n-Butyllithium
Chemical Properties
Usage
Identifying Procedures
Warnings and precautions
Category
Explosivity characteristics
Flammability characertistics
Storage
Extinguisher
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n-Butyllithium Properties
- Melting point:
- -95 °C
- Boiling point:
- 80 °C
- Density
- 0.68 g/mL at 20 °C
- Flash point:
- 10 °F
- storage temp.
- 2-8°C
- solubility
- Miscible with diethyl ether and cyclohexane.
- form
- liquid
- color
- yellow
- Water Solubility
- vigorous reaction
- Sensitive
- Air & Moisture Sensitive
- BRN
- 1209227
- CAS DataBase Reference
- 109-72-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Butyl lithium(109-72-8)
- EPA Substance Registry System
- Lithium, butyl-(109-72-8)
SAFETY
- Risk and Safety Statements
- Hazard and Precautionary Statements (GHS)
Hazard Codes | F,C,N | ||
---|---|---|---|
Risk Statements | 14/15-17-34-48/20-51/53-62-65-67-63-35-11-15-50/53-66 | ||
Safety Statements | 6-9-16-26-36/37/39-45-61-62-6A-46-43B-43-60-33-29-5 | ||
RIDADR | UN 3399 4.3/PG 1 |
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WGK Germany | 3 |
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F | 3-10 | ||
TSCA | Yes | ||
HazardClass | 4.3 | ||
PackingGroup | I |
Symbol(GHS): |
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Signal word: | Danger | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Hazard statements: |
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Precautionary statements: |
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n-Butyllithium price More Price(31)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 186171 | n-Butyllithium solution 1.6M in hexanes | 109-72-8 | 8l | $702 | 2017-11-08 | Buy |
Sigma-Aldrich | 186171 | n-Butyllithium solution 1.6M in hexanes | 109-72-8 | 8l-kl | $723 | 2017-11-08 | Buy |
Alfa Aesar | L13559 | n-Butyllithium, 1.6M in hexane, packaged in resealable septum cap bottle | 109-72-8 | 100ml | $72 | 2017-11-08 | Buy |
Alfa Aesar | L13559 | n-Butyllithium, 1.6M in hexane, packaged in resealable septum cap bottle | 109-72-8 | 500ml | $136 | 2017-11-08 | Buy |
Strem Chemicals | 93-0301 | n-Butyllithium, 15% in hexanes (1.6M) | 109-72-8 | 0.25mole | $98 | 2017-11-27 | Buy |
n-Butyllithium Chemical Properties,Uses,Production
Chemical Properties
Colorless or slightly yellow transparent liquid at room temperature, also comes in powder form. Boiling point is 80-90℃(0.013Pa), relative density is 0.68-0.70. Soluble in many organic solvents. Stable in room temperature, lithium hydride removable by heating. Disintegrates in water, soluble in hydrocarbons and ethers, forms complex compounds with ethers, amines, and sulfides, and uses N-hexane as a solvent.Usage
N-Butyllithium solution is mostly used as a pharmaceutical intermediate to synthesize anionic polymerization initiator. It is also used to produce rubber (such as integral rubber SIBR, which is the most versatile diene rubber to date), fragrance, liquid crystal materials, and other industries. It is a chemical product intermediate, linking agent, alkylating agent, and polymerization catalyst. As a catalyst, N-Butyllithium is widely used as a pharmaceutical intermediate, liquid crystal monomer, and pesticide production catalyst. It is also widely used in organic syntheses, especially in growing carbon chains, and it is a staple laboratory product in reactions such as: 1) Metallization reaction: R-H + n-Butyl-Li → R-Li + Butane, in which the produced lithium alkyl can react with many substances. 2) Direct metallization: the aromatic compound that connects the substitute reacts with N-Butyllithium, and lithium metal can be attached to the aromatic compound. 3) Nucleophilic addition and substitution reaction. 4) Halogen-metal replacement.Identifying Procedures
N-Butyllithium must be calibrated through single titration as follows:1) Titration solution: 1mol/L SEC butanol/dimethylbenzene solution (butanol and dimethylbenzene must be dried with an activated 5A molecular sieve)
2) Indicator: 2,2’-dipyridine
3) Solvent: dimethylbenzene (must be dried with an activated 5A molecular sieve).
4) Operation method: Under the protection of argon, add magneton, 20ml dimethylbenzene and a small amount of indicator into a 100ml 3-lipped bottle with a tipping plug. Then use a precisely marked 2ml injector to swiftly transfer 2ml N-Butyllithium into the bottle (the air in the injector must be replaced with argon, which must then be expelled when collecting the N-Butyllithium; fill and drain the injector in the N-Butyllithium multiple times to prevent any water or air from remaining in the injector). The system should turn a purplish red. Then, wash, dry, and rinse the same injector with titration solution 2-3 times (to prevent any change in the amount added) and titrate the solution until the system turns yellow, and cease titration.
5) Repeat titration once; if the percent error between the two times is within 2%, the result can be regarded as correct.
6) Titration result: titration solution (ml)/2 to obtain N-Butyllithium concentration.
Warnings and precautions
1) N-Butyllithium is extremely combustible when in contact with air; when measuring, the needle of the injector will eject sparks.2) The entire process must be protected by argon for safety precaution.
3) If N-Butyllithium catches fire, it must be extinguished with sand, which must be placed within arm’s reach at all times.
When preparing and using N-Butyllithium, do not operate alone in case of emergency
Category
Spontaneously combustible when in contact with waterExplosivity characteristics
May explode in combination with phenylethyleneFlammability characertistics
Combusts in air at a concentration abover 20%; combusts upon contact with water and carbon dioxide; flammable when in contact with heat and open flame.Storage
Store in ventilated, cool and dry spaces; must be waterproof and carbon dioxide-proof.Extinguisher
Dry powderChemical Properties
clear yellow solutionn-Butyllithium Preparation Products And Raw materials
Raw materials
Preparation Products
4-CHLORO-2-METHYLPHENYLBORONIC ACID
Benzofuran-2-boronic acid
2-Bromo-5-iodopyridine
TRIS(PENTAFLUOROPHENYL)BORANE
ETHYL 5-CHLOROTHIOPHENE-2-CARBOXYLATE
2-Chloropyridine-5-boronic acid
3-ISOPROPYLPHENYLBORONIC ACID
4-Carboxylphenylboronic acid pinacol ester
2,5-Dichlorophenylboronic acid
5-BROMOPYRIDINE-2-CARBONYL CHLORIDE
5-Chloropyridine-2-boronic acid
Isoquinoline-4-carbaldehyde
3,4,5-TRICHLOROTHIOPHENE-2-CARBONYL CHLORIDE
2,3,6-TRIFLUOROBENZOIC ACID
2-Bromopyridine-5-boronic acid
2,4,6-Trifluorobenzoic acid
1,3-Thiazole-2-carbaldehyde
2-Cyanophenylboronic acid
4-METHYLDIBENZOTHIOPHENE
DIMETHYL(3-PHENOXY-2-OXOPROPYL)PHOSPHONATE
4-Methoxyphenylboronic acid ,98%
4,5-DIBROMOTHIOPHENE-2-CARBOXALDEHYDE
Ethyl 1-methyl-1H-pyrazole-5-carboxylate
1-BENZOTHIOPHENE-2-SULFONYL CHLORIDE
4-Hydroxyphenylboronic acid
METHYL 3-BROMOTHIOPHENE-2-CARBOXYLATE
2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID
2,4,6-Trichlorobenzoic acid
2-BROMOPYRIDIN-3-YLBORONIC ACID
5-Bromopyridine-3-boronic acid
3-BROMO-1-BENZOFURAN
2,4-Dibromothiophene
2,3,4-Tribromothiophene
5-Methoxypyridine-3-boronic acid
2,3-Difluorophenylboronic acid
1-Methyl-1H-pyrazole-5-carboxylic acid
1-Naphthylboronic acid
Fenarimol
5-Methyl-2-pyridineboronic acid
4-N-BUTYLTOLUENE
n-Butyllithium Suppliers
Global( 223)Suppliers
Supplier | Tel | Fax | Country | ProdList | Advantage | |
---|---|---|---|---|---|---|
