ロスコビチン

ロスコビチン 価格 もっと(5)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01W0118-0159	ロスコビチン 98.0+% (HPLC) Roscovitine 98.0+% (HPLC)	186692-46-6	1mg	￥7700	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TRCR684000	ロスコビチン Roscovitine	186692-46-6	25mg	￥67200	2024-03-01	購入
Sigma-Aldrich Japan	R7772	ロスコビチン ≥98% (TLC) Roscovitine ≥98% (TLC)	186692-46-6	1mg	￥22800	2024-03-01	購入
Sigma-Aldrich Japan	R7772	ロスコビチン ≥98% (TLC) Roscovitine ≥98% (TLC)	186692-46-6	5mg	￥91700	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01W0118-0159	ロスコビチン 98.0+% (HPLC) Roscovitine 98.0+% (HPLC)	186692-46-6	10mg	￥38500	2024-03-01	購入

ロスコビチン 化学特性,用途語,生産方法

外観

白色～ほとんど白色, 結晶性粉末～粉末

溶解性

メタノール……1mg/mlDMSOに可溶エタノール及びアセトンに溶け、水に溶けない。

用途

アルツハイマー病研究用。

定義

ChEBI: 2,6-Diaminopurine carrying benzylamino, (2R)-1-hydroxybutan-2-yl and isopropyl substituents at C-6, C-2-N and N-9 respectively. It is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors.

一般的な説明

A potent, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks) that exhibits about ten-fold greater efficacy towards p34^cdk1 and p33^cdk2 and twenty-fold greater efficacy towards p33^cdk5 relative to Olomoucine (Cat. No. 495620). Inhibits p34^cdk1/cyclin B (IC₅₀ = 650 nM), p33^cdk2/cyclin A (IC₅₀ = 700 nM), p33^cdk2/cyclin E (IC₅₀ = 700 nM), and p33^cdk5/p35 (IC₅₀ = 200 nM) by competing for the ATP binding domain of the kinases. Exhibits reduced sensitivity towards related kinases including ERK1 and ERK2 (IC₅₀ = 34 μM and 14 μM, respectively). Roscovitine does not significantly affect the activity of other protein kinases even at 100 μM, including p34^cdk4/cyclin D1 and p40^cdk6/cyclin D2. Compared to olomoucine, roscovitine displays increased anti-mitotic activity at the G₁/S and G₂/M phases of the cell cycle. A 50 mM (5 mg/282 μl) solution of Roscovitine (Cat. No. 557364) in DMSO is also available.

抗がん研究

Roscovitine a derivative of olomoucine which is isolated from Raphanus sativus isunder clinical trials (Shoeb 2006).

ロスコビチン 上流と下流の製品情報

原材料

準備製品

ロスコビチン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shanghai Gubang New Materail Technology Co. LTD	21-51317962 +8618721305404	16728589@qq.com	CHINA	272	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58

186692-46-6(ロスコビチン)キーワード:

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• 186692-46-6
• 2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
• (2R)-2-[[6-(benzylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol
• 2-(R)-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE
• 2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE
• 6-BENZYLAMINO-2-(R)-[(1-ETHYL)-2-HYDROXYETHYLAMINO]-9-ISOPROPYLPURINE
• ROSCOVITINE
• (R)-ROSCOVITINE
• (R)-2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE
• P34 CDC2
• R-ROSCOVITINE 98% (HPLC)
• ROSCOVITINE 95+%
• 1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-
• 2-(r)-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9h-purin-2-yl]amino]-1-butanol
• 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
• Roscovitine (CYC202,Seliciclib)
• 6-Benzylamino-2[(R)-(1'-ethyl-2'-hydroxyethylamino)]-9-isopropylpurine Roscovitine
• Roscovitine,2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
• Roscovitine(CYC202)
• 2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]-
• (R)-2-(1-ETHY
• Roscovitine (Seliciclib)
• (2R)-2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]-1-butanol
• (R)-2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]-1-butanol
• CYC 202
• Roscoviline
• Posiphe
• CYC-202(ROSCOVITINE)
• 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine
• 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine (Seliciclib,CYC202)
• Roscovitine (R)-Roscovitine
• ロスコビチン
• (2S)-2-[6-(ベンジルアミノ)-9-(プロパン-2-イル)-9H-プリン-2-イル]ブタン-1-オール
• セリシクリブ
• (R)-2-[[6-(ベンジルアミノ)-9-イソプロピル-9H-プリン-2-イル]アミノ]-1-ブタノール
• 6-(ベンジルアミノ)-9-イソプロピル-N-[(R)-1-(ヒドロキシメチル)プロピル]-9H-プリン-2-アミン
• (R)-ロスコビチン
• (2R)-2-{[6-(ベンジルアミノ)-9-(プロパン-2-イル)-9H-プリン-2-イル]アミノ}ブタン-1-オール
• 2-[[(R)-1-(ヒドロキシメチル)プロピル]アミノ]-6-(ベンジルアミノ)-9-イソプロピル-9H-プリン
• 2-[(S)-1-エチル-2-ヒドロキシエチル]-9-イソプロピル-6-(ベンジルアミノ)-9H-プリン