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n-Butyllithium

Chemical Properties Usage Identifying Procedures Warnings and precautions Category Explosivity characteristics Flammability characertistics Storage Extinguisher
n-Butyllithium
n-Butyllithium
CAS No.
109-72-8
Chemical Name:
n-Butyllithium
Synonyms
N-BULI;BUTYLLITHIUM;LITHIUMBUTYL;butyl-lithiu;n-utyllithium;N-BUTYLLITHIUM;Lithiumn-butyl;Hexanes, Reagent;LITHIUM-1-BUTANIDE;n-ButyllithiuM(BULI)
CBNumber:
CB9702303
Molecular Formula:
C4H9Li
Formula Weight:
64.06
MOL File:
109-72-8.mol
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n-Butyllithium Properties

Melting point:
-95 °C
Boiling point:
80 °C
Density 
0.68 g/mL at 20 °C
Flash point:
10 °F
storage temp. 
2-8°C
solubility 
Miscible with diethyl ether and cyclohexane.
form 
liquid
color 
yellow
Water Solubility 
vigorous reaction
Sensitive 
Air & Moisture Sensitive
BRN 
1209227
CAS DataBase Reference
109-72-8(CAS DataBase Reference)
NIST Chemistry Reference
Butyl lithium(109-72-8)
EPA Substance Registry System
Lithium, butyl-(109-72-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  F,C,N
Risk Statements  14/15-17-34-48/20-51/53-62-65-67-63-35-11-15-50/53-66
Safety Statements  6-9-16-26-36/37/39-45-61-62-6A-46-43B-43-60-33-29-5
RIDADR  UN 3399 4.3/PG 1
WGK Germany  3
F  3-10
TSCA  Yes
HazardClass  4.3
PackingGroup  I
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H250 Catches fire spontaneously if exposed to air Pyrophoric liquids; Pyrorophoric solids Category 1 Danger P210, P222, P280, P302+P334,P370+P378, P422
H252 Self-heating in large quantities; may catch fire Self-heating substances and mixtures Category 2 Warning P235+P410, P280, P407, P413, P420
H260 In contact with water releases flammable gases which may ignite spontaneously Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases Category 1 Danger P223, P231+P232, P280, P335+ P334,P370+P378, P402+P404, P501
H261 In contact with water releases flammable gas Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases Category 2
Category 3		 Danger
Warning		 P231+P232, P280, P370+P378,P402+P404, P501
H304 May be fatal if swallowed and enters airways Aspiration hazard Category 1 Danger
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H401 Toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 2 P273, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P201 Obtain special instructions before use.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P222 Do not allow contact with air.
P223 Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P262 Do not get in eyes, on skin, or on clothing.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P231+P232 Handle under inert gas. Protect from moisture.
P331 Do NOT induce vomiting.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P334 IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P422 Store contents under …

n-Butyllithium price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 186171 n-Butyllithium solution 1.6M in hexanes 109-72-8 8l $702 2017-11-08 Buy
Sigma-Aldrich 186171 n-Butyllithium solution 1.6M in hexanes 109-72-8 8l-kl $723 2017-11-08 Buy
Alfa Aesar L13559 n-Butyllithium, 1.6M in hexane, packaged in resealable septum cap bottle 109-72-8 100ml $72 2017-11-08 Buy
Alfa Aesar L13559 n-Butyllithium, 1.6M in hexane, packaged in resealable septum cap bottle 109-72-8 500ml $136 2017-11-08 Buy
Strem Chemicals 93-0301 n-Butyllithium, 15% in hexanes (1.6M) 109-72-8 0.25mole $98 2017-11-27 Buy

n-Butyllithium Chemical Properties,Uses,Production

Chemical Properties

Colorless or slightly yellow transparent liquid at room temperature, also comes in powder form. Boiling point is 80-90℃（0.013Pa）, relative density is 0.68-0.70. Soluble in many organic solvents. Stable in room temperature, lithium hydride removable by heating. Disintegrates in water, soluble in hydrocarbons and ethers, forms complex compounds with ethers, amines, and sulfides, and uses N-hexane as a solvent.

Usage

N-Butyllithium solution is mostly used as a pharmaceutical intermediate to synthesize anionic polymerization initiator. It is also used to produce rubber (such as integral rubber SIBR, which is the most versatile diene rubber to date), fragrance, liquid crystal materials, and other industries. It is a chemical product intermediate, linking agent, alkylating agent, and polymerization catalyst. As a catalyst, N-Butyllithium is widely used as a pharmaceutical intermediate, liquid crystal monomer, and pesticide production catalyst. It is also widely used in organic syntheses, especially in growing carbon chains, and it is a staple laboratory product in reactions such as: 1) Metallization reaction: R-H + n-Butyl-Li → R-Li + Butane, in which the produced lithium alkyl can react with many substances. 2) Direct metallization: the aromatic compound that connects the substitute reacts with N-Butyllithium, and lithium metal can be attached to the aromatic compound. 3) Nucleophilic addition and substitution reaction. 4) Halogen-metal replacement.

