1,2-ジメトキシエタン 化学特性,用途語,生産方法
外観
無色澄明の液体
溶解性
水に可溶, エタノール, 炭化水素系溶剤に可溶。水、エタノール及びアセトンに極めて溶けやすい。
用途
溶剤、冷凍機冷媒、吸収剤,(酸性)ガス洗浄剤
用途
主に溶剤、加工助剤として産業用化学品の製造配合製剤
用途
汎用溶剤。
説明
1,2-Dimethoxyethane (DME) is a liquid ether used as an aprotic solvent. It is also known as glyme, monoglyme, dimethyl glycol, ethylene glycol, dimethyl ether, dimethyl cellosolve, and DME. It has the special ability to form chelates thanks to the high flexibility of its chains. Moreover, DME is the molecular model system for the poly(oxyethylene) chain. It is commonly used as a solvent in batteries and in organometallic reaction chemistry since it has higher boiling than diethyl ether and THF[1].
化学的特性
Ethylene glycol dimethyl ether, also called 1,2-Dimethoxyethane, is a colorless liquid with a strong smell similar to ether. It is stable and does not easily react. It can dissolve different resins and cellulose, and can be mixed with water and various organic solvents like alcohols, ketones, and esters in any amount. Its solubility can be changed by diluting it with water or specific solvents.
定義
ChEBI: 1,2-dimethoxyethane is a diether that is the 1,2-dimethyl ether of ethane-1,2-diol. It has a role as a non-polar solvent. It is functionally related to an ethylene glycol.
主な応用
Monoglyme serves as an electrolyte solution component for lithium batteries. It is also frequently utilized as a solvent in organometallic reactions, particularly those involving organolithium compounds. Additionally, it can act as a ligand in certain chemical reactions.
一般的な説明
A liquid with a sharp odor. Less dense than water. Flash point 34°F. Mildly toxic by ingestion and inhalation. Severely irritates skin and eyes. Vapors heavier than air. Used to make other chemicals.
空気と水の反応
Highly flammable. Slightly soluble in water.
反応プロフィール
When the solvent, 1,2-Dimethoxyethane, was poured into a funnel previously used to introduce the lithium aluminum hydride, a fire ignited the funnel, [MCA Case History 1182(1966)].
危険性
Moderate fire risk.
健康ハザード
If ingested causes nausea, vomiting, cramps, weakness, coma.
火災危険
Behavior in Fire: Containers may explode in fires.
安全性プロファイル
An experimental
teratogen. Other experimental reproductive
effects. Readdy forms an explosive peroxide.
A very dangerous fire hazard when exposed
to heat, flame, or oxidzers. Mixture with
lithium tetrahydroaluminate may ignite orexplode if heated. When heated to
decomposition it emits acrid smoke and
fumes. See also GLYCOL ETHERS.
合成
1,2-Dimethoxyethane is derived from the reaction of ethylene glycol monomethyl ether with sodium metal and methyl chloride. The ethylene glycol monomethyl ether and the metal sodium were refluxed together until the metal sodium was completely reacted, the temperature was lowered to 45° C., and methyl chloride was introduced. After the reaction is completed, fractional distillation is performed to collect fractions at 84-85.5°C to obtain 1,2-Dimethoxyethane.
純化方法
Traces of water and acidic materials have been removed from it by refluxing with Na, K or CaH2, decanting and distilling from Na, K, CaH2 or LiAlH4. The reaction has been speeded up by using vigorous high-speed stirring with molten potassium. For virtually complete elimination of water, 1,2-dimethoxyethane has been dried with Na-K alloy until a characteristic blue colour is formed in the solvent at Dry-ice/cellosolve temperatures: the solvent is kept with the alloy until distilled for use [Ward J Am Chem Soc 83 1296 1961]. Alternatively, glyme, refluxed with benzophenone and Na-K, is dry enough if, on distillation, it gives a blue colour of the ketyl immediately on addition to benzophenone and sodium [Ayscough & Wilson J Chem Soc 5412 1963]. It has also been purified by distillation under N2 from sodium benzophenone ketyl (see above). [Beilstein 1 IV 2376.]
1,2-ジメトキシエタン 上流と下流の製品情報
原材料
準備製品
テトラヒドロジフェルロイルメタン
2-アミノキノリン
3-アミノビフェニル
2'-デオキシ-5-クロロウリジン
4‐(4‐ホルミル‐1,3‐チアゾール‐2‐イル)テトラヒドロ‐1(2H)‐ピリジンカルボン酸TERT‐ブチル
2-Bromo-5-hydroxypyridine radical ion(1+)
4-ベンジルモルホリン-2-カルボン酸
1-メチルインドール-5-ボロン酸
トリス〔3-(トリフルオロメチルヒドロキシメチレン)-D-カンフォラト〕ユウロピウム(III)
2-Chloro-5-cyano-3-methylpyridine
キナクリドン
4-クロロ-1,3-ジメチル-1H-ピラゾロ[3,4-B]ピリジン-5-カルボン酸
3-N-BOC-アミノアゼチジン
4-クロロ-7-メチルチエノ[3,2-D]ピリミジン
(1R,4R)-1,7,7-トリメチル-3-(トリフルオロアセチル)ビシクロ[2.2.1]ヘプタン-2-オン
1-(2,4-ジフルオロフェニル)-6-フルオロ-1,4-ジヒドロ-7-(3-メチル-1-ピペラジニル)-4-オキソ-3-キノリンカルボン酸
アゼチジン
N,N-DIPHENYLQUINACRIDONE
Pigment Red 122
4-チアゾールカルボン酸
2-クロロ-5-ヨード-3-メチルピリジン
7-Methylthieno[3,2-d]pyrimidin-4(3H)-one
4-メトキシ-3-オキソブタン酸エチル
サラフロキサシン
10-ウンデシン酸
3,4-ジクロロ-N-メチルアニリン
N,N'-ジメチルキナクリドン (D2687の精製品)
THIOPHENE-2,5-DICARBOXYLIC ACID MONOMETHYL ESTER
DCJTB
4-(5-ホルミル-4-メチル-1,3-チアゾール-2-イル)ピペリジン-1-カルボン酸TERT-ブチル
TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISOINDOLINE-2-CARBOXYLATE
ベラプロスト
1,1,1-トリクロロアセトン
2,3,5,6-テトラフルオロベンジル アルコール
2-フェニルマロンアミド
5-ホルミル-2-チオフェンカルボン酸
4'-ブロモ-3'-フルオロアセトアニリド
2,3,5,6-テトラフルオロ-4-メチルベンジルアルコ-ル