Isoliquiritigenin
- CAS No.
- 961-29-5
- Chemical Name:
- Isoliquiritigenin
- Synonyms
- ISL;ISOLIQUIRTIGENIN;(2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one;gu17;Isoliquiritigen;Isqliquiritigenin;ISOLIQUIRITIGENIN;ISOLIQUIRITIGENIN(P);Isoliquiritigenin>ISOLIQUIRITIGENIN(RG)
- CBNumber:
- CB9131280
- Molecular Formula:
- C15H12O4
- Molecular Weight:
- 256.25
- MDL Number:
- MFCD00075907
- MOL File:
- 961-29-5.mol
- MSDS File:
- SDS
| Melting point | 206-210°C |
|---|---|
| Boiling point | 504.0±42.0 °C(Predicted) |
| Density | 1.384±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | H2O: <0.1 mg/mL |
| pka | 7.50±0.35(Predicted) |
| form | powder |
| color | yellow to orange |
| Sensitive | Light Sensitive & Hygroscopic |
| BRN | 1914296 |
| InChIKey | DXDRHHKMWQZJHT-FPYGCLRLSA-N |
| LogP | 3.110 (est) |
| CAS DataBase Reference | 961-29-5(CAS DataBase Reference) |
| FDA UNII | B9CTI9GB8F |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | FL7080000 | |||||||||
| HS Code | 29145090 | |||||||||
| NFPA 704 |
|
Isoliquiritigenin price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I3766 | Isoliquiritigenin powder | 961-29-5 | 10mg | $461 | 2024-03-01 | Buy |
| Sigma-Aldrich | 38986 | Isoliquiritigenin analytical standard | 961-29-5 | 50mg | $195 | 2024-03-01 | Buy |
| TCI Chemical | I0822 | Isoliquiritigenin >97.0%(HPLC)(T) | 961-29-5 | 100mg | $23 | 2024-03-01 | Buy |
| TCI Chemical | I0822 | Isoliquiritigenin >97.0%(HPLC)(T) | 961-29-5 | 1g | $170 | 2024-03-01 | Buy |
| Alfa Aesar | H26920 | 2',4,4'-Trihydroxychalcone, 97% | 961-29-5 | 1g | $88.6 | 2021-12-16 | Buy |
Isoliquiritigenin Chemical Properties,Uses,Production
Chemical Properties
Yellow solid
Uses
aldose reductase inhibitor, antineoplastic, antiinflammatory
Uses
Isoliquiritigenin (ISL) is a flavonoid found in licorice root and several other plants that displays antioxidant, anti-inflammatory, and antitumor activities as well as hepatoprotection against steatosis-induced oxidative stress. ISL induces quinone reductase-1, a phase II enzyme that deactivates radicals and electrophiles, with a concentration required to double activity (CD) value of 1.8 μM in murine hepatoma cells.
Definition
ChEBI: Isoliquiritigenin is a member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'. It has a role as an EC 1.14.18.1 (tyrosinase) inhibitor, a biological pigment, a NMDA receptor antagonist, a GABA modulator, a metabolite, an antineoplastic agent and a geroprotector. It is functionally related to a trans-chalcone. It is a conjugate acid of an isoliquiritigenin(1-).
General Description
Isoliquiritigenin is an aromatic ketone and belongs to the chalcone group of compound. It is derived from licorice and is a component in medicine and food.
Biochem/physiol Actions
Isoliquiritigenin is a soluble guanylyl cyclase activator and possesses antitumor activity. It also possesses antioxidant, antiplatelet and estrogenic properties.
Anticancer Research
It is extracted from Dipteryx odorata seeds, found to be active in induction of quininereductase, and thus prevents chemical carcinogenesis. In a dose- and time-dependentmanner, it significantly inhibits the proliferation of prostate cancer cells,and this isoliquiritigenin-induced cell cycle arrest and antiproliferative effects maybe manifested by growth arrest- and DNA damage-inducible gene 153 (GADD153).It induces apoptosis in prostate cancer cells through mitochondrial apoptosispathway in which mitochondrial membrane potential is disrupted, cytochrome-cand Smac/Diablo are released, and caspase-9 is activated. It is reported to enhancethe expression of universal inhibitor of cyclin-dependent kinases, p21CIP1/WAF1, in adose- and time-dependent manner in A549 human lung cancer cells (Kanazawaet al. 2003; Ii et al. 2004; Balunas and Kinghorn 2005; Jung et al. 2006).
storage
+4°C
Isoliquiritigenin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | sales@zhswyy.com | China | 338 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
View Lastest Price from Isoliquiritigenin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-26 | Isoliquiritigenin
961-29-5
|
US $0.00-0.00 / kg | 0.10000000149011612kg | 20%-98%HPLC | 20tons | Chongqing Zhihe Biopharmaceutical Co., Ltd. | |
 |
2024-04-23 | Isoliquiritigenin Glycyrrhiza extract
961-29-5
|
US $0.00 / G | 1G | 98% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2023-08-29 | Isoliquiritigenin
961-29-5
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- Isoliquiritigenin
961-29-5
- US $0.00-0.00 / kg
- 20%-98%HPLC
- Chongqing Zhihe Biopharmaceutical Co., Ltd.
-
- Isoliquiritigenin Glycyrrhiza extract
961-29-5
- US $0.00 / G
- 98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Isoliquiritigenin
961-29-5
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd