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ChemicalBook >> CAS DataBase List >>9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE

9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE

9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Structure
9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE structure
CAS No.
3519-82-2
Chemical Name:
9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE
Synonyms
INCA-6;Nsc25996;NFAT Activation Inhibitor III;INCA-6 NFAT Activation Inhibitor III;9,10-[1,2]benzenoanthracene-13,16(9H,10H)-dione;9,10-[1,2]Benzeno-9,10-dihydro-1,4-anthraquinone;9,10-Dihydro-9,10-[1,2]benzeno-1,4-anthraquinone;9,10-[1,2]Benzeno-9,10-dihydroanthracene-1,4-dione;9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE;9,10[1',2']-Benzenoanthracene-1,4-dione, 9,10-dihydro-
CBNumber:
CB9839254
Molecular Formula:
C20H12O2
Molecular Weight:
284.31
MDL Number:
MFCD00226933
MOL File:
3519-82-2.mol
Last updated:2023-09-04 15:51:00
Request For Quotation

9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Properties

storage temp. Store at RT
solubility Soluble in DMSO
form Yellow solid

9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 480403 NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem 3519-82-2 5mg $187 2024-03-01 Buy
Cayman Chemical 21812 NFAT Activation Inhibitor III ≥98% 3519-82-2 5mg $62 2024-03-01 Buy
Cayman Chemical 21812 NFAT Activation Inhibitor III ≥98% 3519-82-2 10mg $115 2024-03-01 Buy
Cayman Chemical 21812 NFAT Activation Inhibitor III ≥98% 3519-82-2 25mg $270 2024-03-01 Buy
Cayman Chemical 21812 NFAT Activation Inhibitor III ≥98% 3519-82-2 50mg $477 2024-03-01 Buy
Product number Packaging Price Buy
480403 5mg $187 Buy
21812 5mg $62 Buy
21812 10mg $115 Buy
21812 25mg $270 Buy
21812 50mg $477 Buy

9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Chemical Properties,Uses,Production

Description

NFAT activation inhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT). It binds the substrate recognition site of the phosphatase calcineurin (Kd = 0.8 μM), preventing it from binding and dephosphorylating NFAT. NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin . It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin.

Uses

INCA 6 inhibits nuclear factor of activated T cells (NFAT) dephosphorylation and nuclear import, which in turn, interferes with downstream targets of NFAT including induction of cytokine mRNAs.

Definition

ChEBI: LSM-2729 is an anthraquinone.

General Description

A cell-permeable, potent, and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT, and completely blocks calcineurin-dependent NFAT dephosphorylation, nuclear import (~40 μM in C1.7W2 T cells), and induction of NFAT-targeted cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling.

Biological Activity

Inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (K d = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.

Biochem/physiol Actions

Cell permeable: yes

storage

Store at -20°C

9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Preparation Products And Raw materials

Raw materials

Preparation Products

9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Suppliers

Global( 37)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
Spectrum Chemical Manufacturing Corp. 021-021-021-67601398-809-809-809 15221380277 marketing_china@spectrumchemical.com China 9664 60
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2784 58
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088 3193328036@qq.com China 29797 68
Shanghai TenSus Biotechnology Co., Ltd. 021-50895067 18616507272 tensus@163.com China 4207 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 4030 58
Supplier Advantage
Aladdin Scientific 		58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Spectrum Chemical Manufacturing Corp. 60
AdooQ BioScience, LLC 58
EMMX Biotechnology LLC 60
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Shanghai TenSus Biotechnology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
MedBioPharmaceutical Technology Inc 58
Nantong QuanYi Biotechnology Co., Ltd 58

9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Spectrum

9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE(3519-82-2)1HNMR

3519-82-2(9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE)Related Search:

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1,4,9,10-Tetrahydro-9,10-[1,2]benzenoanthracene-1,4-dione 9,10-[1,2]Benzeno-1,4,9,10-tetrahydroanthracene-1,4-dione 9,10-[1,2]Benzeno-9,10-dihydro-1,4-anthraquinone 9,10-[1,2]Benzeno-9,10-dihydroanthracene-1,4-dione 9,10-Dihydro-9,10-[1,2]benzeno-1,4-anthraquinone Nsc25996 NFAT Activation Inhibitor III INCA-6 9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE INCA-6 NFAT Activation Inhibitor III 9,10-[1,2]benzenoanthracene-13,16(9H,10H)-dione 9,10[1',2']-Benzenoanthracene-1,4-dione, 9,10-dihydro- factors,inhibit,INCA-6,NFAT,microvascular,INCA 6,transcription,endothelial,Inhibitor,retinopathy,oxygen-induced,INCA6,retinal,neovascularization 3519-82-2 C20H12O2 Protein Phosphatase