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Cyclopentadecanolide

CAS No.
106-02-5
Chemical Name:
Cyclopentadecanolide
Synonyms
Exaltolide;PENTADECANOLIDE;OXACYCLOHEXADECAN-2-ONE;Exaltolide Total;ω-Pentadecalactone;PENTALIDE;Pentadecalactone;Pentadecan-15-olide;OMEGA-PENTADECALACTONE;Thibetolide
CBNumber:
CB9207055
Molecular Formula:
C15H28O2
Molecular Weight:
240.38
MDL Number:
MFCD00039667
MOL File:
106-02-5.mol
MSDS File:
SDS
Last updated:2024-04-26 17:21:34

Cyclopentadecanolide Properties

Melting point 34-38 °C(lit.)
Boiling point 137 °C2 mm Hg(lit.)
Density 0.918 g/mL at 25 °C(lit.)
vapor pressure 0.085Pa at 25℃
refractive index 1.4700
FEMA 2840 | OMEGA-PENTADECALACTONE
Flash point >230 °F
storage temp. Sealed in dry,Room Temperature
solubility Chloroform, Ethyl Acetate, Methanol (Slightly)
form Solid
color White to Off-White
Odor at 10.00 % in dipropylene glycol. musk animal powdery natural fruity
Odor Type musk
Water Solubility Soluble in alcohol, dipropylene glycol. Insoluble in water.
Merck 14,3910
JECFA Number 239
BRN 143710
LogP 5.79 at 25℃
Substances Added to Food (formerly EAFUS) OMEGA-PENTADECALACTONE
CAS DataBase Reference 106-02-5(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII OK17S3S98K
NIST Chemistry Reference Oxacyclohexadecan-2-one(106-02-5)
EPA Substance Registry System Oxacyclohexadecan-2-one (106-02-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS09
Signal word  Warning
Hazard statements  H410
Precautionary statements  P273-P391-P501
Safety Statements  24/25
WGK Germany  1
RTECS  RN9775000
TSCA  Yes
HS Code  29322090
Toxicity Both the acute oral LD50 value in rats and the acute dermal LD50 value in rabbits exceeded 5 g/kg (Levenstein, 1974).
NFPA 704
1
2 0

Cyclopentadecanolide price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W284009 ω-Pentadecalactone ≥98%,FG 106-02-5 1kg $322 2024-03-01 Buy
Sigma-Aldrich W284009 ω-Pentadecalactone ≥98%,FG 106-02-5 5kg $806 2024-03-01 Buy
Sigma-Aldrich 419133 Pentadecanolide 98% 106-02-5 25g $41.22 2024-03-01 Buy
Sigma-Aldrich 419133 Pentadecanolide 98% 106-02-5 100g $103.2 2024-03-01 Buy
Sigma-Aldrich W284009 ω-Pentadecalactone ≥98%,FG 106-02-5 100g $95.8 2023-01-07 Buy
Product number Packaging Price Buy
W284009 1kg $322 Buy
W284009 5kg $806 Buy
419133 25g $41.22 Buy
419133 100g $103.2 Buy
W284009 100g $95.8 Buy

Cyclopentadecanolide Chemical Properties,Uses,Production

Chemical Properties

ω-Pentadecalactone has an extraordinarily persistent, musk-like odor.

Chemical Properties

white crystalline low melting solid

Chemical Properties

Cyclopentadecanolide occurs in small quantities in, for example, angelica root oil. It forms colorless crystals (mp 37–38°C) with a delicate, musk-like odor.

Occurrence

Originally reported found in the essential oil from angelica roots.

Uses

Pentadecanolide is a monomer used to make PGA-co-pentadecalactone polymers to be used in the development of directly compressed prolonged release tablets of slightly soluble drugs such as ketoprofen.

Uses

Pentadecanolide may be used for the synthesis of poly(pentadecanolide) (PPDL) by Novozyme 435 catalyzed ring-opening polymerization. It may be employed as starting reagent for the synthesis of terminally-branched iso-fatty acids (iso-C15-C17).

Uses

As a fixative in perfumery.

Definition

ChEBI: Cyclopentadecanolide is a macrolide.

Preparation

The main industrial syntheses start from compounds produced from cyclododecatriene: either by ring expansion of cyclododecanone or by depolymerization of polyesters of 15-hydroxypentadecanoic acid (from 1,12-dodecanediol).