Beijing Cooperate Pharmaceutical Co.,Ltd. | +86-10-60279497 +86(0)15646567669 |
+86-10-60279497 | sales01@cooperate-pharm.com | CHINA | 1112 | 55 |
Henan Tianfu Chemical Co.,Ltd. | 0371-55170693 |
0371-55170693 | info@tianfuchem.com | CHINA | 20810 | 55 |
Mainchem Co., Ltd. | 0592-6210733 |
0592-6210733 | sales@mainchem.com | CHINA | 3270 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | 86-0551-65418684 18949823763 |
86-0551-65418684 | info@tnjchem.com | China | 1410 | 55 |
Meryer (Shanghai) Chemical Technology Co., Ltd. | +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing) |
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) | sh@meryer.com | China | 40398 | 62 |
Thermo Fisher Scientific | 800-810-5118 |
+86-10-84193589 | cnchemical@thermofisher.com | China | 17574 | 75 |
Xunteng International Trading Co.,Limited | +00852-21527311 ; +86-07945259813; QQ:2332666069 |
+00852-30121311; +86-07945259813 | xuntengchem@hotmail.com;sales@xuntengchem.com | China Hong Kong | 888 | 55 |
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd. | 021-52696680 |
021-69106780 | bangchem1@163.com | China | 8323 | 60 |
Adamas Reagent, Ltd. | 400-600-9262 |
bxy@titansci.com | China | 14018 | 59 | |
Lianyungang Yilong Chemical Co., Ltd. | 18751413560、18360586801 |
0518-88109512 | sales@yilong-chem.com | China | 22 | 60 |
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- butyl-lithiu
- Lithiumn-butyl
- Classes of Metal Compounds
- Typical Metal Compounds
- Alkyl Metals
- Grignard Reagents & Alkyl Metals
- Li (Lithium) Compounds
- LITHIUM-1-BUTANIDE
- LITHIUMBUTYL
- BUTYLLITHIUM
- Alkyl
- 109-72-8
- N-BULI
- N-BUTYLLITHIUM
- Organolithium
- Organometallic Reagents
- Butyllithium solution
- ButyllithiuminhexaneM
- BUTYLLITHIUM SOLUTION, ~2.7 M IN HEPTANE
- BUTYLLITHIUM SOLUTION, ~2.5 M IN TOLUENE
- BUTYLLITHIUM, 2.5M SOLUTION IN HEXANES
- BUTYLLITHIUM, 2.0M SOLUTION IN PENTANE
- BUTYLLITHIUM, 1.6M SOLUTION IN HEXANES
- BUTYLLITHIUM SOLUTION, ~1.6 M IN HEXANE
- BUTYLLITHIUM, 2.0M SOLUTION IN CYCLOHEXA NE
- BUTYLLITHIUM SOLUTION, ~10 M IN HEXANE
- BUTYLLITHIUM, 10.0M SOLUTION IN HEXANES
- N-butyl lithium Solution
- n-utyllithium
- n-Butyllithium, 1.6M solution in hexanes
- n-Butyllithium, 2.5M solution in hexanes
- n-Butyllithium, 2.6M solution in toluene
- n-Butyllithium,15%inhexane(1.6M)
- n-butyllithium, 1.6m in hexane
- n-butyllithium, 10.0m in hexanes
- n-butyllithium, 2.2m in hexane
- n-butyllithium, 2.2m in hexane, packaged under argon in resealable chemseal
- n-butyllithium, 2.5m in hexane
- Metal Compounds
- Organometallics
- N-BUTYLLITHIUM, 1.6M SOLUTION IN HEXANE
- n-Butyllithium, 2.2M in hexane, packaged under Argon in resealable ChemSealTM bottles
- n-Butyllithium, 2.5M in hexane (not in septum cap bottle)
- Butyllithium (ca. 15% in Hexane, ca. 1.6mol/L)
- Alkyl Metals
- Classes of Metal Compounds
- Grignard Reagents & Alkyl Metals
- Li (Lithium) Compounds
- Synthetic Organic Chemistry
- Typical Metal Compounds
- sec-Butyllithium, 1.3M in cyclohexane, packaged under Argon in resealable ChemSeal bottles
- n-Butyllithium, 2.2M in hexane, packaged under Argon in resealable ChemSeal bottles
- n-BuLi, Lithium-1-butanide
- CH3CH23Li
- Hexanes, Reagent
- N-BUTYLLITHIUM, 2.2M SOLUTION IN CYCLOHEXANE
- n-Butyllithium1.6M solution in hexanesAcroSeal§3
- n-Butyllithium2.5M solution in hexanesAcroSeal§3