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n-Butyllithium

Chemical Properties Usage Identifying Procedures Warnings and precautions Category Explosivity characteristics Flammability characertistics Storage Extinguisher

CAS No. 109-72-8
Chemical Name: n-Butyllithium
Synonyms: N-BULI;正丁基锂1.6M;正丁基锂2.5M;BUTYLLITHIUM;LITHIUMBUTYL;butyl-lithiu;正丁基锂(1.6mol);正丁基锂(2.5mol);n-utyllithium;N-BUTYLLITHIUM
CBNumber: CB9702303
Molecular Formula: C4H9Li
Formula Weight: 64.06
MOL File: 109-72-8.mol
n-Butyllithium Property
Melting point : -95 °C
Boiling point : 80 °C
density : 0.68 g/mL at 20 °C
Fp : 10 °F
storage temp. : 2-8°C
solubility : Miscible with diethyl ether and cyclohexane.
form : liquid
color : yellow
Water Solubility : vigorous reaction
Sensitive : Air & Moisture Sensitive
BRN : 1209227
CAS DataBase Reference: 109-72-8(CAS DataBase Reference)
NIST Chemistry Reference: Butyl lithium(109-72-8)
EPA Substance Registry System: Lithium, butyl-(109-72-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : F,C,N
Risk Statements : 14/15-17-34-48/20-51/53-62-65-67-63-35-11-15-50/53-66
Safety Statements : 6-9-16-26-36/37/39-45-61-62-6A-46-43B-43-60-33-29-5
RIDADR : UN 3399 4.3/PG 1
WGK Germany : 3
F : 3-10
TSCA : Yes
HazardClass : 4.3
PackingGroup : I
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H250 Catches fire spontaneously if exposed to air Pyrophoric liquids; Pyrorophoric solids Category 1 Danger P210, P222, P280, P302+P334,P370+P378, P422
H252 Self-heating in large quantities; may catch fire Self-heating substances and mixtures Category 2 Warning P235+P410, P280, P407, P413, P420
H260 In contact with water releases flammable gases which may ignite spontaneously Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases Category 1 Danger P223, P231+P232, P280, P335+ P334,P370+P378, P402+P404, P501
H261 In contact with water releases flammable gas Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases Category 2
Category 3
Danger
Warning
P231+P232, P280, P370+P378,P402+P404, P501
H304 May be fatal if swallowed and enters airways Aspiration hazard Category 1 Danger
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H401 Toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 2 P273, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P201 Obtain special instructions before use.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P222 Do not allow contact with air.
P223 Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P262 Do not get in eyes, on skin, or on clothing.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P231+P232 Handle under inert gas. Protect from moisture.
P331 Do NOT induce vomiting.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P334 IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P422 Store contents under …