Identifying Procedures

N-Butyllithium must be calibrated through single titration as follows:
1) Titration solution: 1mol/L SEC butanol/dimethylbenzene solution (butanol and dimethylbenzene must be dried with an activated 5A molecular sieve)
2) Indicator: 2,2’-dipyridine
3) Solvent: dimethylbenzene (must be dried with an activated 5A molecular sieve).
4) Operation method: Under the protection of argon, add magneton, 20ml dimethylbenzene and a small amount of indicator into a 100ml 3-lipped bottle with a tipping plug. Then use a precisely marked 2ml injector to swiftly transfer 2ml N-Butyllithium into the bottle (the air in the injector must be replaced with argon, which must then be expelled when collecting the N-Butyllithium; fill and drain the injector in the N-Butyllithium multiple times to prevent any water or air from remaining in the injector). The system should turn a purplish red. Then, wash, dry, and rinse the same injector with titration solution 2-3 times (to prevent any change in the amount added) and titrate the solution until the system turns yellow, and cease titration.
5) Repeat titration once; if the percent error between the two times is within 2%, the result can be regarded as correct.
6) Titration result: titration solution (ml)/2 to obtain N-Butyllithium concentration.

Warnings and precautions

1) N-Butyllithium is extremely combustible when in contact with air; when measuring, the needle of the injector will eject sparks.
2) The entire process must be protected by argon for safety precaution.
3) If N-Butyllithium catches fire, it must be extinguished with sand, which must be placed within arm’s reach at all times.
When preparing and using N-Butyllithium, do not operate alone in case of emergency

Category

Spontaneously combustible when in contact with water

Explosivity characteristics

May explode in combination with phenylethylene

Flammability characertistics

Combusts in air at a concentration abover 20%; combusts upon contact with water and carbon dioxide; flammable when in contact with heat and open flame.

Storage

Store in ventilated, cool and dry spaces; must be waterproof and carbon dioxide-proof.

Extinguisher

Dry powder

Chemical Properties

clear yellow solution

n-Butyllithium Preparation Products And Raw materials

Raw materials

Hexane 1-Bromobutane 1-Chlorobutane Litium

Preparation Products

4-CHLORO-2-METHYLPHENYLBORONIC ACID Benzofuran-2-boronic acid 2-Bromo-5-iodopyridine TRIS(PENTAFLUOROPHENYL)BORANE ETHYL 5-CHLOROTHIOPHENE-2-CARBOXYLATE 2-Chloropyridine-5-boronic acid 3-ISOPROPYLPHENYLBORONIC ACID 4-Carboxylphenylboronic acid pinacol ester 2,5-Dichlorophenylboronic acid 5-BROMOPYRIDINE-2-CARBONYL CHLORIDE 5-Chloropyridine-2-boronic acid Isoquinoline-4-carbaldehyde 3,4,5-TRICHLOROTHIOPHENE-2-CARBONYL CHLORIDE 2,3,6-TRIFLUOROBENZOIC ACID 2-Bromopyridine-5-boronic acid 2,4,6-Trifluorobenzoic acid 1,3-Thiazole-2-carbaldehyde 2-Cyanophenylboronic acid 4-METHYLDIBENZOTHIOPHENE DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE 4-Methoxyphenylboronic acid ,98% 4,5-DIBROMOTHIOPHENE-2-CARBOXALDEHYDE Ethyl 1-methyl-1H-pyrazole-5-carboxylate 1-BENZOTHIOPHENE-2-SULFONYL CHLORIDE 4-Hydroxyphenylboronic acid METHYL 3-BROMOTHIOPHENE-2-CARBOXYLATE 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID 2,4,6-Trichlorobenzoic acid 2-BROMOPYRIDIN-3-YLBORONIC ACID 5-Bromopyridine-3-boronic acid 3-BROMO-1-BENZOFURAN 2,4-Dibromothiophene 2,3,4-Tribromothiophene 5-Methoxypyridine-3-boronic acid 2,3-Difluorophenylboronic acid 1-Methyl-1H-pyrazole-5-carboxylic acid 1-Naphthylboronic acid Fenarimol 5-Methyl-2-pyridineboronic acid 4-N-BUTYLTOLUENE

n-Butyllithium Suppliers

Global( 224)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd. 		+86-10-60279497 +86(0)15646567669
 +86-10-60279497 sales01@cooperate-pharm.com CHINA 1214 55
Henan Tianfu Chemical Co.,Ltd. 		0371-55170693
 0371-55170693 info@tianfuchem.com CHINA 20810 55
Mainchem Co., Ltd. 		+86-0592-6210733
 +86-0592-6210733 sales@mainchem.com CHINA 32767 55
Hangzhou FandaChem Co.,Ltd. 		0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
 +86-571-56059825 fandachem@gmail.com CHINA 749 55
Hefei TNJ Chemical Industry Co.,Ltd. 		86-0551-65418684 18949823763
 86-0551-65418684 info@tnjchem.com China 1410 55
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
 +86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40398 62
Xunteng International Trading Co.,Limited +00852-21527311 ; +86-07945259813; QQ:2332666069
 +00852-30121311; +86-07945259813 xuntengchem@hotmail.com;sales@xuntengchem.com China Hong Kong 888 55
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd. 021-52696680
 021-69106780 bangchem1@163.com China 8323 60
Adamas Reagent, Ltd. 400-600-9262
 bxy@titansci.com China 14018 59
Lianyungang Yilong Chemical Co., Ltd. 18751413560、18360586801
 0518-88109512 sales@yilong-chem.com China 22 60

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