ANGIOTENSIN II, HUMAN

ANGIOTENSIN II, HUMAN 구조식 이미지
카스 번호:
4474-91-3
상품명:
ANGIOTENSIN II, HUMAN
동의어(영문):
ANGIOTENSIN II;Ang II;DRVYIHPF;TY-10721;AngiotensinⅡ;ANGIOTENSIN-2;H-DRVYIHPF-OH;angiotensin renin;ANTI-ANGIOTENSIN II;ile(5)-angiotensini
CBNumber:
CB0338057
분자식:
C50H71N13O12
포뮬러 무게:
1046.2
MOL 파일:
4474-91-3.mol

ANGIOTENSIN II, HUMAN 속성

끓는 점
809.08°C (rough estimate)
밀도
1.1257 (rough estimate)
굴절률
1.6700 (estimate)
RTECS 번호
BW2165000
저장 조건
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
용해도
insoluble in DMSO; insoluble in EtOH; ≥100.2 mg/mL in H2O
물리적 상태
가루
산도 계수 (pKa)
pK1: 10.37 (25°C)
색상
오렌지 레드
색상
오렌지색
수용성
물(25mg/ml) 및 5% 아세트산(1mg/ml)에 용해됩니다.
시퀀스
H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
안정성
흡습성
InChIKey
CZGUSIXMZVURDU-JZXHSEFVSA-N

안전

WGK 독일 3

ANGIOTENSIN II, HUMAN C화학적 특성, 용도, 생산

개요

It is known that tumor tissues including metastatic lymph nodes are composed of newly growing vessels which lack blood flow autoregulation and are influenced only secondarily by the responding somatic vessels. Human angiotensin II (AT II). a vasopressor, was introduced in Japan to improve the efficacy of systemic chemotherapy. In patients with various advanced cancers, i.v. infusion of AT II to achieve a mean blood pressure of 1.5 times of baseline (but not over 150 mm Hg) followed by a bolus injection of conventional cytotoxic agents increases blood flow 5-7 fold in tumor tissues and therefore, increases drug delivery to the target tissue resulting in enhanced chemotherapeutic effects. This induced-hypertension chemotherapy regimen can be performed safely with minimal side effects.

용도

Cardiopulmonary resuscitation - not yet an approved application

일반 설명

Functions in blood pressure maintenance. Stimulates the release of aldosterone from the adrenal gland. Has strong vasoconstrictive effects. Increases the entry of Ca2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Activates JAK2 in smooth muscle cells. Activates p125FAK and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates pp60c-src in vascular smooth muscle cells. Inhibits adenylate cyclase activity in spontaneously hypertensive rats.

ANGIOTENSIN II, HUMAN 준비 용품 및 원자재

원자재

준비 용품


ANGIOTENSIN II, HUMAN 공급 업체

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