n-Butyllithium Chemical Properties,Usage,Production

Chemical Properties
Colorless or slightly yellow transparent liquid at room temperature, also comes in powder form. Boiling point is 80-90℃(0.013Pa), relative density is 0.68-0.70. Soluble in many organic solvents. Stable in room temperature, lithium hydride removable by heating. Disintegrates in water, soluble in hydrocarbons and ethers, forms complex compounds with ethers, amines, and sulfides, and uses N-hexane as a solvent.
Usage
N-Butyllithium solution is mostly used as a pharmaceutical intermediate to synthesize anionic polymerization initiator. It is also used to produce rubber (such as integral rubber SIBR, which is the most versatile diene rubber to date), fragrance, liquid crystal materials, and other industries. It is a chemical product intermediate, linking agent, alkylating agent, and polymerization catalyst. As a catalyst, N-Butyllithium is widely used as a pharmaceutical intermediate, liquid crystal monomer, and pesticide production catalyst. It is also widely used in organic syntheses, especially in growing carbon chains, and it is a staple laboratory product in reactions such as: 1) Metallization reaction: R-H + n-Butyl-Li → R-Li + Butane, in which the produced lithium alkyl can react with many substances. 2) Direct metallization: the aromatic compound that connects the substitute reacts with N-Butyllithium, and lithium metal can be attached to the aromatic compound. 3) Nucleophilic addition and substitution reaction. 4) Halogen-metal replacement.
Identifying Procedures
N-Butyllithium must be calibrated through single titration as follows:
1) Titration solution: 1mol/L SEC butanol/dimethylbenzene solution (butanol and dimethylbenzene must be dried with an activated 5A molecular sieve)
2) Indicator: 2,2’-dipyridine
3) Solvent: dimethylbenzene (must be dried with an activated 5A molecular sieve).
4) Operation method: Under the protection of argon, add magneton, 20ml dimethylbenzene and a small amount of indicator into a 100ml 3-lipped bottle with a tipping plug. Then use a precisely marked 2ml injector to swiftly transfer 2ml N-Butyllithium into the bottle (the air in the injector must be replaced with argon, which must then be expelled when collecting the N-Butyllithium; fill and drain the injector in the N-Butyllithium multiple times to prevent any water or air from remaining in the injector). The system should turn a purplish red. Then, wash, dry, and rinse the same injector with titration solution 2-3 times (to prevent any change in the amount added) and titrate the solution until the system turns yellow, and cease titration.
5) Repeat titration once; if the percent error between the two times is within 2%, the result can be regarded as correct.
6) Titration result: titration solution (ml)/2 to obtain N-Butyllithium concentration.
Warnings and precautions
1) N-Butyllithium is extremely combustible when in contact with air; when measuring, the needle of the injector will eject sparks.
2) The entire process must be protected by argon for safety precaution.
3) If N-Butyllithium catches fire, it must be extinguished with sand, which must be placed within arm’s reach at all times.
When preparing and using N-Butyllithium, do not operate alone in case of emergency
Category
Spontaneously combustible when in contact with water
Explosivity characteristics
May explode in combination with phenylethylene
Flammability characertistics
Combusts in air at a concentration abover 20%; combusts upon contact with water and carbon dioxide; flammable when in contact with heat and open flame.
Storage
Store in ventilated, cool and dry spaces; must be waterproof and carbon dioxide-proof.
Extinguisher
Dry powder
Chemical Properties
clear yellow solution
n-Butyllithium Preparation Products And Raw materials
Raw materials
Hexane 1-Bromobutane 1-Chlorobutane Litium
Preparation Products
4-CHLORO-2-METHYLPHENYLBORONIC ACID Benzofuran-2-boronic acid 2-Bromo-5-iodopyridine TRIS(PENTAFLUOROPHENYL)BORANE ETHYL 5-CHLOROTHIOPHENE-2-CARBOXYLATE 2-Chloropyridine-5-boronic acid 3-ISOPROPYLPHENYLBORONIC ACID 4-Carboxylphenylboronic acid pinacol ester 2,5-Dichlorophenylboronic acid 5-BROMOPYRIDINE-2-CARBONYL CHLORIDE 5-Chloropyridine-2-boronic acid Isoquinoline-4-carbaldehyde 3,4,5-TRICHLOROTHIOPHENE-2-CARBONYL CHLORIDE 2,3,6-TRIFLUOROBENZOIC ACID 2-Bromopyridine-5-boronic acid 2,4,6-Trifluorobenzoic acid 1,3-Thiazole-2-carbaldehyde 2-Cyanophenylboronic acid 4-METHYLDIBENZOTHIOPHENE DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE 4-Methoxyphenylboronic acid ,98% 4,5-DIBROMOTHIOPHENE-2-CARBOXALDEHYDE Ethyl 1-methyl-1H-pyrazole-5-carboxylate 1-BENZOTHIOPHENE-2-SULFONYL CHLORIDE 4-Hydroxyphenylboronic acid METHYL 3-BROMOTHIOPHENE-2-CARBOXYLATE 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID 2,4,6-Trichlorobenzoic acid 2-BROMOPYRIDIN-3-YLBORONIC ACID 5-Bromopyridine-3-boronic acid 3-BROMO-1-BENZOFURAN 2,4-Dibromothiophene 2,3,4-Tribromothiophene 5-Methoxypyridine-3-boronic acid 2,3-Difluorophenylboronic acid 1-Methyl-1H-pyrazole-5-carboxylic acid 1-Naphthylboronic acid Fenarimol 5-Methyl-2-pyridineboronic acid 4-N-BUTYLTOLUENE
n-Butyllithium Suppliers      Global( 215)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40403 62
Thermo Fisher Scientific 800-810-5118
+86-10-84193589 cnchemical@thermofisher.com China 17579 75
Xunteng International Trading Co.,Limited +00852-21527311 ; +86-07945259813; QQ:2332666069
+00852-30121311; +86-07945259813 xuntengchem@hotmail.com;sales@xuntengchem.com China Hong Kong 887 55
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd. 021-52696680
021-69106780 bangchem1@163.com China 8323 60
Adamas Reagent, Ltd. 400-600-9262
bxy@titansci.com China 14021 59
Lianyungang Yilong Chemical Co., Ltd. 18751413560、18360586801
0518-88109512 sales@yilong-chem.com China 22 60
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44197 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 sale@aladdin-e.com China 25125 65
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96831 76
JIANGXI AIFEIMU TECHNOLOGY CO.,LTD +86-570-6040288, 6040289
+86-570-6259526 sales@afmpharm.com China 96 61
 
