ノルエルゲストロミン
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- CAS番号.
- 53016-31-2
- 化学名:
- ノルエルゲストロミン
- 别名:
- [17R,(+)]-17-ヒドロキシ-13-エチル-18,19-ジノルプレグナ-4-エン-20-イン-3-オンオキシム;ノルエルゲストロミン;17-デアセチルノルゲスチマート;(17R)-13-エチル-17-ヒドロキシ-18,19-ジノル-プレグナ-4-エン-20-イン-3-オンオキシム;デアセチルノルゲスチメート ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE);(1R,3aS,3bR,9aR,9bS,11aS)-11a-エチル-1-エチニル-7-(ヒドロキシイミノ)-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-シクロペンタ[a]フェナントレン-1-オール
- 英語名:
- DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)
- 英語别名:
- RWJ 10553;BRN 4202099;levonorgestreloxime;D-Norgestrel 3-oxime;(-)-NorelgestroMin-d6;Desacetylnorgestimate;17-Deacylnorgestimate;Levonorgestrel 3-oxime; 17-Deacetylnorgestimate;Norelgestromin (1468454)
- CBNumber:
- CB1500552
- 化学式:
- C21H29NO2
- 分子量:
- 327.46
- MOL File:
- 53016-31-2.mol
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ノルエルゲストロミン 物理性質
- 融点 :
- 107-109°C
- 沸点 :
- 491.9±45.0 °C(Predicted)
- 比重(密度) :
- 1.23±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- Sealed in dry,2-8°C
- 溶解性:
- DMF: 11 mg/ml; DMSO: 10 mg/ml; Ethanol: 12 mg/ml; PBS (pH 7.2): 0.25 mg/ml
- 外見 :
- A solid
- 酸解離定数(Pka):
- 12.22±0.60(Predicted)
- CAS データベース:
- 53016-31-2
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
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| 注意喚起語 |
危険 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H351 |
発がんのおそれの疑い |
発がん性 |
2 |
警告 |
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P201, P202, P281, P308+P313, P405,P501 |
| H360 |
生殖能または胎児への悪影響のおそれ |
生殖毒性 |
1A, 1B |
危険 |
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| 注意書き |
| P201 |
使用前に取扱説明書を入手すること。 |
| P308+P313 |
暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。 |
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ノルエルゲストロミン 価格
もっと(3)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
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富士フイルム和光純薬株式会社(wako)
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W01USP1471958 |
デアセチルノルゲスチメート ((E)- and (Z)-17-deacetyl norgestimate mixture)
Deacetylnorgestimate ((E)- and (Z)-17-deacetyl norgestimate mixture) |
53016-31-2 |
25mg |
￥283900 |
2023-06-01 |
購入 |
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Sigma-Aldrich Japan
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1468454 |
United States Pharmacopeia (USP) Reference Standard
Norelgestromin United States Pharmacopeia (USP) Reference Standard |
53016-31-2 |
200mg |
￥90100 |
2024-03-01 |
購入 |
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Sigma-Aldrich Japan
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1471958 |
United States Pharmacopeia (USP) Reference Standard
Deacetylnorgestimate United States Pharmacopeia (USP) Reference Standard |
53016-31-2 |
25mg |
￥170000 |
2023-06-01 |
購入 |
ノルエルゲストロミン 化学特性,用途語,生産方法
効能
避妊薬
説明
Ortho Evra@ is the first birth control transdermal patch and contains a combination of
norelgestromin and ethinylestradiol. The patch can be applied to the buttocks, lower
abdomen, upper torso or arms; changed weekly for 3 weeks, followed by a patch-free
week. Norelgestromin is the active metabolite produced following oral administration of
norgestimate, the progestin component of the contraceptive, Ortho-Cyclen
?. The half-life
value of norelgestromin was approximately 28 h. Following application, norelgestromin
rapidly appeared in the serum, reached a plateau by approximately 48h and was
maintained at an approximate steady state throughout the wear period. Hepatic
metabolites of norelgestromin included norgestrel and various hydroxylated and conjugated metabolites that were eliminated by renal and fecal pathways. Ortho Evra
produced ovarian suppression and cycle control. It was significantly more effective in
suppressing follicular development than the leading oral contraceptive Triphasil
? (ethinyl
estradiol/levomorgestrel); was as effective in preventing pregnancies and had similar
tolerability profile. The patch offers 99% efficacy when used appropriately, as shown by
three clinical trials. However, a statistically significantly greater proportion of pregnancies
occurred among women weighing 90 kg or more. Ortho Evra
? was well tolerated, with
2.6% of women discontinuing treatment due to mild to moderate reactions at the site of
application. Thus, the patch combined the efficacy of oral contraceptives with the
convenience of just once-weekly dosing.
化学的特性
White Solid
ノルエルゲストロミン 上流と下流の製品情報
原材料
準備製品
ノルエルゲストロミン 生産企業
Global( 56)Suppliers
53016-31-2(ノルエルゲストロミン)キーワード:
- 53016-31-2
- (17α)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one OxiMe
- (17α)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one-d6 OxiMe
- (-)-NorelgestroMin-d6
- (17alpha)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one oxime
- (E)- and (Z)-17-Deacetylnorgestimate mixture
- Norgestimate metabolite Norelgestromin
- 17-Desacetyl Norgestimate ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)
- Deacetylnorgestimate (Mixture of (E)- And (Z)-17-Deacetyl Norgestimate)
- (17R)-13-Ethyl-17-hydroxy-18,19-dinor-pregna-4-ene-20-yne-3-oneoxime
- [17R,(+)]-17-Hydroxy-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one oxime
- [17R,(+)]-17-Hydroxy-13-ethyl-18,19-dinorpregna-4-ene-20-yne-3-oneoxime
- Desacetylnorgestimate
- DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)
- ,10-alpha,13-alpha,14-beta)-
- 18,19-dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-,oxime,(8-alpha,9-beta
- levonorgestreloxime
- 17-Deacetylnorgestimate
- (17a)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one Oxime
- 18-Methylnorethindrone oxime
- BRN 4202099
- D-Norgestrel 3-oxime
- Levonorgestrel 3-oxime
- RWJ 10553
- 13-ETHYL-17_-HYDROXY-18,19-DINORPREGN-4-EN-20-YN-3-ONE OXIME
- 17-Desacetyl Norgestimate Solution, 100ppm
- 17-Desacetyl Norgestimate (Mixture of Isomers)
- 17-Deacylnorgestimate
- 17-Desacetyl Norgestimate-d7 (Mixture ofIsomers) (Norelgestromin-d7)
- 17-Desacetyl Norgestimate (Mixture of Isomers) (Norelgestromin)
- 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, oxime, (17α)-
- [17R,(+)]-17-ヒドロキシ-13-エチル-18,19-ジノルプレグナ-4-エン-20-イン-3-オンオキシム
- ノルエルゲストロミン
- 17-デアセチルノルゲスチマート
- (17R)-13-エチル-17-ヒドロキシ-18,19-ジノル-プレグナ-4-エン-20-イン-3-オンオキシム
- デアセチルノルゲスチメート ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)
- (1R,3aS,3bR,9aR,9bS,11aS)-11a-エチル-1-エチニル-7-(ヒドロキシイミノ)-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-シクロペンタ[a]フェナントレン-1-オール