epiboly stage embryo (5.3 hpf). in addition, windoprhen treatment rescues the telencephalon/eye phenotype in the mbl mutant zebrafish (i.e. a defective axin1/β-catenin destruction complex causes abnormal activation of wnt signaling and the loss of telencephalon and eyes.) [1]
References
1. hao j, ao a, zhou l et al. selective small molecule targeting β-catenin function discovered by invivo chemical genetic screen. cell rep. 2013 sep 12;4(5):898-904.
3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 021-61259108 18621169109 | market03@meryer.com | China | 40240 | 62 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35906 | 56 |
| ChemShuttle, Inc. | 0510-83588313-802 18800520310; | sales@chemshuttle.com | China | 3062 | 62 |
| Wuhan Kaymke Chemical Co., Ltd., | 027-87342388 18086026008 | sales@kaymke.com | China | 4123 | 55 |