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N-BUTYLLITHIUM, 10.5M IN HEXANE TERT-BUTYLLITHIUM,15%SOLUTIONINPENTANE N-BUTYLLITHIUM IN HEXANE SEC-BUTYLLITHIUM 1.3M IN CYCLOHEXANE Tri-n-butyllithium magnesate,TRI-N-BUTYLLITHIUM MAGNESATE, 0.7M IN & 15% N-BUTYLLITHIUM IN HEXANE 1-Bromobutane n-Butyllithium LITHIUM N-BUTYLCYCLOPENTADIENIDE N-OCTYLLITHIUM 2-ETHYLHEXYLLITHIUM LITHIUM N-PROPYLCYCLOPENTADIENIDE CYCLOPENTYLLITHIUM N-HEXYLLITHIUM tert-Butyl methyl ether Tetrabutylammonium bromide SEC-BUTYLLITHIUM: 12% (CA. 1.4M) SOL. IN CYCLOHEXANE,S-BUTYLLITHIUM: 11-12% IN CYCLOHEXANE (CA. 1M),SEC-BUTYLLITHIUM,1.3MSOLUTIONINCYCLOHEXANE,sec-Butyllithium, 1.3M in cyclohexane, packaged under Argon in resealable ChemSealTM bottles,sec-Butyllithium, 12% (ca 1.4M) soln. in cyclohexane,s-Butyllithium, 12% in cyclohexane (1.4M),sec-Butyllithium, 1.3M in cyclohexane, packaged under Argon in resealable ChemSeal^t bottles,S-BUTYLLITHIUM,SEC-BUTYLLITHIUM,sec-Butyllithium solution,SEC-BUTYLLITHIUM tert-Butyllithium, 1.6M solution in pentane,TERT-BUTYLLITHIUM, 1.9M SOLUTION IN PENTANE,tert-Butyllithium1.6M solution in pentaneAcroSeal§3,TERT-BUTYLLITHIUM 1.5M IN PENTANE,tert-Butyllithium, nominally 1.5M in n-pentane, packaged under Argon in resealable ChemSeal bottles,tert-Butyllithium, nominally 1.5M in n-pentane, packaged under Argon in resealable ChemSealTM bottles,tert-butyllithium, nominally 1.5m in n-pentane, packaged under argon in resealable chemseal,tert-Butyllithium, nominally 1
butyl-lithiu Lithiumn-butyl Classes of Metal Compounds Typical Metal Compounds Alkyl Metals Grignard Reagents & Alkyl Metals Li (Lithium) Compounds LITHIUM-1-BUTANIDE LITHIUMBUTYL BUTYLLITHIUM Alkyl 109-72-8 N-BULI N-BUTYLLITHIUM Organolithium Organometallic Reagents Butyllithium solution ButyllithiuminhexaneM BUTYLLITHIUM SOLUTION, ~2.7 M IN HEPTANE BUTYLLITHIUM SOLUTION, ~2.5 M IN TOLUENE BUTYLLITHIUM, 2.5M SOLUTION IN HEXANES BUTYLLITHIUM, 2.0M SOLUTION IN PENTANE BUTYLLITHIUM, 1.6M SOLUTION IN HEXANES BUTYLLITHIUM SOLUTION, ~1.6 M IN HEXANE BUTYLLITHIUM, 2.0M SOLUTION IN CYCLOHEXA NE BUTYLLITHIUM SOLUTION, ~10 M IN HEXANE BUTYLLITHIUM, 10.0M SOLUTION IN HEXANES N-butyl lithium Solution n-utyllithium n-Butyllithium, 1.6M solution in hexanes n-Butyllithium, 2.5M solution in hexanes n-Butyllithium, 2.6M solution in toluene n-Butyllithium,15%inhexane(1.6M) n-butyllithium, 1.6m in hexane n-butyllithium, 10.0m in hexanes n-butyllithium, 2.2m in hexane n-butyllithium, 2.2m in hexane, packaged under argon in resealable chemseal n-butyllithium, 2.5m in hexane Metal Compounds Organometallics N-BUTYLLITHIUM, 1.6M SOLUTION IN HEXANE n-Butyllithium, 2.2M in hexane, packaged under Argon in resealable ChemSealTM bottles n-Butyllithium, 2.5M in hexane (not in septum cap bottle) Butyllithium (ca. 15% in Hexane, ca. 1.6mol/L) Alkyl Metals Classes of Metal Compounds Grignard Reagents & Alkyl Metals Li (Lithium) Compounds Synthetic Organic Chemistry Typical Metal Compounds sec-Butyllithium, 1.3M in cyclohexane, packaged under Argon in resealable ChemSeal bottles n-Butyllithium, 2.2M in hexane, packaged under Argon in resealable ChemSeal bottles n-BuLi, Lithium-1-butanide CH3CH23Li Hexanes, Reagent N-BUTYLLITHIUM, 2.2M SOLUTION IN CYCLOHEXANE n-Butyllithium1.6M solution in hexanesAcroSeal§3 n-Butyllithium2.5M solution in hexanesAcroSeal§3
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