Scopolamine butylbromide
- CAS No.
- 149-64-4
- Chemical Name:
- Scopolamine butylbromide
- Synonyms
- HYOSCINE BUTYLBROMIDE;buscopan;HYOSCINE N-BUTYL BROMIDE;(1S,2R,4S,5S)-9-butyl-7-[(3-hydroxy-2-phenylpropanoyl)oxy]-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane bromide;scobro;buscol;joscine;donopon;scobron;Stibron
- CBNumber:
- CB9126868
- Molecular Formula:
- C21H30BrNO4
- Molecular Weight:
- 440.37
- MDL Number:
- MFCD00078561
- MOL File:
- 149-64-4.mol
- MSDS File:
- SDS
Melting point | 142-1440C |
---|---|
alpha | D20 -20.8° (c = 3 in water) |
storage temp. | 2-8°C |
solubility | H2O: 50 mg/mL |
form | powder |
color | white |
optical activity | [α]25/D 20.8°, c = 3 in H2O(lit.) |
CAS DataBase Reference | 149-64-4(CAS DataBase Reference) |
FDA UNII | 0GH9JX37C8 |
NCI Drug Dictionary | butylscopolamine bromide |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302+H332 | |||||||||
Precautionary statements | P261-P264-P270-P271-P301+P312-P304+P340+P312 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | YM3500000 | |||||||||
Toxicity | LD50 in mice (mg/kg): 15.6 i.v.; 74 i.p.; 570 s.c.; 3000 orally (Stockhaus, Wick) | |||||||||
NFPA 704 |
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Scopolamine butylbromide price More Price(27)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | S7882 | (?)-Scopolamine N-butyl bromide ≥98% (TLC), powder | 149-64-4 | 1g | $54.7 | 2024-03-01 | Buy |
Sigma-Aldrich | S7882 | (?)-Scopolamine N-butyl bromide ≥98% (TLC), powder | 149-64-4 | 5g | $171 | 2024-03-01 | Buy |
Sigma-Aldrich | BP198 | Hyoscine butylbromide British Pharmacopoeia (BP) Reference Standard | 149-64-4 | 100MG | $229 | 2024-03-01 | Buy |
Cayman Chemical | 27223 | Scopolamine N-butyl (bromide) | 149-64-4 | 1g | $44 | 2024-03-01 | Buy |
Cayman Chemical | 27223 | Scopolamine N-butyl (bromide) | 149-64-4 | 10g | $299 | 2024-03-01 | Buy |
Scopolamine butylbromide Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Originator
Butylscopolamine,China Pharm
Uses
(?)-Scopolamine N-butyl bromide was used as standard in designing a procedure for quantification of compounds using CE-MS.8
Uses
Anticholinergic. Antispasmodic
Definition
ChEBI: Butylscopolamine bromide is an organic bromide salt of butylscopolamine. It is an antispasmodic drug which can relieve painful stomach cramps (including those linked with irritable bowel syndrome), bladder and menstrual cramps. It has a role as a muscarinic antagonist and an antispasmodic drug. It is an organic bromide salt and a quaternary ammonium salt. It contains a butylscopolamine.
Manufacturing Process
1300 g of scopolamine base and 350 g of n-butylbromide in 600 ml acetonitrile is heated at 65°C for 160 hours. The oil obtained is dissolved in methanol. The solution is cooled and crystalline scopolamine N-n-butylbromide is filtered. After recrystallization from methanol was obtained scopolamine N-n-butylbromide with melting point 142-144°C and [α]d 20 = -20.5° (3% solution in water); yield 65%.
Therapeutic Function
Anticholinergic, Spasmolytic, Antitussive
Biochem/physiol Actions
Competitive muscarinic acetylcholine receptor antagonist; antispasmodic.
Clinical Use
Symptomatic relief of gastrointestinal or genitourinary
disorders due to smooth muscle spasm
Bowel colic
Excessive respiratory secretions
target
AChR
Metabolism
The main metabolic pathway is the hydrolytic cleavage of the ester bond. Orally administered hyoscine butylbromide is excreted in the faeces and in the urine. Studies in man show that 2-5% of radioactive doses is eliminated renally after oral, and 0.7-1.6% after rectal administration. Approximately 90% of recovered radioactivity can be found in the faeces after oral administration. The urinary excretion of hyoscine butylbromide is less than 0.1% of the dose. The metabolites excreted via the renal route bind poorly to muscarinic receptors and are therefore not considered to contribute to the effect of the hyoscine butylbromide.
Scopolamine butylbromide Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12446 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615383190639 | admin@86-ss.com | China | 1000 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
View Lastest Price from Scopolamine butylbromide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-20 | Scopolamine butylbromide
149-64-4
|
US $999.00-800.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | ||
2024-09-20 | Scopolamine butylbromide; Flos?daturae extract
149-64-4
|
US $0.00 / G | 1G | ≥99% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | ||
2024-08-30 | Scopolamine butylbromide
149-64-4
|
US $13.00 / g | 10g | 99% | 100kg | Baoji Guokang Bio-Technology Co., Ltd. |
- Scopolamine butylbromide
149-64-4
- US $999.00-800.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
- Scopolamine butylbromide; Flos?daturae extract
149-64-4
- US $0.00 / G
- ≥99% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
- Scopolamine butylbromide
149-64-4
- US $13.00 / g
- 99%
- Baoji Guokang Bio-Technology Co., Ltd.
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