Aroma threshold values

Detection: 1 to 4 ppb

Taste threshold values

Taste characteristics at 75 ppm: vanilla bean, powdery helioropine, creamy and licorice.

Synthesis Reference(s)

Tetrahedron Letters, 34, p. 6107, 1993 DOI: 10.1016/S0040-4039(00)61741-0
The Journal of Organic Chemistry, 50, p. 2394, 1985 DOI: 10.1021/jo00213a044

General Description

Pentadecanolide is one of the major components, isolated from the root of Angelica archangelica L., species. It is a synthetic musk, which exists as a widespread contaminant in the environment.

Flammability and Explosibility

Non flammable

Trade name

Macrolide® (Symrise), Exaltolide®, Exaltolide®Total (Firmenich), Pentalide (Soda Aromatic).

Purification Methods

It has been recrystallised from MeOH (4 parts) at -15o. [Hundieck

76529-42-5
106-02-5
Synthesis of Cyclopentadecanolide from METHYL 15-HYDROXYPENTADECANOATE
Global( 260)Suppliers
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Hebei Mojin Biotechnology Co., Ltd
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View Lastest Price from Cyclopentadecanolide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cyclopentadecanolide pictures 2024-04-27 Cyclopentadecanolide
106-02-5
US $20.00 / kg 1kg 99.9% 200000kg Ouhuang Engineering Materials (Hubei) Co., Ltd
Cyclopentadecanolide pictures 2023-11-04 Cyclopentadecanolide
106-02-5
US $0.00-0.00 / kg 1kg 99% 50000kg Hebei Kingfiner Technology Development Co.Ltd
Cyclopentadecanolide pictures 2023-10-07 Cyclopentadecanolide
106-02-5
US $40.00-40.00 / kg 1kg 0.99 10 tons Hebei Yanxi Chemical Co., Ltd.
15-HYDROXYPENTADECANOIC ACID LACTONE Cyclopentadecanolide~15-Hydroxypentadecanoic acid lactone~omega-Pentadecalactone OMEGA-PENTADECALACTONE 98+% exaltolid CYCLOPENTADECENOLIDE Exaltolide, Oxacyclohexadecan-2-one CYCLOPENTADECANOLIDE (OXACYCLOHEXADECAN-2-ONE) 1-Oxa-2-cyclohexadecanone, 15-Hydroxypentadecanoic acid lactone, 15-Pentadecanolide, Pentadecanolide 1-Oxa-2-cyclohexadecanone, 15-Hydroxypentadecanoic acid lactone, 15-Pentadecanolide Pentadecanolide,1-Oxa-2-cyclohexadecanone, 15-Hydroxypentadecanoic acid lactone, 15-Pentadecanolide 1-hydroxycyclopentadecan-1-ide Cyclopentadecanolide, 98% 25GR CYCLOPENTADECANOLIDE OR OXACYCLOHEXADECAN-2-ONE exalltolide Pentalide(R) Exaltolide(R) Cyclopentadecanolide,98% O-PENTADECALACTONE FEMA 2840 CYCLOPENTADECANOLIDE 1-OXA-2-CYCLOHEXADECANONE 1,15-Pentadecanolide 15-hydroxy-pentadecanoicacixi-lactone 2-Pentadecalone Cyclopentadecanolactone Muskolactone pentadecan-15- Pentadecano-15-lactone Pentadecanoic acid, 15-hydroxy-, xi-lactone Pentadecanolactone 15-PENTADECANOLIDE W-PENTADECALACTONE Cyclopentadecanolide, FCC Pentadecanolide 98% Pentadecanolide puriss., >=99.0% (GC) Exaltolide (Firmenich) 16-oxabicyclo[13.2.0]heptadecan-17-one Pentadecan-15-olid PENTALIDE PENTADECANOLIDE OMEGA-PENTADECALACTONE OXACYCLOHEXADECAN-2-ONE Exaltolide Muskalactone Pentadecalactone Pentadecan-15-olide Thibetolide 15-PENTADECANOLACTONE Exaltolide Total Macrolide supra Cyclopentadecanolide USP/EP/BP 16-oxacyclohexadecan-1-one ω-Pentadecalactone Water-Soluble PENTADECALACTONE , Nano-Liposomal PENTADECALACTONE ater-Soluble PENTADECALACTONE , Nano-Liposomal PENTADECALACTONE 106-02-5 0106-02-05 C15H28O2